Los Alamos National Laboratory, Mail Stop K480, P.O. Box 1663, Los Alamos, NM 87545

A -- EXTENDING THE USEFUL STORAGE LIFE OF REFRIGERATED BLOOD: A RATIONAL APPROACH Sol IPO-95-443. Contact Mark W. Bitensky, Biophysics Group, MS K480, Los Alamos, NM 87545, Tel: (505) 667-9420, FAX: (505) 665-1464. The University of California which operates Los Alamos National Laboratory (LANL) under contract to the Department of Energy (DOE), is seeking an industrial partner(s) in the field of blood storage and transfusion medicine. Ongoing research activity at LANL has resulted in more complete understanding of the damage pathways that operate during refrigerated storage of human red blood cells at 4 degrees centigrade. This has permitted the identification of effective countermeasures for each damage pathway and has further resulted in the demonstration of significant prolongation of the useful shelf life of refrigerated red cells as a consequence of the synergistic deployment of these countermeasures. These developments have profound implications for improving the logistics of blood banking as well as the practicability of autologous (patient to self) transfusion. Patent disclosures for these discoveries have been submitted. Any company that wishes to receive more information concerning this program must respond with a statement of intent, describing the company's technical expertise, production and marketing capabilities, financial resources, previous technology transfer experience, and motivation for participation in this program. This statement must be dated within 1.5 business days from the date of this notice. (192)

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