National Institute of Child Health and Human Development, Contracts Management Branch, Executive Building, Rm. 7A07, 6100 Executive Blvd. MSC 7510, Bethesda, Maryland 20892

A -- EVALUATION EFFECTIVENESS OF INTRAPARTUM ANTIBIOTIC AND PROPHYLAXIS AGAINST EARLY-ONSET GROUP B STREPTOCOCCAL (GBS) DISEASE Sol NICHD-DESPR-SS-00. Contact Mrs. Lynn Salo, 301-496-4611/Contract Specialist, Harvey Shifrin, 301-496-4611/Contracting Officer. A study sponsored by the National Institute of Child Health and Human Development is planned to evaluate the effectiveness of intrapartum antbiotic prophylaxis given to high risk women (selective antibiotic prophylaxis) with the intent to prevent early-onset neonatal group B streptococcal (GBS) disease. Selective antibiotic prophylaxis fails to prevent 25% - 30% of cases of early-onset neonatal GBS disease. This is being designed as a retrospective case-control analysis to measure effectiveness of selective antibiotic prophylaxis. The results of this analysis may provide additional evidence supporting the need for new approaches for the prevention of neonatal GBS disease such as, active immunization of women before or during pregnancy. The study data currently being gathered by the seven sites on the prevelance of GBS will be used to perform the proposed retrospective study. These study sites include: Children's Hospital Medical Center of Northern California, Magee-Womens Hospital, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School, University of Florida, Gainesville, University of Alabama at Birmingham, Columbia University and Baylor College of Medicine. We are planning to perform and award this project to the above mentioned organizations. THe purpose of this synopsis is to determine whether there are other sources with the requisite qualifications to perform the work described above. Capability statements should be submited with 45 days of the publication of this synopsis to: Mr. Harvey Shifrin, Contracting Officer, Contracts Management Branch, Executive Building, Rm. 7A07, 6100 Executive Blvd. MSC 7510, Bethesda, Maryland 20892. See Numbered Note 22. (184)

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