National Institute of Environmental Health Sciences, Contracts and Procurement Management Branch, OM, 79 T.W. Alexander Drive, Building 4401, Research Commons, Research Triangle Park, NC 27709

A -- IDENTIFICATION OF CHROMOSOMAL BAND REGIONS IMPLICATED IN CLINICAL OUTCOMES IN BREAST, MELANOMA AND OVARIAN CANCERS POC Contact Phillip D. Jones, Contracting Officer, 919/541-0426 The National Center for Human Genome Research intends to negotiate with theUniversity of Arizona for an approximate two year period project. Evidence continues toaccumulate that specific chromosomal abnormalities may be associated with poor clinicaloutcomes, particularly in hematologic tumors. The purpose of the project is to extend this lineof investigation to the significantly more common and lethal solid tumors, including ovariancarcinoma, melanoma, and breast carcinoma. The investigation of these three distinct tumortypes will allow a determination of cytogenetic changes important in the biology of the diseaseprocess. The database of cytogenetic and clinical data collected at the Arizona GeneticOncology Program is unique in the world and is the largest of its kind. Its size together withthe careful clinical and pathological characterization provides the only opportunity todistinguish the non-random occurrence of cytogenetic abnormalities from a large subset ofpatients with ovarian, breast cancer and melanoma. Authority: 41 USC 253(c)(1), as set forthin FAR 6.302-1. Restricted access to the data, inherent duplication of cost to the Governmentand unacceptable delays in completing the project make competition unfeasible. SeeNumbered Note 22. (0171)

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