Contract Management Branch, NIH, NIAID Solar Building, Room 3C07, 6003 Executive Blvd. MSC 7610 Bethesda, MD 20892-7610

A -- CLINICAL STUDIES OF THERAPIES FOR VIRUS INFECTIONS SOL NIH-NIAID-DMID-96-10 DUE 062595 POC Frank Murphy, Contract Specialist, fm13k@nih.gov, (301) 496-2509. The Virology Branch, Division of Microbiology and Infectious Diseases Program of the National Institute of Allergy and Infectious Diseases is seeking a multicenter collaborative group to continue ongoing clinical trials and conduct new trials to evaluate new therapies for severe virus infections (including: herpes simplex encephalitis, neonatal herpes, varicella zoster virus infections, cytomegalovirus infections, parainfluenza virus infections, respiratory syncytial virus infections, and Epstein Barr virus-mediated diseases). This solicitation does not include studies of therapies for Human Immunodeficiency Virus (HIV), but does include therapies for the above stated virus infections in HIV-infected and other immunocompromised subjects. The NIAID solicits proposals from medical institutions qualified to serve as the sole Contracting Unit or as the Central Unit of a collaborative trial. The Contractor must have demonstrated experience in the clinical evaluation of antivirals and the demonstrated capacity to organize and administer a collaborative clinical study. This announcement is a new solicitation. The issuance of the RFP will be on June 19, 1995 and proposals will be due at COB on September 15, 1995. It is anticipated that one contract may be awarded as a result of this solicitation. It is expected that the contract will have a seven-year period of performance. RFP-NIH-NIAID-DMID-96-10 will be available electronically through the NIH Gopher and via modem using the following electronic mail addresses and instructions: 1) To access the NIH Gopher: Point your gopher client to GOPHER.NIH.GOV PORT 70 (you should now be in the NIH Gopher). Select ''Grant and Research Information'', then select ''R&D Request for Proposals (RFP)''. 2) To access the NIH Grant Line via modem: Configure your terminal emulator as: 1200 or 2400 baud, even parity, 7 data bits, 1 stop bit, Half Duplex. Using the procedure specified in your communication software, dial 301-402-2221. When you get a response indicating that you have been connected, then type,GEN1 (the comma is mandatory) and press ENTER; you will be prompted by the NIH system for ''INITIALS?''. Type BB5 and press ENTER. You will then be prompted for ''ACCOUNT?''. Type CCS2 and press ENTER. Read the 12/22/94 News Flash for additional instructions. Please note that the RFP for this procurement has been revised to include only the Work Statement, deliverable and reporting requirements, special requirements and mandatory qualifications, if any, the Technical Evaluation Criteria, and proposal preparation instructions. All information required for the submission of an offer will be contained in the revised RFP package. Following proposal submission and the initial review process, offerors comprising the competitive range will be requested to provide additional documentation (e.g., Representations and Certifications) to the Contracting Officer. This advertisement does not commit the Government to award a contract. (0153)

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