National Institutes of Health, National Institue of Allergy and Infectious Diseases, Contract Management Branch, Solar Building, Room 3C07, 6003 Executive Blvd. MSC 7610, Rockville, MD 20892-7610

A -- SAFETY EVALUATION FOR ANTI-INFECTIVE THERAPIES SOL NIAID-DAIDS-96-16 DUE 081195 POC Bruce E. Anderson, Contracting Officer, (301)496-8371. The Drug Development and Clinical Sciences Branch, Treatment Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, is soliciting proposals from laboratories with experience in conducting preclinical animal toxicology and pharmacokinetic evaluations, in compliance with FDA Good Laboratory Practices guidelines. Some evaluations in non-human primates will be required. Standard Operating Procedures to be followed in conducting these studies will be included with the solicitation. This work will directly support selected DAIDS-supported clinical and preclinical investigations on potential therapies for HIV infection and for infection with opportunistic pathogens that affect AIDS patients. The agents to be tested will be experimental synthetic organic chemicals and products of biotechnology. It is anticipated that one (1) cost-reimbursement, completion-type contract wil be awarded for a period of five (5) years. The electronic version of RFP-NIH-NIAID-DAIDS-96-16 will be available on or about May 12, 1995, through the NIH Gopher and Internet using the following electronic mail addresses and instructions: 1) To access the NIH Gopher: Point your gopher client to GOPHER@NIH.GOVPORT 70 (you should now be in the NIH Gopher). Select ''Grant and Research Information'', then select ''R&D Request for Proposals (RFP)''. 2) To access the NIH Grant Line (Internet): Configure your terminal emulator as: 1200 or 2400 baud, even parity, 7 data bits, 1 stop bit, Half Duplex. Using the procedure specified in your communication software, dial 301-402-2221. When you get a response indicating that you have been connected, then type,GEN1 (the comma is mandatory) and press ENTER; you will be prompted by the NIH system for ''INITIALS?''. Type BB5 and press ENTER. You will then be prompted for ''Account?''. Type CCS2 and press ENTER. Please note that the RFP for this procurement has been revised to include only the Statement of Work, deliverable and reporting requirements, Mandatory Qualification Criterion, the Technical Evaluation Criteria, and proposal preparation instructions. All information required for the submission of an offer will be contained in the electronic RFP package. Following proposal submission and the initial review process, offerors comprising the competitive range will be requested to provide additional documentation to the Contracting Officer. Responses to this RFP will be due on or about August 11, 1995. Any responsible offeror may submit a proposal which will be considered by the Government. This advertisement does not commit the Government to award a contract. Point of Contact: Bruce E. Anderson; Contracting Officer; Electronic mail address: ba9i@nih.gov; Telephone: (301) 496-8371; Fax: (301) 402-0972 (0109)

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