National Institutes of health, Division of Procurement, AB-B 6120 Executive Blvd., Room 828, Rockville, MD 20892

66 -- FURNISH AND INSTALL A BIACORE 2000 SOL 263-95-P(BD)-0123 DUE 051995 POC Marcia Goldman, Contracting Officer, (301) 496-2302. 17. The National Institues of Health (NIH) has a requirement to purchase a BIAcore 2000 to be delivered F.O.B. destination to Bethesda, Maryland. The BIAcore 2000 is required by the National Institutes of Allergy and Infectious Diseases (NIAID) which offers the opportunity to study binding interactions between biomolecules in real time, thereby allowing kinetic analysis not possible by other technologies. Moreover, the technology cirumvents the need to label the molecular spieces of interest, thereby avoiding potential false results associated with modifications caused by labeling, as well as the time, expense biohazards, and disposal costs associated with modifications caused by labeling process(i.e., when radioisotopes are used). NIH intends to contract with Pharmacia Biosensor, 800 Central Avenue, P.O. Box 1327, Piscataway, N.J. 08855 under the authority of FAR 6.302-1 for this equipment. It is believed that Pharmacia Biosensor is the sole source with the required specifications needed. The equipment necessary for use by the NIAID must have the following specifications: 1. Instrument shall use surface plasmon resonance to detect and continuously monitor molecular interactions simutaneously in up to 4 flow cells in real-time, label free. 2. Instrument shall be fully automated for sample handling and shall include sample recovery and fraction collection. 3. Instrument shall be capable of detecting low molecular weight molecules in a wide range of temperatures. 4. Contractor shall allow for trade- in of Government owned BIAcore s/n 33-5350-0415 purchased in September 1994. This is not a formal solicitation. Concerns that respond to this notice must furnish concise responses directed specifically to the requirements mentioned above. Sources demonstating the capability to accomplish the above shall supply pertinent information in sufficient detail to demonstrate that ability to perform. Infromation furnished shall include enough material to perform a proper evaluation by. Interested parties may submit detailed data by which to evaluate capabilities to the attention of Marcia Goldman at the address above. This notice may represent the only official notice of such procurement. See note(s) 12, 22 (0050). (0093)

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