National Cancer Institute, Research Contracts Branch, Purchasing and Support Contracts Section, EPS/638, 6120 EXECUTIVE BLVD MSC 7228

65 -- CACHE WORKSTATION SOL N02-CM-56235-84 POC Eileen Keating, Contract Specialist or Janet Mattson, Contracting Officer, 301/402-4509. The National Cancer Institute, Laboratory of Medicinal Chemistry (LMC) plans to procure on a SOLE SOURCE basis under authority of FAR 6.320-1, in accordance with 41 U.S.C. 253(c)(1), a Cache Workstation and related components from Cache Scientific. It is essential that the LMC purchase a Cache Workstation in order to meet their molecular modeling needs for several research projects. In order to meet the needs of their research projects, the system must have the following specifications: The product must be 100% compatible (fully icon and menu driven) with Macintosh computers. It must have the capability to graphically build any molecule composed of any element up to Lawrencium (element 103). It must allow the stereoscopic display of structures, optimization pathways, partial charges, bond orders, molecular orbitals, gradient mapped electron densities, electrostatic isopotentials, super delocalizabilities, and visualization with analysis of compound's UV spectra interactively coupled to a molecular display window which reveals chromophores upon selection of spectral peaks and visualization of corresponding molecular orbitals. It must provide full support for viewing and pointing three dimensional objects with a pointing device (i.e. mouse) and a holding device (i.e., a 3-D trackball). It must allow the user to construct three- dimensional structures using a viewable tethered three dimensional cursor. Since the work intended requires intensive use of three dimensional displays of asymmetric molecules this capability is indispensable. It must allow the user to edit or visualize several molecules in separate, concurrent stereoscopic or mono windows. Furthermore, it must allow the user to manipulate selected portions, as well as all of a molecule and to paste it or copy it into another window. It must be able to transfer images directly from the molecular visualization applications into a standard word processing, drawing and paint program at specified resolution up to 300 dpi. It is the Government's belief that the above specifications can only be met by Cache Scientific. This notice of intent is not a request for competitive proposals, however, if an interested party believes they can meet the above specifications, they may submit a statement of capabilities. Information furnished shall include enough material, in sufficient detail to perform a proper evaluation of their ability to perform. Closing date is 45 days after publication of this notice. SEE Note 22. (0075)

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