National Heart, Lung, & Blood Institute, Contracts Operations Branch, Procurement Section, Westwood Building, Room 836, 5333 Westbard Avenue, Bethesda, MD 20892

66 -- NANO-DIFFERENTIAL SCANNING CALORIMETER SOL NHLBI-HL-P-95-103 POC Kathleen J. Van Steelant, Contract Specialist, (301) 594-7874 Gina M. Cianflone, Procurement Assistant, (301) 594-7874. It is the intent of the National Heart, Lung, and Blood Institute (NHLBI) to negotiate on a sole source basis under the authority of 41 USC 253 (c)(1) and FAR 6.302-1 with Calorimetry Sciences Corporation to purchase a Nano-Differential Scanning Calorimeter System (Nano-DSC-C/3ATM-94A) for installation in the Section on Protein Chemistry, Laboratory of Biochemistry, NHLBI, Bethesda, Maryland 20892. The system will allow accurate studies of thermally induced unfolding reactions as well as the characterization of solution conformation and solvation of oligomeric proteins at micromolar concentrations. The instrument must meet the following minimum specifications: 1) the nano differential scanning calorimeter will be capable of measuring absolute heat capacity, 2) solid state (no water cooling) requirement for means of heating and cooling, 3) capillary cell construction (0.9 ml volume capacity) with cells made of 24-K gold with 99.99% platinum inlet tubing, 4) both up-scan and down-scan capability, 5) pressurization up to 3 atmospheres, 6) direct reading of block temperature and cell temperature, 7) Resolution of scans = 16 bits (65536 steps), 8) rapid response with a half-time of ~ 5 seconds, sensitivity at the 2 fcal/deg level, and base line repeatability of 10 fcal/deg at 1 C/min, 9) operating temperature range of 0 to + 125 xC with scan rates up to 2x/min in both heating and cooling directions. Interested parties may identify their interest and capability to respond to the requirement or submit proposals. This notice of intent is not a request for competitive proposals. However, all proposals received within the forty-five days after the date of publication of this synopsis will be considered by the Government. A determination by the Government not to open the requirement to competition based upon responses received as a result of this notice of intent will normally be considered solely for the purpose of determining whether to conduct a competitive procurement. Oral communications are not acceptable and cannot be honored. Interested parties may express their concerns in writing. Written responses must contain clear and convincing documentation, technical information and descriptions demonstrating the ability to meet the stated requirement. All responses must be received within 45 calendar days from the publication date of this notice and should be directed to Kathleen J. Van Steelant or Gina M. Cianflone at the above address. Responses received by facsimile will not be honored. See Number Note 22. (0060)

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