Contract Management Section, National Institute of Dental Research, NIH, Natcher building, Room 4AN-44D, Bethesda, Maryland 20892-6402

A -- PASSIVE IMMUNIZATION: TREATMENT OF RABIES VIRUS INFECTION WITH HUMAN MONOCLONAL ANTIBODIES SOL RFP NO. NIH-NIDR-2-95-6R. DUE 033095. POC Marion Blevins, 301/594-0652. The National Institute of Dental Research has a requirement for the generation of rabies virus neutralizing human monoclonal antibody (mAbs), preferenctially of the high affinity IgG isotype, so that a "cocktail" of several neutralizing human mAbs can be prepared against multiple antigenic sites on the viral glycoprotein (GP) and ribonucleoprotein (RNP) complex. The specific objectives of the project are: (1) to generate at least 15 high affinity virus-neutralizing human IgG mAbs against various antigenic determinants on rabies virus using human hybridoma technology, and (2) to show that these mAbs protect animals against lethal rabies challenge. Offerors must have access to blood from healthy donors immunized with rabies vaccine and must demonstrate prvious successful establishment of mAbs. This is an announcement for an anticipated Request for Proposal (RFP). RFP No. NIH-NIDR-2-95-6R will be available approximately February 17, 1995, with a closing date tentatively set for March 30, 1995. (026)

Loren Data Corp. http://www.ld.com (SYN# 0011 19950131\A-0011.SOL)