Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545

A -- BASIC RESEARCH WORK Sol IPO-95-019. Contact Charles Rzeszutko, Industrial Partnership Office, MS K571. (505) 665-3613, FAX (505) 665-0154. The University of California, which operates the Los Alamos National Laboratory (LANL) under contract to the Department of Energy, is a major partner in the National Laboratory Gene Library Project. The goal of this project was to produce chrmosome-specific cosmid libraries and to distribute the clones to the scientific community worldwide. In these chromosome-specific libraries, the cloned fragments that make up each ``library'' are derived from one of the 24 human chromosomal types, after purification by flow sorting. The cosmid libraries have been arrayed to a depth of at least five-fold as individual clones in 96-well microtiter dishes, each clone having a unique identifier. The arrayed cosmid libraries for human chromosomes 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 20, X, and Y (``Libraries'') are available from LANL. We are looking for companies (``Recipients'') who wish to act, on a non-exclusive basis, as resource/distribution centers for screening these arrayed Libraries and for distributing individual clones from the Library to ``End Users.'' End Users of the clones should be encouraged to make data on the use of clones available to the scientific community by publication and submission of data to appropriate databases. Recipients of the LANL arrayed cosmid Libraries may not rearray the Libraries so as to create new clone identifiers, and may not transfer the Libraries to any third party without prior written consent by an authorized representative of LANL. The arrayed Libraries will be transferred from LANL via an Agreement between the Recipient and The Regents of the University of California. The Recipient will be asked to offset the costs of the array replication and transfer (approx. $1,000 - $5,000 per array replica). The Agreement will be coordinated through the LANL Industrial Partnership Office (IPO). Recipients should note that no license, either direct or implied, would be granted via this Agreement to any other University-owned intellectual property. LANL on behalf of the Federal Government will retain rights to continue research pertinent to the Libraries on behalf of the United States throughout the world. The Regents of the University of California also expressly reserves the right to continue the distribution and use of the Libraries for educational and research purposes. If you are interested in obtaining the arrayed LANL cosmid Libraries, please respond in writing, either by letter or e-mail, to LANL providing the following information: (1) The name and address of your organization; (2) the name, address, telephone and facsimile number of the point of contact in your organization for this agreement; (3) the expertise and facilities that your organization possesses that would qualify you as a distribution/screening center; and (4) the time frame in which you are willing to accept these Libraries. Please send this information to Los Alamos National Laboratory, Industrial Partnership Office, Mail Stop K571, Los Alamos, NM 87545, Attn: Chuck Rzeszutko or via e-mail to cpr@lanl.gov. For further information, please call Chuck Rzeszutko at (505) 665-3613 or e-mail your inquiries to cpr@lanl.gov. (020)

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