National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Natcher Building, Room 5AS-13A, 45 Center Drive, MSC 6500, Bethesda, MD 20892-6500

A -- LUPUS MULTIPLEX REGISTRY AND REPOSITORY SOL RFP-NHIH-NIAMS-95-1. Contact Point, Diana Lynn Wheeler, Contract Specialist, 301/594-2543. The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) intends to negotiate with the Oklahoma Medical Research Foundation, Oklahoma City, Oklahome, for a five and one-half year period to further collect and characterize multiplex lupus pedigrees and to establish a core facility, which will serve as a registry of lupus pedigrees. The facility will also operate as a repository of sera, cells and DNA and will conduct the genotyping of the pedigrees enrolled. A determination of use other than full and open competition has been made in accordance with 41 U.S.C. 253(c)(1) as set forth in FAR 6.302-1. The Contractor is determined to be the only responsible source, based on its unique capabilities relative to the recruitment and genotyping of families, including African Americans, with multiple cases of lupus. A system of pedigree accrual is presently in place at the Foundation and to date, they have collected 35 African American and 37 European American Pedigrees. In addition, full characterization and genotyping has been accomplished in about half of the pedigrees enrolled. This is not an announcement of the availability of a Request for Proposal. See Note 22. (020)

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