SOURCES SOUGHT
66 -- Deep Proteomic Profiling of NIA Samples with the Proteograph Proteomics Platform (Brand name or Equal)
- Notice Date
- 5/4/2024 3:05:55 PM
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- 75N95024Q00275
- Response Due
- 5/20/2024 7:00:00 AM
- Archive Date
- 06/04/2024
- Point of Contact
- Fred Ettehadieh
- E-Mail Address
-
Fred.Ettehadieh@nih.gov
(Fred.Ettehadieh@nih.gov)
- Description
- This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition.� It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract.� Responses will not be considered as proposals or quotes.� No award will be made as a result of this notice.� The Government will NOT be responsible for any costs incurred by the respondents to this notice.� This notice is strictly for research and information purposes only. Background and Objectives: The National Institute on Aging is in need of an automated, comprehensive, unbiased, and quantitative proteomics platform for the discovery proteomic biomarkers in biofluids acquired from multiple research laboratories. The SEER Proteograph Suite is designed to overcome the immense dynamic range problem of biofluids such as serum and plasma, which spans over 10 orders of magnitude and masks the ability of mass spectrometry-based technologies to detect low-abundance proteins, including the vast majority of proteins leaked from tissues, which are the most promising source of biomarkers of blood biomarkers.� Secondly, the Seer Proteograph Analysis Software (PAS), included in the suite, tackles the issue of the scalability of large-scale proteomic studies, which are limited by the immense computational power required for analysis of large omic datasets. The PAS software enables determination of significant biomarkers, pathway analysis, visualizations, and other features for hundreds of proteomic datafiles within a matter of hours within the cloud. Salient Characteristics: � Two-nanoparticle panel. Automation instrument. Software to perform unbiased, deep proteomic analysis at scale in a matter of hours.� Ability to provide the combination of unbiased, deep, rapid, and large-scale access to the proteome. Ability to provide insight into protein variation at the peptide level and protein-to-protein interactions at depth and scale for unbiased and deep proteomics which is otherwise unattainable with existing approaches. Designed to enable broad adoption across a wide variety of customers in both decentralized and centralized settings. Identify and distinguish protein variants at the peptide level. Identify and quantify post-translational modifications and protein-to-protein interactions. Be compatible across a wide range of laboratory workflows, sample processing and detection methods. Anticipated delivery date: 15 weeks days after receipt of order. Capability statement /information sought: Small business concerns that believe they possess the capabilities to provide the required services should submit documentation of their ability to meet each of the project requirements to the Contracting Officer. The capability statement must specifically address each of the project requirements separately.� Additionally, the capability statement should include 1) the total number of employees, 2) the professional qualifications of personnel as it relates to the requirements outlined, 3) any contractor GSA Schedule contracts by which all of the requirements may be met, if applicable, and 4) any other information considered relevant to this program. Small businesses must also provide their Company Name, DUNS number, Physical Address, and Point of Contact Information. Interested small businesses are required to identify their type of business, applicable North American Industry Classification System Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, reference the solicitation notice number. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2� x 11� paper size, with 1� top, bottom, left and right margins, and with single or double spacing. The information submitted must be in an outline format that addresses each of the elements of the project requirements and in the capability statement /information sought paragraphs stated herein.� A cover page and an executive summary may be included but is not required. The response is limited to ten (10) pages.� The 10-page limit does not include the cover page, executive summary, or references, if requested. All capability statements sent in response to this Small Business Sources Sought Notice must be submitted to Fred Ettehadieh, Contracting Officer, by email at fred.ettehadieh@nih.gov before the closing date and time of this announcement. All responses must be received by the specified due date and time in order to be considered. Facsimile responses are not acceptable. �Disclaimer and Important Notes:� This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization�s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in SAM.gov. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).�
- Web Link
-
SAM.gov Permalink
(https://sam.gov/opp/3de8e5f4c8494244af8351a19aa43aff/view)
- Place of Performance
- Address: MD, USA
- Country: USA
- Country: USA
- Record
- SN07053304-F 20240506/240504230049 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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