SPECIAL NOTICE
99 -- Epigenetic Age Analysis/DNA Methylation Testing
- Notice Date
- 7/27/2023 6:57:13 AM
- Notice Type
- Special Notice
- NAICS
- 541715
— Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Contracting Office
- DEPT OF COMMERCE NOAA KANSAS CITY MO 64106 USA
- ZIP Code
- 64106
- Solicitation Number
- 1333MF23Q02778
- Response Due
- 8/11/2023 8:00:00 AM
- Archive Date
- 08/26/2023
- Point of Contact
- Natasha Thieman, Phone: 3014278469
- E-Mail Address
-
natasha.thieman@noaa.gov
(natasha.thieman@noaa.gov)
- Description
- Notice of Intent to Award a Sole-Source Contract Announcement Number: 1333MF23Q02778 The US Department of Commerce (DOC), National Oceanic and Atmospheric Administration (NOAA), National Marine Fisheries Service (NMFS), Office of Protected Resources (OPR), intends to negotiate on a sole source basis, under the statutory authority of FAR 13.106-1(b)(1)(i), with Epigenetic Clock Development Foundation, Torrance, California, for Epigenetic Age Analysis/DNA Methylation Testing services. The North American Industry Classification Code (NAICS) for this acquisition is 541715, Research and Development in the Physical, Engineering, and Life Sciences, with a business size standard of 1,000 employees. Background The methylation analysis approaches described here are fully operational in laboratories and the work will be overseen and managed by the Epigenetic Clock Development Foundation. Each laboratory that performs raw methylation analysis has dedicated infrastructure in place to facilitate quantitative high-throughput and genome-wide measurements of epigenetic marks. The analysis will focus primarily on interrogating DNA methylation in the context of CpG dinucleotides as a key epigenetic mechanism mediating between environment and genome, as it currently represents the most accessible and reliable mark for quantitative epigenetic measurements. DNA methylation studies take advantage of bisulfite treatment of genomic DNA that selectively deaminates cytosine residues that are not methylated, while leaving methylated cytosines intact. Thus, this approach converts epigenetic information to sequence-based information that will be measured in an unbiased genome-wide assay. This project will use the Illumina Horvath Mammalian Methylation Chip. This enables the quantitative interrogation of more than 37,000 CpG methylation conserved mammalian loci per sample. Many researchers study animals that are not widely used, e.g. dogs, cats, dolphins, whales, cattle, swine, elephants, bats. It is not cost effective to develop a DNA methylation array for species that are rarely analyzed. The technology allows one to evaluate whether an intervention that affects DNA methylation levels in one species (e.g. mouse) also affects the corresponding DNA methylation levels in another species (e.g. human), and it is tailor-made for cross-species comparisons. Sole Source Justification The Epigenetic Clock Development Foundation is the only known provider of the technology using the Illumina Horvath Mammalian Methylation Chip with dedicated infrastructure in place to facilitate quantitative high-throughput and genome-wide measurements of epigenetic markers based on raw methylation analysis. The Clock Foundation has the technical analytical expertise to focus primarily on interrogating DNA methylation in the context of CpG dinucleotides as a key epigenetic mechanism mediating between environment and genome, as it currently represents the most accessible and reliable mark for quantitative epigenetic measurements. DNA methylation studies take advantage of bisulfite treatment of genomic DNA that selectively deaminates cytosine residues that are not methylated, while leaving methylated cytosines intact. Thus, this approach converts epigenetic information to sequence-based information that will be measured in an unbiased genome-wide assay. The Illumina Horvath Mammalian Methylation Chip enables the quantitative interrogation of more than 37,000 CpG methylation conserved mammalian loci per sample. Many researchers study animals that are not widely used, e.g. dogs, cats, dolphins, whales, cattle, swine, elephants, bats. The technology allows one to evaluate whether an intervention that affects DNA methylation levels in one species (e.g. mouse) also affects the corresponding DNA methylation levels in another species (e.g. human), and it is tailor-made for cross-species comparisons. While there are contractor that provide targeted analyses to evaluate methylation sites, only Epigenetic Clock Development Foundation has the ability to provide the technology of the broad analyses using the Illumina Horvath Mammalian Methylation Chip and the level of technical detail and expertise needed for interpreting the data. Special Notice This special notice is not a solicitation for competitive quotes, nor will one be posted on Contract Opportunities.� However, if an interested party believes that it is capable of meeting the requirements and be in compliance with the above justification, they may submit substantiating documentation in writing within the open period of this notice.� Responses can be sent via e-mail to natasha.thieman@noaa.gov.� Documentation will be evaluated solely for the purpose of determining whether or not to conduct this procurement on a competitive basis. A determination by the Government not to conduct a competitive procurement, based upon response to this notice, is solely within the discretion of the Government. Oral communications are not acceptable in response to this notice. All responsible sources may submit a Capability Statement in accordance with the solicitation, which shall be considered by the agency if received on or before 11:00 AM EDT on August 11, 2023.� The Capability Statement must contain material in sufficient detail to allow NOAA to determine if the party can meet all of the requirements.� All electronic correspondence shall have the subject line read:� Announcement Number: 1333MF23Q02778 Project Title: Epigenetic Age Analysis/DNA Methylation Testing It is the Offeror�s responsibility to ensure that any submission transmitted to the specified Government representative(s) is received prior to the due date specified herein.� Offerors are highly encouraged to contact the Government representative(s) specified above prior to the solicitation�s stated time and date for receipt of offers to ensure the Government has received the submission.� Offers received after the date and time specified in this solicitation may be excluded from consideration.��� DOC/NOAA/NMFS/OPR requires that all contractors doing business with this office be registered with the System for Award Management (SAM). No award can be made to a company not registered in SAM. For additional information and to register in SAM, please access the following web site: www.sam.gov. To register, all contractors must have a Unique Entity ID (UEI). A UEI may be acquired free of charge by registering at http:// https://sam.gov/content/entity-registration. The notice will remain open from 07/27/2023 to 08/11/2023.
- Web Link
-
SAM.gov Permalink
(https://sam.gov/opp/768d67d4090a40dc9c3e12e66984e04b/view)
- Place of Performance
- Address: USA
- Country: USA
- Country: USA
- Record
- SN06766030-F 20230729/230727230043 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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