SPECIAL NOTICE
Q -- Custom Synthesis of 26 Antisense Oligonucleotides (ASOs) for Liver Tox study
- Notice Date
- 6/13/2023 9:01:41 AM
- Notice Type
- Special Notice
- NAICS
- 541380
— Testing Laboratories
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
- ZIP Code
- 20892
- Response Due
- 6/23/2023 9:00:00 AM
- Archive Date
- 07/08/2023
- Point of Contact
- Kaitlyn Landi, Phone: 3018271804, KJ Shaikh, Phone: 3014436677
- E-Mail Address
-
kaitlyn.landi@nih.gov, kj.shaikh@nih.gov
(kaitlyn.landi@nih.gov, kj.shaikh@nih.gov)
- Description
- INTRODUCTION THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A CONTRACT WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). The National Institute on Drug Abuse (NIDA), Office of Acquisition (OA) the National Center for Advancing Translational Sciences (NCATS), intends to negotiate and award a purchase order without providing for full and open competition (including brand-name) to IDTDNA, Integrated DNA Technologies, Inc. 1710 Commercial Park, Coralville, Iowa 52241, USA for Custom Synthesis of 26 Antisense Oligonucleotides (ASOs) for Liver Tox study. NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE and SET ASIDE STATUS The intended procurement is classified under NAICS 541380 Testing Laboratories and Services with a Size Standard of $16.50. � REGULATORY AUTHORITY This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13�Simplified Acquisition Procedures. Contracts awarded using FAR Part 13�Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6�Competition Requirements. FAR Subpart 13.106-1 (b) Soliciting from a single source provides that: For purchases not exceeding the simplified acquisition threshold, Contracting officers may solicit from one source IF the contracting officer determines that the circumstances of the contract action deem only one source reasonably available (e.g., urgency, exclusive licensing agreements, brand-name OR industrial mobilization). The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2022-08 dated October 22, 2022. DESCRIPTION OF REQUIREMENT PURPOSE AND OBJECTIVES: This requisition establishes a contract to manufacture 26 antisense oligonucleotides (ASOs) commercially. These ASOs are the necessary starting material to be used to evaluate if a platform based on liver spheroid cell cultures can be used for the rapid and reliable prediction of hepatotoxicity associated with administering ASOs. The antisense oligonucleotides will be used for research and require high sequence specificity and purity. Purchase Description: IDT DNA will synthesize and deliver 26 antisense oligonucleotides targeting the human genome. The antisense oligonucleotides will be customized, synthesized, standard desalt purified, and diluted to the required quantity and concentration. NCATS will supply the specific sequence and chemical modifications of the 26 ASOs to be synthesized by IDT. IDT DNA will synthesize and deliver 26 antisense oligonucleotides. The antisense oligonucleotides will be customized according to sequences specified by NCATS. The antisense oligonucleotides will be synthesized, purified using standard desalting methods, and normalized to the required quantity and concentration. The Standard Desalting material will be resuspended to 300 uL in PBS 7.4 (1x) buffer. The material will ship wet, at ambient temperature, in 0.5 mL Strle Tubes. Quantity: 1,200 nm Concentration: 4,000 uM Volume: 300 uL ESTIMATED PERIOD OF PERFORMANCE: Period of performance is 2 weeks ARO CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME) DETERMINATION The determination by the Government to award a contract without providing for full and open competition is based upon the market research conducted. Specifically, IDTDNA, Integrated DNA Technologies, Inc. 1710 Commercial Park, Coralville, Iowa 52241, USA is the only vendor in the marketplace that can provide the services required by NIDA . The intended source is: IDTDNA, Integrated DNA Technologies, Inc. 1710 Commercial Park, Coralville, Iowa 52241, USA CLOSING STATEMENT THIS SYNOPSIS IS NOT A REQUEST FOR COMPETITIVE PROPOSALS. However, interested parties may identify their interest and capability to respond to this notice. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. All responsible sources may submit a capability statement, proposal, or quotation which shall be considered by the agency. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Unique Entity ID (UEI), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. All responses must be received by the closing date and time of this announcement and must reference the solicitation number, 75N95023Q00398. Responses must be submitted electronically to Kaitlyn Landi, Contract Specialist, at kaitlyn.landi@nih.gov and KJ Shaikh, Contracting Officer, at kj.shaikh@nih.gov.� U.S. Mail and fax responses will not be accepted.
- Web Link
-
SAM.gov Permalink
(https://sam.gov/opp/a64d9f66bd584f589b7ddb01c2c41495/view)
- Record
- SN06713453-F 20230615/230613230110 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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