SOLICITATION NOTICE
A -- Preclinical Medications Screening in Dependence, Affect and Pain Models of Alcoholism
- Notice Date
- 6/7/2023 5:54:26 PM
- Notice Type
- Presolicitation
- NAICS
- 541715
— Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NICHD BETHESDA MD 20817 USA
- ZIP Code
- 20817
- Solicitation Number
- 75N94023R000010
- Response Due
- 7/27/2023 2:00:00 PM
- Archive Date
- 08/11/2023
- Point of Contact
- Patricia N. Hanacek, Phone: 3015946226
- E-Mail Address
-
hanacekp@mail.nih.gov
(hanacekp@mail.nih.gov)
- Description
- This notice follows Sources Sought Notice 75N4023R00010 released on April 24, 2023. It is issued in�advance of the Request for Proposal (RFP) No. 75N94023R00010 entitled, �Preclinical Medications�Screening in Dependence, Affect and Pain Models of Alcoholism� and is being issued on behalf of the�National Institute on Alcohol Abuse and Alcoholism (NIAAA) by the National Institute of Child�Health and Human Development (NICHD), Office of Acquisitions, NIH, DHHS. THIS IS A PRESOLICIATION NOTICE ISSUED IN ADVANCE OF THE REQUEST FOR PROPOSAL. THIS IS A RESEARCH�AND DEVELOPMENT (R&D) CONTRACT REQUIREMENT and is NOT an NIH grant opportunity. Description: NIAAA supports a preclinical medication efficacy testing program to foster validation of medication�targets and discovery of lead compounds relevant to AUD therapeutics. The current contract,�HHSN275201800006C, with the Louisiana State University Health Science Center (LSUHSC) was awarded�in 2018 as a one-year base contract with four (4) 12-month option periods. It supports medication�testing on measures of alcohol drinking, negative affect, and pain using in the chronic�intermittent ethanol (CIE) vapor exposure model in rats and expires September 26, 2023. To address the present and anticipated future needs of NIAAA�s Medication Development Program, the�LSUSC contract is being recompeted to continue supporting work within the same scope, i.e.,�medication testing in rats using the CIE model and alcohol drinking, pain, and negative affect�measures. It will implement the testing capacity of 2-3 compounds per year over the next five�years. The contract will use mechanisms having intellectual property conditions favorable to�compound providers when acquiring compounds from industry. This will eliminate a major barrier to�testing optimized compounds and will stimulate interest by the pharmaceutical industry in�developing high quality, marketable compounds for alcoholism. The data generated will be used in� the identification of compounds for further development. The requirements within this statement of work (in attached SOW) are considered severable for the�base and each 12-month option period. The goals of the proposed contract are: � �To assess compounds effects in standardized models of elevated alcohol intake in rats exposed to�chronic intermittent ethanol. � �To assess compound effects on negative affect and pain measures in alcohol dependent�rats. � �To collect, analyze, and display test data and report them to designated NIAAA� personnel. Animal Care and Use: The Offeror shall establish and provide resources for an animal care and use�program that is managed in compliance with applicable federal, state, and local laws and�regulations, such as: � �Animal Welfare Regulations (9 CFR, 1985/1989)� https://www.nal.usda.gov/awic/final-rules-animal-welfare-9-cfr-parts-1-2-and-3 � �Guide for the Care and Use of Laboratory Animals 8th ed., National Research Council,�2011 http://www.ncbi.nlm.nih.gov/books/NBK54050/ Public Health Service Policy on Humane Care and Use of Laboratory Animals, revised 2015. https://grants.nih.gov/grants/olaw/references/phspol.htm. To demonstrate compliance with the above policies and guidance, Offerors shall submit with their�Technical Proposal: 1) a copy of your organization�s most recent letter from NIH�s Office of�Laboratory Animal Welfare (OLAW) documenting approval of a valid Animal Welfare Assurance, and 2) a�copy of your organization�s most recent USDA Animal Welfare Act registration certificate. The solicitation is anticipated to result in a single cost-reimbursement contract award. The�duration of the contract will be a one-year base period, with four subsequent one-year option�periods, for a total period of performance of five years. Award is anticipated on or about September 27, 2023. The NAICS code for this acquisition is 541715, Research & Development (R&D) in the Physical,�Engineering, and Life Sciences, which has a size standard of 1,000 employees. THIS ACQUISTION IS�UNRESTRICTED (NOT A SET-ASIDE FOR SMALL BUSINESSES). Place of Performance: The place of performance will be the Contractor�s work site. Set Aside Status: None. The solicitation, RFP 75N94023R00010 with the specifics of the project, as well as information�pertinent to the development of an offeror's proposal, will be available electronically through the�SAM.Gov website at: https: //sam.gov/. It is anticipated that electronic release of the�solicitation will be on or about June 27, 2023, and will be due at 5:00 PM EST on or about July 27,�2023. No paper solicitation will be available. All information required for submission of a proposal will�be contained in the electronic Request for Proposal (RFP) package. No collect calls will be�accepted, nor will facsimile transmissions be accepted. It is the offeror�s responsibility to�monitor the above-mentioned sites for release of the solicitation and any amendments. All qualified�organizations are encouraged to respond with a contract proposal which shall be considered by the�agency. POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITIATION AND FOR�ROUTINELY CHECKING THE SITE FOR ANY AMENDMENTS THAT MAY BE ISSUED. FAILURE TO DO SO WILL BE AT THE�FIRM�S OWN RISK. ALL INQUIRIES SHALL BE SUBMITTED ELECTRONICALLY TO THE CONTRACTING OFFICER LISTED�AS THE POINT OF CONTACT HEREIN. This advertisement does not commit the United States Federal Government to award any contract�pursuant to this announcement nor pay for any costs associated with preparation and submission of a proposal. �
- Web Link
-
SAM.gov Permalink
(https://sam.gov/opp/744b09911b164078bf49b45ae1de9e91/view)
- Place of Performance
- Address: USA
- Country: USA
- Record
- SN06707046-F 20230609/230607230111 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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