SOURCES SOUGHT
Q -- Genotyping Services for Transgenic Rats and Mice for HIV Project
- Notice Date
- 6/1/2023 5:45:03 PM
- Notice Type
- Sources Sought
- NAICS
- 541380
— Testing Laboratories
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- 75N95023Q00368
- Response Due
- 6/16/2023 1:00:00 PM
- Archive Date
- 07/01/2023
- Point of Contact
- Rob Bailey, Phone: 3014517586, Josh Lazarus, Phone: 3018276923
- E-Mail Address
-
Rob.Bailey@nih.gov, josh.lazarus@nih.gov
(Rob.Bailey@nih.gov, josh.lazarus@nih.gov)
- Description
- The Government is seeking Capability Statements on behalf of The National Institute on Drug Abuse (NIDA) Intramural Research Program (IRP) from Other Than Small Business (OTSB) organizations under the North American Industry Classification System (NAICS) code 541380, that can provide genotyping services to genotype hundreds of novel transgenic rats and mice that will be generated at the NIDA IRP. This genotyping service requires rapid efficient service with a low error rate to allow for breeding multiple lines of animals without overloading capacity at NIDA�s animal facilities. This is a Sources Sought Notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of qualified business sources for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method. The established NAICS code is 541380, Testing Laboratories and Services. The U.S. Small Business Administration establishes a size standard for 541380 as $19,000,000 in revenue or less. BACKGROUND INFORMATION AND OBJECTIVE: The National Institutes of Health (NIH) is the nation�s leading medical research agency and the primary federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people�s health and save lives. The National Institute on Drug Abuse (NIDA) Intramural Research Program (IRP) is part of the NIH which mission is to conduct state-of-the-art research on basic mechanisms that underlie substance use disorders (SUDs), and to develop new methods for the treatment of SUDs. Research is supported at the molecular, genetic, cellular, animal, and human clinical levels and conceptually integrates highly innovative strategies and techniques. The long-term goal of the research is to better understand the biological and behavioral factors contributing to initiation, maintenance, and elimination of SUDs (and associated diseases), and to translate this knowledge into improved strategies for prevention, treatment, and reduction of negative consequences for the individual and for society caused by substance use disorders. The HIV special project is in need of genotyping services to genotype hundreds of novel transgenic rats and mice that will be generated at the NIDA IRP. To accomplish this workload and maintain new animal lines, the Molecular Mechanisms of Cellular Stress and Inflammation (MMCSI) Section of the Integrative Neuroscience Branch (INB)is requesting genotyping services. To support this requirement, rapid efficient service with a low error rate is necessary for breeding multiple lines of animals without overloading capacity at NIDA�s animal facilities. High quality genotyping results with a 72-hour tum-around time are vital to rat and mice colony population management, breeding schemes, and researcher animal study proposals. Given the number of investigators whose research is dependent upon rodent studies, eliminating mistakes (variables) in genotype testing is critical to the research mission at the NIDA/Intramural Research Program (IRP). PROJECT REQUIREMENTS: Independently and not as an agent of the Government, the Contractor shall demonstrate their capability to furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the�following: The Genotyping Support contractor shall demonstrate the ability to provide for DNA extraction and multi-gene analysis from submitted specimens and accompanying bioinformatics support. Sample storage and preservation are recognized as a critical component for subsequent nucleic acid analysis. Contractors must demonstrate their capacity and ability to hold samples until requested for return to the NIDA Contracting Officer Representative (COR) or NIDA Investigator, for a minimum of six months. The contractor shall demonstrate experience in ensuring that genotyping services will be performed in a timely manner with a low error rate. The Contractor shall thoroughly demonstrate their capability to provide genotyping services during a 12-month period with explicit responses as to their experience and capability to meet the following requirements: Perform high quality DNA extraction on submitted rodent tissue samples. Design Polymerase chain reaction (PCR) assays to perform genotyping analysis for all strains submitted. Run PCR analysis on samples, some of which may only require 1 gene to be analyzed and others may require multiple genes (unlimited cap on alleles) to be analyzed. Genotyping results must be provided with a 99.9% accuracy. The contractor is required to perform quality assurance analysis on 1% of submitted samples weekly. The government will not incur additional cost if sample submitted has multiple genes. Re-test any failed sample/reactions or questionable results at no additional cost to NIDA. Provide reproducible genotyping assay for each strain, if requested. Provide any raw data obtained in genotyping analysis, if requested. Analyze all PCR results and provide annotation (e.g., homozygous, heterozygous, etc.) Provide bioinformatics database that allows for NIDA investigators to quickly access test results. Securely send results to NIDA personnel for upload into their transgenic breeder database. Genotyping results shall be completed within 72 hours of receipt of samples. Hold all samples and remaining tissue for a minimum of 6 months at no additional cost. Provide sample collection and storage material (supplies) to the NIDA animal colony for tissue collection. All shipping and courier related cost to receive samples from NIDA shall be at no additional cost to the government. Samples should be sent overnight express or picked up from NIDA at least 3 times per week. Interested organizations must demonstrate and document in the submitted capability statement extensive experience in the areas listed above. INSTRUCTIONS: Capability statement /information sought. Companies that believe they possess the capabilities to provide the required product/service should submit documentation of their ability to meet each of the project requirements to the Contracting Officer. The capability statement must specifically address each of the project requirements separately. Additionally, the capability statement should include 1) the total number of employees, 2) the professional qualifications of personnel as it relates to the requirements outlined, 3) any contractor GSA Schedule contracts and/or other government-wide acquisition contracts (GWACs) by which all of the requirements may be met, if applicable, and 4) any other information considered relevant to this program. Capability statements must also include the Company Name, Unique Entity ID from SAM.gov, Physical Address, and Point of Contact Information. The response must include the respondents� technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. Interested companies are required to identify their type of business, applicable North American Industry Classification System (NAICS) Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number. The established NAICS code is 541380. Respondents must provide clear and convincing documentation of their capability of providing the products and support services specified in this notice. Also, information must be provided in sufficient details as to the respondents� (a) staff expertise, including their availability, experience, formal and other training; (b) capability to perform the work; (c) prior completed projects of similar nature; and (d) compliance with requirements: Vendors must identify and demonstrate specifically how they will meet the requirements listed above. Any other specific and relevant information about this particular area of procurement that would improve our consideration and evaluation of the information presented is desirable. Documentation may include, but not be limited to, contracts both Government and commercial the organization performed, references, i.e., names, titles, telephone numbers and any other information serving to document the organizations capability, e.g., awards, commendations, etc. The information submitted must be in an outline format that addresses each of the elements of the project requirement and in the capability statement paragraphs stated herein.� A cover page and an executive summary may be included but is not required. Any business concerns that believe they possess the capability necessary to successfully undertake the work described above must SUBMIT CAPABILITY STATEMENTS ELECTRONICALLY to the Contracting Officer, Josh Lazarus at josh.lazarus@nih.gov and Contract Specialist, Rob Bailey at Rob.Bailey@nih.gov, NO LATER THAN 4:00 p.m. EST on June 16, 2023. The Subject line for the submission should include this Sources Sought Number and organization name. NIDA will not accept paper or faxed capability statements. THIS NOTICE IS NOT A REQUEST FOR PROPOSALS.� This notice is for information and planning purposes only and does not commit the Government to any contractual agreement. This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization�s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published on SAM.gov. However, responses to this notice will not be considered adequate responses to a solicitation. CONFIDENTIALITY. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
- Web Link
-
SAM.gov Permalink
(https://sam.gov/opp/b3fd4abf443640bea304e82ec67c1c7b/view)
- Place of Performance
- Address: MD 20892, USA
- Zip Code: 20892
- Country: USA
- Zip Code: 20892
- Record
- SN06701964-F 20230603/230601230118 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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