SPECIAL NOTICE
99 -- TECHNOLOGY/BUSINESS OPPORTUNITY The 3DQ Microscope for Biological Imaging
- Notice Date
- 3/27/2023 8:55:56 AM
- Notice Type
- Special Notice
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- LLNS � DOE CONTRACTOR Livermore CA 94551 USA
- ZIP Code
- 94551
- Solicitation Number
- IL
- Response Due
- 3/27/2023 9:00:00 AM
- Archive Date
- 04/28/2023
- Point of Contact
- Genaro Mempin, Phone: 9254231121, Charlotte Eng, Phone: 9254221905
- E-Mail Address
-
mempin1@llnl.gov, eng23@llnl.gov
(mempin1@llnl.gov, eng23@llnl.gov)
- Description
- Opportunity: Lawrence Livermore National Laboratory (LLNL), operated by the Lawrence Livermore National Security (LLNS), LLC under contract no. DE-AC52-07NA27344 (Contract 44) with the U.S. Department of Energy (DOE), is offering the opportunity to enter into a collaboration to further develop its 3DQ-Scope for biomedical imaging. Background: Real-time 3D imaging is a major challenge for biological systems due to their dynamic nature and size.� Current solutions typically use 2D detectors; samples of interest are scanned and the subsequent 2D images then undergo deconvolution processing to enable 3D imaging.� This approach inherently has trade-offs including limitations to time resolution, imaging volume, and signal level.� To overcome these challenges, LLNL researchers have developed a novel 3D microscope that uses quantum-entangled light to provide volumetric imaging in a single exposure without scanning. Description: LLNL�s approach to the development of a wide-field, three-dimensional quantum (3DQ) microscope is to harness quantum entangled photons to form simultaneous 3D optical images, which could be a new paradigm for 3D volumetric imaging of biological specimens.� The 3DQ microscope is comprised of a novel optical system with highly sensitive detectors and an on-demand light source of entangled photons that will provide the necessary flux to enable live, scan-less 3D imaging.� By simultaneously measuring multiple dimensions of information from both partners of entangled photons pairs, LLNL�s 3DQ microscope would be able to collect fluorescence, fluorescence lifetime dark-field style (scattered photons) volumetric images at high frame rates. Furthermore, advancements in nanotechnology, photonic integrated circuits, and quantum photonics could make it possible for this technology to scale up to a CMOS-compatible platform for quantum-enabled on-chip contact fluorescence as well as lens-free tomography to enable portable, field-deployable and cost-effective solutions for biomedical research. Advantages/Benefits:� Capable of high resolution, widefield spectral fluorescence imaging in 3D High frame rates allow real-time 3D imaging of dynamic biological systems Volumetric imaging without the need for scanning the sample (3D information can be collected in a single exposure) Potential Applications:� Three-dimensional imaging of biological specimens at high frame rate with functionalities of fluorescence, fluorescence lifetime, or dark-field style (scattered light) imaging Development Status:� U.S. Patent No. 11,598,946 Widefield Three-Dimensional Microscopy with a Quantum Entanglement Light Source issueed 3/7/2023 Current stage of technology development:� TRL 2 LLNL is seeking industry partners with a demonstrated ability to bring such inventions to the market. Moving critical technology beyond the Laboratory to the commercial world helps our licensees gain a competitive edge in the marketplace. All licensing activities are conducted under policies relating to the strict nondisclosure of company proprietary information.� Please visit the IPO website at https://ipo.llnl.gov/resources for more information on working with LLNL and the industrial partnering and technology transfer process. Note:� THIS IS NOT A PROCUREMENT.� Companies interested in commercializing LLNL's 3DQ-Scope for biomedical imaging should provide a written statement of interest, which includes the following: 1.�������� Company Name and address. 2.�������� The name, address, and telephone number of a point of contact. 3.� � � � �A description of corporate expertise and/or facilities relevant to commercializing this technology. Written responses should be directed to: Lawrence Livermore National Laboratory Innovation and Partnerships Office P.O. Box 808, L-779 Livermore, CA� 94551-0808 Attention:�� IL-13533 Please provide your written statement within thirty (30) days from the date this announcement is published to ensure consideration of your interest in LLNL's 3DQ-Scope for biomedical imaging.
- Web Link
-
SAM.gov Permalink
(https://sam.gov/opp/95e70084140c49c3a4b557bd7521fe5c/view)
- Place of Performance
- Address: Livermore, CA, USA
- Country: USA
- Country: USA
- Record
- SN06630774-F 20230329/230327230104 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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