Loren Data's SAM Daily™

SAMDAILY.US - ISSUE OF MARCH 08, 2023 SAM #7771
SOLICITATION NOTICE

Q -- Library preparation, Illumina, RNA with PolyA selection

Notice Date

3/6/2023 6:44:21 PM
 

Notice Type

Combined Synopsis/Solicitation
 

NAICS

541380 — Testing Laboratories
 

Contracting Office

NATIONAL INSTITUTES OF HEALTH NCATS BETHESDA MD 20892 USA
 

ZIP Code

20892
 

Solicitation Number

75N95C23P00043
 

Response Due

3/13/2023 8:00:00 AM
 

Archive Date

03/28/2023
 

Point of Contact

Rhanda Lopez
 

E-Mail Address

rhanda.lopez@nih.gov
(rhanda.lopez@nih.gov)
 

Description

Alagille Syndrome (ALGS) is characterized by mutations in the JAG1 gene which lead to a variety of clinical symptoms, primarily bile duct paucity or the lack of proper bile duct formation. Hepatoblasts are bipotent cells that retain the ability to differentiate into either hepatocytes, the cell type that forms 85% of the liver, or cholangiocytes, the cells that form bile ducts. It is believed that haploinsufficiency of JAG1 affects this differentiation process resulting in a lack of cholangiocytes to form the growing bile duct network during fetal development. However, it is not clear if homogeneous (hepatoblast to hepatoblast) or heterogeneous (other cell to hepatoblast) JAG1 signaling is critical for this process. We aim to establish if homogeneous JAG1 signaling in patient-derived iPSC-generated hepatoblasts could drive differences in hepatoblast to cholangiocyte differentiation. To do this we will use RNA-seq to identify dysregulated pathways and biomarkers that should indicate if patient-derived hepatoblasts lack the ability to efficiently differentiate into cholangiocytes in comparison to control lines.�
 

Web Link

SAM.gov Permalink
(https://sam.gov/opp/b33bb201f35c4ecc8dee89f9ba9dafdd/view)
 

Place of Performance

Address: South Plainfield, NJ 07080, USA

Zip Code: 07080

Country: USA
 

Record

SN06609215-F 20230308/230306230103 (samdaily.us)
 

Source

SAM.gov Link to This Notice
(may not be valid after Archive Date)

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