SAMDaily.us | MOD | 65 | Acquisition of NMR equipment upgrades for existing 500MHz Bruker Avance NMR spectrometers

SAMDAILY.US - ISSUE OF JUNE 09, 2022 SAM #7496
MODIFICATION

65 -- Acquisition of NMR equipment upgrades for existing 500MHz Bruker Avance NMR spectrometers

Notice Date: 6/7/2022 11:08:56 AM
Notice Type: Sources Sought
NAICS: 334516 — Analytical Laboratory Instrument Manufacturing
Contracting Office: NATIONAL INSTITUTES OF HEALTH NICHD BETHESDA MD 20817 USA
ZIP Code: 20817
Solicitation Number: NICHD-22-133
Response Due: 6/13/2022 6:00:00 AM
Point of Contact: Amber Harris, Fax: 3014803278
E-Mail Address: amber.harris@nih.gov
(amber.harris@nih.gov)
Description: SOURCES SOUGHT NOTICE (Acquisition of NMR equipment upgrades for existing 500MHz Bruker Avance NMR spectrometers) AGENCY: �The National Institutes of Health, National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) TITLE: Acquisition of NMR equipment upgrades for existing 500MHz Bruker Avance NMR spectrometers PROPOSED SOLICITATION NUMBER: NICHD-22-133 PROJECT SERVICE CODE: 6515 - MEDICAL AND SURGICAL INSTRUMENTS, EQUIPMENT, AND SUPPLIES This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. There is no solicitation available at this time. The purpose of this notice is to obtain information regarding: (1) the availability and capability of all qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification according to the North American Industry Classification System, (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set- aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. BACKGROUND: Each NMR spectrometer comprises a superconducting magnet, a console that controls the generation, application and detection of radiofrequency pulses, and a probe (plus associated cryoplatform) that detects the NMR signal and transmits this to the console. In contrast to superconducting magnets which last effectively forever, technological improvements both in console and probe design significantly enhance capabilities and permit one to design ever more complex experiments that were not previously feasible. The 500 MHz NMR console we are seeking to upgrade are in excess of 12 years of age, and is no longer serviceable, and hence need upgrading. �Further, the upgrades to the latest generation of consoles will increase attainable signal-to-noise by 20%, reduce spectrometer artefacts and facilitate high quality data acquisition in samples where the solvent is predominantly H2O (as opposed to D2O). (Note most NMR data are acquired in H2O to permit observation of exchange backbone and sidechain amide groups). � All our NMR spectrometers are being used to push the frontiers of NMR spectroscopy in structural biology, with considerable emphasis being placed on the application of these methods to AIDS related structural problems. These include work on HIV-1 Gag polyprotein, HIV-1 reverse transcriptase, the fusion and cytoplasmic domains of HIV-1 gp41, HIV-1 integrase, HIV-1 protease, and various host proteins that are relevant to the pathogenesis of AIDS. The main objective of this acquisition is to provide the NIDDK with the following: (1)�� Bruker Avance Neo 500 MHz console for Bruker 500 MHz spectrometer (NIH decal number, 01730549. SALIENT / REQUIRED FEATURES AND SPECIFICATIONS: Independently, and not as an agent of the Government, the Contractor shall perform all of the detailed Task Areas listed below. Deliver Upgrade to 500 MHz NMR spectrometer that is compatible with the existing Bruker NMR spectrometer systems that the items will be part of. The Contractor shall accept a trade-in of an existing Avance III 500 console and provide a discounted price for the trade-in. The Bruker Avance Neo 500 MHz console must be compatible with the existing NMR spectrometer system that the item will be part of. The Avance Neo 500 console will replacing the existing Avance III 500 console (Bruker ID BH046704). NIH will re-utilize one of their existing Bruker 500 MHz NMR probes on the new console. This probe will be provided at the time of delivery to the Bruker engineer so that the console can be installed. Otherwise the console will be considered installed and accepted at the time of delivery. The selected probe will be bench marked on the existing console. The benchmarks will be reproduced or exceed on the new console. �� AV4500c (1PC): NMR CONSOLE AVANCE NEO 500 MHZ: The AVANCE NEO system console electronics is housed within a stainless steel one bay or double bay cabinet for 19-inch format units providing RF shielding with highest immunity against DVB-T, ATSC, ISDB-T, etc. The cabinet offers enough space to accommodate various units like Bruker RF amplifiers etc. -�� The system console incorporates a state-of-the-art Ethernet ROUTER providing up to 14 TCP/IP based Ethernet ports for internal and external spectrometer devices such as sample changers, CryoProbe platforms, magnet control and monitoring equipment, Solid State NMR accessories, etc. It is equipped with a Bruker Power Distribution Unit (PDU) to enable software controlled console power-up and power-down via TopSpin. -�� A dedicated system control unit (SCU) containing an embedded processing CPU with 1TB hard disk drive allows versatile and flexible spectrometer control. It controls the overall timing of system for all RF channels, gradient channels, real time pulses, triggers, etc. Each RF channel provides a fully broad banded transmit and a fully broad banded receive channel (transceiver TRX1200). -�� Bruker system characteristics (AQS): ?�� 80 MHz system clock, 12.5ns timing resolution ?�� Synchronicity on all channels within 12.5ns ?�� Gradient control for all Bruker gradient amplifiers ?�� Up to 8 RF channels ?�� Up to 4 trigger inputs with 12.5ns resolution ?�� Up to 4 real time output controls with 12.5ns resolution -�� Bruker Smart Magnet System (BSMS) supports: ?�� Ultra-stable, ultra-low noise B0 current source (ELCB) ?�� 2G Digital NMR Lock for 2H and/or 19F nuclei (L-TRX) ?�� Bruker Shim current sources (SCB20) -�� Bruker SmartVT control for up to 4 independent VT channels -�� Bruker SmartCoolers (e.g. BCU-I) -�� Bruker Low Temperature accessories (e.g. LN2 Exchanger) -�� Bruker High Temperature equipment (e.g. BVTE3900) -�� Bruker High Resolution gradient amplifiers (e.g. GAB/2) -�� Bruker RT Shim Systems and BST Upperparts �� Bruker preamplifier system (HPPR) supports: -�� Up to 8 RF preamplifiers -�� Fully Multi-receive, no extra wiring/components -�� Touch screen based human machine interface -�� Accurate tuning and matching with factory calibrated preamplifiers -�� Fully integrated automatic tuning and matching with ATM probes -�� Probe identification (PICS) interface # MAS rotor synchronization pre-configured # - AH0095 required for further trigger and real-time control options �� AH3002 (1PC):SHIM SYSTEM BOSS-3 SB PLUG -�� Bruker Standard Bore (SB) Magnet System high performance Matrix Orthogonal Shim System (BOSS-3 SB). Designed for optimum homogeneity at low current and with low heat dissipation. Features: ?�� 36 Matrix Shim Gradients ?�� B0 coil ?�� PT100 temperature sensor ?�� Identification coding (ID) �� AH3007 (1PC) SHIM UPPERPART BST SB Bruker Standard Bore (SB) Magnet System Sample Transfer (BST) for NMR sample insertion and ejection (SB Spinner supported). Features: ?�� Built-in sample-up sensor ?�� Built-in sample spinning/sample-down sensor ?�� Prepared for shim system cooling �� AH0243(2PC): Shim Current Board (SCB20) SCB20 is a high precision, ultra-stable shim current board. Depending on shim system type two units might be necessary # Compatible with all Bruker Orthogonal and Matrix shim systems (e.g. BOSS-3) Features ?�� 20 shim current sources ?�� 20Bit digital resolution each ?�� Shim current range +/- 1A each �� AH1206(1PC): BSMS GAB/2 for Z Gradients GAB/2 is a fast single channel gradient amplifier board prepared for pulsed field gradient shimming (TopShim) and single axis GRAdient enhanced SPectroscopy (GRASP). Its design offers offset-free operation without the need of blanking pulses. Features: ?�� 10A max. ?�� 16Bit resolution ?�� Pulslength up to 50ms per second ?�� Built-in pre-emphasis # TopShim uses lineshape optimization (see JMR 182(1), 38-48, 2006) # XYZ-gradient operation requires three GAB/2 units (see AH1204) �� AH1204(1PC): BSMS GAB/2 for XY Gradients Gradient amplifier package with 2 (two) GAB/2 units to extend single to triple axis Gradient enhanced SPectroscopy (GRASP). GAB/2 offers offset-free operation without the need of blanking pulses. # TopShim uses lineshape optimization (see JMR 182(1), 38-48, 2006) # XYZ-gradient operation requires three GAB/2 units (see AH1206) Features GAB/2:� ?�� 10A max. ?�� 16Bit resolution ?�� Pulslength up to 50ms per second ?�� Built-in pre-emphasis �� AH1015(1PC): VT Control Unit (BSVT) The Bruker SmartVT (BSVT) is a highly integrated gas flow system to control NMR sample lift (inject/eject) and VT temperatures within the probe. Features: ?�� Digital temperature sensor resolution better than 5 mK ?�� Excellent temperature stability of about 10 mK/K (*) ?�� Supports various temperature sensors (e.g. thermocouple T or E, PT100) ?�� Mass-flow based VT gas flow control and monitoring, up to 3000 l/h ?�� Built-in sample freeze protection together with CryoProbes ?�� Up to 4 independent heater channels (e.g. Flow probes) ?�� High Temperature NMR ready (> 300�C with HT NMR probes) ?�� Supports SmartCoolers (BCU) and LN2 Low Temperature accessories ?�� Easy sample insertion with different kinds of spinner (ceramic, KEL-F, etc.). ?�� NMR Thermometer: accurate in-tube sample temperature determination # (*) e.g. SmartProbe, depends on environment and probe type �� BH3072(1PC): BSMS 2H Lock RF Unit (L-TRX) The L-TRX is a highly integrated 2H lock RF transceiver (transmit and receive) unit with incorporated 5W RF amplifier for field lock operation on deuterated solvents. Features: ?�� Versatile DDS based 2H frequency RF generation ?�� Fast and accurate gradient shimming on 2H using TopShim ?�� Easy and reliable locking with complex deuterated solvents and this even in automation with e.g. Pyridine-d5 ?�� NMR Thermometer: accurate in-tube sample temperature determination # Can be extended with 19F lock RF unit (BH1230) for 19F lock operation �� BH2075 (4PC): �RF CHANNEL (TRX1200) �The TRX1200 is a highly integrated NMR RF transceiver (transmit and receive) unit with built-in pulse program engine (Sequencer, NCO/DDS, Shapes, etc.). Features: ?�� 5 to 1200 MHz (transmit and receive) ?�� 12.5ns timing resolution ?�� 12.5ns simultaneous setting of amplitude & phase & frequency ?�� 1GB sequencer waveform memory ?�� 1852 MHz high intermediate frequency (IF) ?�� up to 7.5 MHz spectral width ?�� digital resolution (effective dynamic range) o�� 17 Bit (SWH < 5 MHz) o�� 19 Bit (SWH < 1 MHz) o�� 23 Bit (SWH < 6 kHz) ?�� 240 MSPS / 16 Bit ADC, Digital Down Converter (DDC) ?�� 960 MSPS DAC, Digital Up Converter (DUC) �� BH3401 (1PC): �RF Amplifier BLABBH2H500/100/150, The BLABBH2H500/100/150 is a linear triple channel high RF power amplifier for X-nuclei, 1H (and 19F), and 2H observe and decoupling. It incorporates a fast deuterium 2H lock switch to enable fast switching between 2H decoupling and 2H lock operations. It has a built-in ethernet interfaced, computer controlled RF amplifier safety with forward/reflected RF power monitoring and diagnostics. Frequency ranges of BLABBH2H500/100150 models are Model �� BB-Channel�� H-Channel �� 2H-Channel 200-600 �� 15-600MHz (A1) 180-600 MHz (A2) 30-92 MHz(A3) 700-900 �� 15-600MHz (B1) 650-900 MHz (B2) 105-140 MHz (B3) 950-1000 �� 15-600MHz (C1) 890-1000 MHz (C2) 145-155 MHz(C3) Features: ?�� RF power A1: Min. 500W RF peak power (max. 50W CW) A2: Min. 100W RF peak power (max. 25W CW) A3: Min. 150W RF peak power (max. 15W CW) B1: Min. 500W RF peak power (max. 50W CW) B2: Min. 100W RF peak power (max. 25W CW) B3: Min. 250W RF peak power (max. 25W CW) C1: Min. 500W RF peak power (max. 50W CW) C2: Min. 100W RF peak power (max. 25W CW) C3: Min. 250W RF peak power (max. 25W CW) - Pulse program controlled blanking �� BH3420 (1 PC): RF Amplifier BLABB500, The BLABB500 is a linear single channel high RF power amplifier for Xnuclei observe and decoupling. It provides two identical RF outputs connecting to different preamplifiers when appropriate (no manual rewiring). It has a built-in ethernet interfaced, computer controlled RF amplifier safety with forward/reflected RF power monitoring and diagnostics. Frequency range of BLABB500 model is: Model BB-Channel 200-600 15-600MHz Features: ?�� RF power: Min. 500W RF peak power (max. 50W CW) ?�� Pulse program controlled blanking # Note: # - for NMR instruments up to 1.2 GHz # - covers all X-nuclei within the frequency range �� BH0264 (1PC): HPPR HPLNA 1H Preamplifier The HPLNA 1H is a highly linear, low noise, GaAs FET transistor technology based preamplifier for 1H and 19F observe, 1H and 19F decoupling and 19F lock operation. Features: ?�� Ultralow ~1.0dB system noise figure ?�� Max. 4kW peak power RF capability ?�� Active transmit/receive switch ?�� Built-in RF power detector ?�� Factory calibrated for accurate tuning and matching �� BH0243 (1PC): HPPR 2H Preamplifier, The HPPR 2H is a linear, low noise, GaAs FET transistor technology based preamplifier for 2H observe, 2H decoupling and 2H lock operation. Features: ?�� Very low ~1.4dB system noise figure ?�� Max. 500W peak power RF capability ?�� Active transmit/receive switch ?�� Fast, pulse program controlled mode switching ?�� Built-in RF router for 2H lock and 2H observe ?�� Factory calibrated for accurate tuning and matching # No external filters required �� BH0269 (1PC): HPPR XBB19F 2H PASS Preamplifier The HPPR XBB19F 2HP (2H pass) is a linear, low noise, GaAs FET transistor technology based preamplifier for observe and decoupling of nuclei from 57Fe up to 19F with built-in 1H Stop RF filter. Features: ?�� Very low ~1.4dB system noise figure ?�� Max. 500W peak power RF capability ?�� Active transmit/receive switch ?�� Factory calibrated for accurate tuning and matching # Designed for broad banded High Resolution NMR probes �� BH0245 (1PC) HPPR 13C Preamplifier The HPPR 13C is a linear, low noise, GaAs FET transistor technology based preamplifier for 13C or 79Br observe and decoupling operation. Features: ?�� Very low ~1.4dB system noise figure ?�� Max. 500W peak power RF capability ?�� Active transmit/receive switch ?�� Factory calibrated for accurate tuning and matching # No external filters required �� BH0247 (1PC) HPPR 15N Preamplifier The HPPR 15N is a linear, low noise, GaAs FET transistor technology based preamplifier for 15N observe and decoupling operation. Features: ?�� Very low ~1.4dB system noise figure ?�� Max. 500W peak power RF capability ?�� Active transmit/receive switch ?�� Factory calibrated for accurate tuning and matching # No external filters required �� BH0266 (1PC): HR NMR RF FILTER 2H Stop 2H Stop RF Filter to be used together with broad banded High Resolution NMR RT probes. Features: ?�� Stop Band: 2H ?�� Pass Band: 19F - 75As, 17O - 57Fe �� PCLIN (1PC): NMR Workstation (LINUX), Configured NMR Workstation for AVANCE NEO NMR spectrometer series. Features (*): ?�� Intel Xeon E5-1620v4 (up to 3.8 GHz), Quad Core ?�� 16GB DDR4-2133 (2x8 GB) RAM ?�� NVIDIA Quadro K620 2 GB GFX graphics card ?�� 2TB 7200 RPM SATA HDD ?�� Integrated Intel I-218 Gbit LAN (SPECT) ?�� Intel Ethernet I210-T1 PCIe NIC (NET) ?�� 9.5 mm Slim SuperMulti DVDRW 1st ODD ?�� USB US-Keyboard and USB mouse ?�� Preinstalled CentOS 7 (64 Bit) and TopSpin 4.x (w/o license) # (*) Configuration can change without prior notice �� AP2521 (1PC): NMR WS MONITOR 24"" LCD 24"" TFT Monitor for NMR Workstations. �� SHTS000-04 (1PC) TopSpin 4.x Basic license, TopSpin4 NMR Software - Acquisition and Processing License. This software offers the full operating capability for spectrometer control, data acquisition (arbitrary dimensions) and processing (1D, 2D, 3D, 4D / nD) . capability for NMR data for WINDOWS, LINUX or MAC. Features: ?�� NMR acquisition in arbitrary dimensions, with guided acquisition setup ?�� NMRGuide for training of users in use of 1D and 2D, 132 experiments with NMR literature library ?�� IconNMR automation interface ?�� NMR data processing (1D, 2D, 3D, 4D and 5D) ?�� Processing of Non Uniformly Sampled (NUS) data for 2D spectra (basic version) ?�� Integration and deconvolution of NMR spectra ?�� NMRSIM and DAISY for experiment simulation and 1D and 2D spectra prediction ?�� Relaxation analysis (T1/T2), solid state lineshape analysis ?�� TopSpin integrated structure editor # License key only (software available for download from our webserver) �� AH0039 (1PC): BSVT Adaptor Type-T (standard probes), TC-T VT Adapter for NMR probes with Thermocouple type 'T' temperature sensors. Features: ?�� Probe Thermocouple type T interface (2x) ?�� Probe heater interface ?�� Probe heater safety sensor interface # For Standard Temperature NMR probes (up to 200�C) # Not required for iProbes (built-in VTA) �� AH0034 (1PC): BSVT Adaptor BTO (Probehead with BTO) VTA BTO (VT adapter) for NMR probes with BRUKER BTO-2000 style temperature sensors. Features: ?�� Probe BTO-2000 interface ?�� Probe heater interface ?�� Probe heater safety sensor interface # For Standard Temperature NMR probes (up to 200�C) # Not required for iProbes (built-in VTA) �� AH0016 (1PC): VT GAS COOLER (BCU-I), The SmartCooler (BCU-I) is a chiller for VT gas cooling of NMR probes. Achievable temperature within the probe depends on probe and selected VT gas flow but may be as low as ~0 �C. �� Features: ?�� VT gas temperature about -40 �C (at the end of the transferline) ?�� Up to 3000 litre per hour # Requires dry VT gas with at least -50 �C (at 1 bar) dew point temperature �� SHNS100A-04 (1PC): NUS-Professional license (ACA) Soft Lic NUS Prof. Proc. Pckge ACA Task Area 1 � shipping instructions The Contractor will ship the Bruker Avance Neo 500 MHz console to Bldg 6/Rm B1-27, 9000 Rockville Pike, Bethesda, MD 20892, within 5 - 6 Months ARO. �The items will be shipped Delivered Duty Paid (DDP) destination. �Payment terms, net due in 30 days ARO. This Sources Sought is for an organization or institution to provide the NIDDK with Bruker Avance Neo 500 MHz console for Bruker 500 MHz spectrometer (NIH decal number, 01730549). �The purchase of this instrument is necessary to maintain the high quality of our research. � All qualified small businesses, whether they are small businesses; HUBZone small businesses; service-disabled, veteran owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; interested in submitting a corporate capability statement should demonstrate their capability to provide equipment that meets the characteristics below. SPECIAL INSTRUCTIONS: This acquisition is being conducted under the authority of FAR Part 13.5 Simplified Acquisition Procedures. This is a competitive requirement conducted under the authority of FAR 52.211-6, Brand Name or Equal. �This is a requirement for BRUKER BIOSPIN CORP NMR equipment upgrades for existing 500MHz Bruker Avance NMR spectrometers. � The vendor will be evaluated on their quoted product meeting the specifications under section SALIENT / REQUIRED FEATURES AND SPECIFICATIONS. If you or your firm/business has an interest and possess the required expertise we invite you to submit a corporate capability statement to assist the Government in determining in accordance with Federal Acquisition Regulation (FAR) 19.502-2(b) whether or not this procurement will be set-aside for any of the programs described above. The associated NAICS code is 334516, Analytical Laboratory Instrument Manufacturing, and the small business size standard is 1,000. �All respondents are requested to identify their firm's size and type of business. Interested firms responding to this Sources Sought Notice should adhere to the following: (a) Provide a capability statement demonstrating relevant experience, skills and ability to fulfill the Government's requirements for the above. The capability statement should contain sufficient detail for the Government to make an informed decision regarding your capabilities. The capability statement should not exceed 15 pages using a font size 10 or larger. (b) Small business concerns that possess the capabilities necessary to undertake the efforts should submit complete documentation of their capabilities to the Contracting Officer. This capability statement should include: 1) the total number of employees, 2) the professional qualifications of scientists, medical experts, and technical personnel as they relate to the requirements, 3) a description of general and specific facilities and equipment available, including computer equipment and software, and 4) any other specific and relevant information that would improve the Government's consideration and evaluation of the information presented. Further, Past Performance documentation, which should include, but not be limited to, a minimum of two (2) contracts performed for either Government or commercial organizations shall be provided. References shall include for each contract: names, titles, contract number, total price or cost, telephone numbers of government Contracting Officer Representative and Contracting Officers. (c) All capability statements sent in response to this Small Business Sources Sought notice must be submitted electronically (via email) to the Point of Contact below in MS Word or Adobe Portable Document Format (PDF). The subject line must specify NICHD-22-133. Facsimile responses will not be accepted. Electronically submitted capability statements are due no later than 9:00 AM (Eastern Prevailing Time) seven (7) calendar days (including date of submission to https://beta.sam.gov) after posting of the Small Business Sources Sought Notice. CAPABILITY STATEMENTS RECEIVED AFTER THIS DATE AND TIME WILL NOT BE CONSIDERED This notice is for information and planning purposes only and is not to be construed as a commitment by the Government, nor will the Government pay for information solicited.
Web Link: SAM.gov Permalink
(https://sam.gov/opp/d09c3fe5e1fe4be9b149f80f3457b87b/view)
Place of Performance: Address: Bethesda, MD 20892, USA; Zip Code: 20892; Country: USA
Record: SN06349469-F 20220609/220607230056 (samdaily.us)
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65 -- Acquisition of NMR equipment upgrades for existing 500MHz Bruker Avance NMR spectrometers