SPECIAL NOTICE
99 -- Stereomicroscopes from Leica
- Notice Date
- 4/29/2022 9:30:59 AM
- Notice Type
- Special Notice
- NAICS
- 333314
— Optical Instrument and Lens Manufacturing
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH OLAO BETHESDA MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- NIH-OLAO-OD5-NOI6318080
- Response Due
- 5/5/2022 6:00:00 AM
- Point of Contact
- Ryan Alexander
- E-Mail Address
-
ryan.alexander@nih.gov
(ryan.alexander@nih.gov)
- Small Business Set-Aside
- SBA Total Small Business Set-Aside (FAR 19.5)
- Description
- Leica Microsystems S9 E� Stereomicroscope and M165 FC NIH-OLAO-OD5-NOI6318080 The National Institutes of Health intends to award a Firm-Fixed-Price purchase order to Leica Microsystems equipment 1700 Leider Lane, Buffalo Grove, IL 60089 for the acquisition of Leica S9 E Stereom, Leica M165 FC Lei equipment. In accordance with FAR Part 6.302-1, the Contractor is the only known responsible source who can provide the subscription service as no other source has been identified who can provide the requirement listed below. The mission of the Pediatric, Genetic and Developmental Eye disease section of the Ophthalmic Genetics and Visual Function Branch (OGVFB) at National Eye Institute is to conduct research on morphogenesis of the eye during embryo development and specifically during optic fissure closure. Failure of the optic fissure to close during 5th week of human gestation result in a potentially blinding congenital ocular disorder known as Uveal Coloboma. The goal is to utilize multidisciplinary approaches encompassing areas such as molecular genetics, stem cell biology, cell signaling, and animal model systems to understand the genes and genetic networks involved in the process of optic fissure closure during development of the eye. Specific areas of research include, but are not limited to, studies on loss of gene function in transgenic reporter lines, cell migration studies in fluorescently labeled optic cells by live in-vivo imaging using zebrafish as a model system to identify genes involved in the process and their association with biochemical signaling pathways. Leica S9 E Stereomicroscope, and Leica M165 FC Fluorescent stereomicroscope are manufactured by Leica microsystems will facilitate our embryo screening and injection procedure and provides high quality microscopic images for phenotypic analysis to examine expression of reporter genes in various cell types and in specific tissues during embryogenesis. This will benefit the identification of genes and their interaction with cellular signaling pathways that regulate optic fissure formation and closing mechanism during embryogenesis.� As the developer of this proprietary technology, Leica Microsystems is the sole manufacturer and provider of the M165FC microscope and all of its supporting programs and components. Leica has a GSA contract for all of the parts listed in this quotation, and they are the sole supplier through GSA or elsewhere of this equipment. This is supported by a Google search for the terms �Leica M165FC� 4/29/22 which returns Leica as the only vendor of new (rather than used) equipment in the US. The M165FC microscope has been configured to perfectly meet the imaging needs of our unit. Zoom range of 7.3x to 120x: enables a field-of-view covering a broad range of embryos for sorting purposes, up to organ-level magnification to live-imaging of embryonic phenotypes. Binoc ErgoTube with variable 10 to 50-degree viewing angle: this feature is required for healthier ergonomic viewing conditions during our long animal assays, and is ideal for a multi-user environment. This significantly reduces the risk of repetitive strain injuries and is unavailable on other systems. Triple Beam � fluorescent illumination technology provides even fluorescence illumination and fully apochromatic correction for accurate color rendition; this enables imaging uneven and dim fluorescent expression in transgenic zebrafish. In combination with the bright LED3 lightsource and collection of filter sets selected, this will enable imaging of transgenic lines that would be difficult on other systems. This technology is unavailable on other systems. Rotterman contrast, brightfield, and darkfield options of TL3000 base are ideal for providing even illumination with proper contrast for imaging zebrafish embryos. These settings can be precisely recalled via built-in hardware encoding when replicating experiments. This base is unavailable on other systems. Working distance of over 6 cm enables easy dissection and embryo manipulation under the microscope. Encoded imaging parameters (including zoom level, camera settings, and full recording of illumination settings) and click-stop zoom options will enable accuracy and reproducibility of results. The S9E microscope has been configured to perfectly meet the imaging needs of our unit. The most essential feature for fast and accurate manipulating zebrafish embryos under this stereomicroscope is the 9:1 zoom with magnification 6.1x-55x (10x eyepieces, no supplementary lens) and the field of view up to 37.6mm. TL3000 Ergo base is very ergonomic, an essential feature as researchers can spend many hours at a time using it. Synergy of above stereomicroscope solutions: Critically, these instruments provide continuity of existing laboratory protocols. Imaging is currently performed on Leica stereomicroscopes and consistency of data acquisition is key for ongoing studies. Modular approach of Leica stereomicroscopes will allow for addition of functionality in the future if it becomes necessary for our work. Additionally, many of these stereomicroscope components are compatible with and readily transferrable to/from our existing Leica stereomicroscopes, including M80 and M205FCA. This level of modularity is unavailable on other systems. Ergonomic features (Ergo Binoc, Ergo base) protect the user from repetitive stress injuries during long instrument sessions. Costly hardware components (i.e., light sources and cameras) from existing instruments are readily transferable between instruments as-needed depending on the application. This enhances the overall flexibility and modularity provided. This level of modularity is unavailable on other systems. Leica LAS X provides a consistent software interface across all instruments (stereo, widefield, confocal). This will reduce time investment needed for new-employee training or training refreshers. The instruments will be supported by a single vendor which has a well-established presence on the NIH campus in Bethesda. This in-person support availability (as well as remote support 8am-8pm, Mon-Fri) will reduce or mitigate any potential instrument down time. This consistent level of on-campus presence is unmatched by other vendors. This notice is not a request for competitive quotes.� However, any party that believes it can provide the Leica S9 E Stereomicroscope, and Leica M165 FC Fluorescent stereomicroscope manufactured by Leica microsystems product as stated herein may submit a written capability statement that clearly supports and demonstrates their ability to perform the requirement. Responses to this notice shall contain sufficient information to establish the interested parties� bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size.� A determination by the Government to compete this proposed award based upon responses to this notice is solely within the discretion of the Government. In order to be considered for an award, an offeror must have completed the online electronic Representations and Certifications located at https://www.sam.gov in accordance with FAR 4.1201(a). By submission of an offer, the offeror acknowledges the requirement that a prospective awardee shall be registered in SAM at https://www.sam.gov/ prior to award, during performance, and through final payment of any contract, basic agreement, basic ordering agreement, or blanket purchasing agreement resulting from this solicitation (Lack of registration in the System for Award Management will make an offeror ineligible for award).� All responsible sources may submit an offer that may be considered by the Agency. It is anticipated that an award will be issued approximately five (5) days after the date of this notice unless the Government determines that another organization has the capability to meet this requirement. Please email responses to ryan.alexander@nih.gov no later than 9:00 a.m. EST on Thursday, May 5, 2022.�
- Web Link
-
SAM.gov Permalink
(https://sam.gov/opp/bc572af154814a1689e30af9a6d64205/view)
- Place of Performance
- Address: Bethesda, MD 20892, USA
- Zip Code: 20892
- Country: USA
- Zip Code: 20892
- Record
- SN06312437-F 20220501/220429230056 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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