SOLICITATION NOTICE
65 -- Mouse Conditional Knockout Project
- Notice Date
- 5/25/2021 3:07:06 PM
- Notice Type
- Presolicitation
- NAICS
- 325414
— Biological Product (except Diagnostic) Manufacturing
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NICHD BETHESDA MD 20817 USA
- ZIP Code
- 20817
- Solicitation Number
- NICHD-21-109
- Response Due
- 6/10/2021 2:00:00 PM
- Archive Date
- 06/25/2021
- Point of Contact
- Jacob Balenson, Phone: 3018278302
- E-Mail Address
-
jacob.balenson@nih.gov
(jacob.balenson@nih.gov)
- Description
- The National Institutes of Health, National Institute of Child Health and Development (NICHD)� intends to award a purchase order without providing for full and open competition to Cyagen US INC., 2255 Martin Avenue, Suite E, Santa Clara, CA. 95050, USA, for generation of conditional knock-in/out mouse lines. Our research focuses on the development of the mammalian hematopoietic system. A long-term area of interest for our laboratory is the study of signal transduction molecules and pathways that regulate T lymphocyte maturation in the thymus. Currently, we are analyzing transgenic and conditional nonsignaling mutants of T cell antigen receptor (TCR) signaling subunits to evaluate the importance of individual TCR signaling chains and motifs at specific stages of T cell development and in mature T cells. We are also using gene profiling to identify proteins that are important for fine-tuning the T cell�signaling response in developing and mature T lymphocytes. In conjunction with checkpoint inhibitors for immunotherapy in humans, these molecules may also be targets. We are also investigating the function of new T cell�specific proteins that we identified by subtraction library screening. We have identified two gene candidates: LAX1 and SIT1, that we would like to make conditional knockin/knockout mouse models of to future investigate. LAX1 and SIT1 are involved in the T cell receptor pathways and are genes that are related to our ongoing Themis 1 & 2 and 6Y/6F projects in the lab. The Government needs services for�generation of conditional knock-in/out mouse lines. Please see attached�Pre-Solicitation NICHD-21-109.
- Web Link
-
SAM.gov Permalink
(https://beta.sam.gov/opp/3a55a8e196b74a099dd2e2a9c3e1b9ea/view)
- Place of Performance
- Address: Bethesda, MD 20892, USA
- Zip Code: 20892
- Country: USA
- Zip Code: 20892
- Record
- SN06012567-F 20210527/210525230104 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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