SPECIAL NOTICE
Q -- Kidney Biopsies in Diabetic Kidney Disease
- Notice Date
- 9/17/2020 5:48:44 PM
- Notice Type
- Justification
- NAICS
- 541380
— Testing Laboratories
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NICHD BETHESDA MD 20817 USA
- ZIP Code
- 20817
- Solicitation Number
- NICHD-20-044
- Archive Date
- 10/18/2020
- Point of Contact
- Amber Harris
- E-Mail Address
-
amber.harris@nih.gov
(amber.harris@nih.gov)
- Award Number
- 75N94020P00147
- Award Date
- 04/03/2020
- Description
- The Chronic Kidney Disease Section focuses on the mechanisms of diabetic kidney disease. Our work has focused on adults with type 2 diabetes, but recent studies indicate that youth who develop type 2 diabetes may have a far more aggressive course of diabetic kidney disease than their adult counterparts. Accordingly, we wish to study persons with youth onset type 2 diabetes and compare their kidney structure and transcriptomic profile with those of the adults we have already studied and to also compare them with youth onset type 1 diabetes. Therefore, we have established a collaboration with Dr. Peter Bjornstad at the University of Colorado, who is the only researcher to acquire kidney tissue in youth with youth-onset type 2 diabetes and to establish a detailed clinical phenotype in the same individuals. Dr. Bjornstad has presently conducted over 100 studies of intrarenal hemodynamic function combined with state-of-the-art functional magnetic resonance imaging in youth, including those with type 1 or type 2 diabetes. The goal of this project is for the first time to comprehensively detail morphometric, molecular, metabolic and energetic patterns of early diabetic kidney disease in youth. Tissue obtained from these biopsies will be sent to the University of Michigan where they will undergo quantitative morphometry and RNA sequencing studies performed either in single cell preparations or in the glomerular and tubulointerstitial compartments after microdissection. In this modification, we will acquire the services to obtain an additional 5 research kidney biopsies from the University of Colorado.� The morphometric and transcriptiomic work will be performed at the University of Michigan.��Data and results from these studies will be shared with NIDDK and NIDDK investigators will be authors on all publications emanating from this work. We wish to examine the underlying mechanisms responsible for the development of diabetic kidney diseasein persons with youth onset disease. We do not have access to this patient population locally, but we cancompare findings in our adult population with those from this youth onset population. By adding a second component to the study, on the same patients, makes it pertinent to use the samevendor for ensuring consistency and reproducibility of our study. Furthermore, it would be difficult tocompare the results from the first part of the study with the second part without using the same vendor.Prior work done, allows this vendor access to unique proprietary information.
- Web Link
-
SAM.gov Permalink
(https://beta.sam.gov/opp/e6966c5dbbf54734b8e936dbe39b2633/view)
- Place of Performance
- Address: Phoenix, AZ 85004, USA
- Zip Code: 85004
- Country: USA
- Zip Code: 85004
- Record
- SN05801346-F 20200919/200917230209 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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