SOURCES SOUGHT
Q -- Brain and blood bile acid concentrations in cognitive aging and Alzheimer�s disease
- Notice Date
- 7/7/2020 1:19:12 PM
- Notice Type
- Sources Sought
- NAICS
- 621511
— Medical Laboratories
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-75N95020Q00178
- Response Due
- 7/22/2020 9:00:00 AM
- Archive Date
- 08/06/2020
- Point of Contact
- Diedra Prophet, Phone: 3014028070, Karen Mahon
- E-Mail Address
-
diedra.prophet@nih.gov, karen.mahon@nih.gov
(diedra.prophet@nih.gov, karen.mahon@nih.gov)
- Description
- Description:� This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition.� It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract.� Responses will not be considered as proposals or quotes.� No award will be made as a result of this notice.� The Government will NOT be responsible for any costs incurred by the respondents to this notice.� This notice is strictly for research and information purposes only. Background:� The purpose of the overall program of research in the Laboratory of Behavioral Neuroscience (LBN) is to enhance our understanding of age-associated physical and biological changes in health and disease. The mission (objective) of the LBN is: (1) to conduct basic and clinical research on individual differences in brain structure, function and cognitive abilities; (2) to investigate the influence of age on these variables, using both cross-sectional and longitudinal designs; and (3) to identify predictors of cognitive decline and Alzheimer�s Disease, including both risk and protective factors for cognitive and brain aging. There is currently a need to identify predictive blood-based biomarkers of Alzheimer�s disease (AD). Such methods will allow for the effective screening of large numbers of vulnerable individuals for recruitment into clinical trials and rapid testing of promising disease-modifying treatments. LBN has focused on blood-based biomarkers of AD that accurately reflect well-established endophenotypes of AD pathology such as brain atrophy, and in vivo fibrillar A? deposition4-8. Using mass spectrometry-based proteomic analyses in combination with multi-modal neuroimaging, these studies have revealed a robust peripheral signal from the blood/brain proteome/metabolome that appears to be associated with AD pathology. Purpose:� To identify predictive blood-based biomarkers of Alzheimer�s disease (AD). Specifics:� Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the�Statement of Work below: Perform quantitative targeted metabolomics assays on 208 human brain, 45 rat brain and 45 rat plasma samples to measure the concentrations of Bile acids. Perform statistical analysis (accuracy, sensitivity, specificity) to identify small metabolite markers in brain that are associated with AD pathology and in serum that predict incident AD. Return all unused specimens to their place of origin. Product Information: ��QTY� � � � � DESCRIPTION� � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � 45 - Bile Acid Assay [30 ?L] /� Rat brain tissue (NIH Study 2) 45 - Bile Acid Assay [30 ?L]� /��Rat plasma/serum (NIH Study 2) 71 - Bile Acid Assay [30 ?L]� /�Human brain tissue (NIH Study 3, PM3 young) 137 - Bile Acid Assay [30 ?L]� /��Human brain tissue (NIH Study 4, PM2) 137 - Tissue Homogen. / Fecal Sample Extract. [50-100mg] /�Human brain tissue (NIH Study 4; PM2)� 137 - Data Analysis and Reporting (Quality check, data� normalization and compilation) Additional Requirements: Level of Effort: Senior researcher 960 labor hours for period of performance Government Responsibilities Provide adequate quantities of archived serum and brain tissue samples to the contractor to enable the performance of the metabolomics assays detailed above. Delivery or Deliverables Electronic copy of excel spreadsheet including absolute concentrations of all assayed metabolites in brain and blood samples to be delivered within 364 calendar says of receipt of samples by the contractor. The timely submission of this deliverable is essential to successful completing this requirement. Reporting Requirements The contractor is required to provide written progress reports every 2 months for the contract period 9/30/20 through 9/29/21. The progress report shall cover all work completed during the specified period and shall present the work to be accomplished during the subsequent period. This report shall also identify any problems that arose and a statement explaining how the problem was resolved. This report shall also identify any problems that have arisen but have not been completely resolved and provide an explanation. Anticipated period of performance: September 30, 2020 � September 29, 2021 Capability statement /information sought. Respondents must provide, as part of their responses, a capability statement including respondents�: (a) current in house capability and capacity to perform the work; (b) prior completed projects of similar nature; and (c) corporate experience and management capability; and (d) evidence that they can legally and in a timely manner, identify predictive blood-based biomarkers of Alzheimer�s disease (AD). The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2� x 11� paper size, with 1� top, bottom, left and right margins, and with single or double spacing. The information submitted must be in an outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein.� A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit.� The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents� technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses to this notice must be submitted electronically to the Contract Specialist and Contracting Officer.� Facsimile responses are NOT accepted. The response must be submitted to Diedra Prophet at e-mail address Diedra.Prophet@nih.gov and Karen Mahon at e-mail address Karen.Mahon@nih.gov. The response must be received on or before July 22, 2020 12:00 pm Eastern Time. �Disclaimer and Important Notes:� This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization�s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
- Web Link
-
SAM.gov Permalink
(https://beta.sam.gov/opp/0e49119b1020475f90d64fc5de068115/view)
- Place of Performance
- Address: Baltimore, MD 21224, USA
- Zip Code: 21224
- Country: USA
- Zip Code: 21224
- Record
- SN05713994-F 20200709/200707230155 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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