Loren Data's SAM Daily™

SAMDAILY.US - ISSUE OF APRIL 04, 2020 SAM #6701
SOURCES SOUGHT

A -- Custom Gene Synthesis Plum Island, NY

Notice Date

4/2/2020 11:11:37 AM
 

Notice Type

Sources Sought
 

NAICS

541714 — Research and Development in Biotechnology (except Nanobiotechnology)
 

Contracting Office

USDA ARS AFM APD BELTSVILLE MD 20705 USA
 

ZIP Code

20705
 

Solicitation Number

989599
 

Response Due

4/7/2020 2:00:00 PM
 

Archive Date

04/22/2020
 

Point of Contact

Sandra Daniels
 

E-Mail Address

sandra.daniels@usda.gov
(sandra.daniels@usda.gov)
 

Small Business Set-Aside

SBA Total Small Business Set-Aside (FAR 19.5)
 

Description

The FADRU has a requirement for gene synthesis to conduct molecular biology research and plasmid biorepository at Plum Island Animal Disease Center. Included in this requirement is custom gene synthesis, and gene point mutations. The proposed contract will support all gene synthesis needs. Individual requirements for gene synthesis will be submitted to the contractor. Due to the infinite potential gene synthesis involving any combination of nucleotides, individual project pricing will be based upon the agreed-upon pricing schedule along with project by project negotiation. Final project pricing will depend on the complexity of the requested gene variant. Complexity is defined and determined based on the following three factors: Secondary structure of requested variant, non-double helix DNA structures are harder to synthesize; Guanine-cytosine (GC) content of the DNA: a higher percentage of GC relative to adenine and thymine (AT) increases complexity and price; Length of new synthesis in the variant 4) Length separating requested changes when more than one area are variants.� The above three factors consider the complexity of the gene variant, and are not independent variables, but variables that when taken together in the context of a variant, increase the complexity of the gene synthesis. Other factors that can decrease price are when variants are a series that are dependent on each other, in simple terms variant 1 has mutation 1, variant 2 has mutation1+2, variant 3 has mutation 1, 2, & 3.� In this situation mutant 3 has three mutations, but only one mutation when using mutant 2 as a reference. In gene variant or mutagenesis pricing, this would constitute a group of variants, and would be discounted over a sole variant. In this case pricing will still depend on the complexity of the gene variant has defined but taking into consideration the group.
 

Web Link

SAM.gov Permalink
(https://beta.sam.gov/opp/2672988294d5489aae384fe749ca2cb1/view)
 

Place of Performance

Address: Orient, NY 11957, USA

Zip Code: 11957

Country: USA
 

Record

SN05609161-F 20200404/200402230213 (samdaily.us)
 

Source

SAM.gov Link to This Notice
(may not be valid after Archive Date)

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