SOURCES SOUGHT
Q -- DNA extraction for longitudinal studies of epigenetic changes and Alzheimer�s Disease in a population-based study
- Notice Date
- 3/23/2020 8:03:02 AM
- Notice Type
- Sources Sought
- NAICS
- 621511
— Medical Laboratories
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-20-006512
- Response Due
- 4/7/2020 11:00:00 AM
- Archive Date
- 04/22/2020
- Point of Contact
- Diedra Prophet, Phone: 3014028070, Karen Mahon
- E-Mail Address
-
diedra.prophet@nih.gov, karen.mahon@nih.gov
(diedra.prophet@nih.gov, karen.mahon@nih.gov)
- Description
- Description:� This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition.� It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract.� Responses will not be considered as proposals or quotes.� No award will be made as a result of this notice.� The Government will NOT be responsible for any costs incurred by the respondents to this notice.� This notice is strictly for research and information purposes only. Background:� Alzheimer�s disease is a devastating and global public health problem. There is an urgency to identify public health interventions and therapeutics. Recent advances in technology provide us with new opportunities to understanding the genetic contribution to disease. This project is leveraged onto an on-going effort to fully characterize the genome and related �omics� in the cohort of men and women who participated in AGES-RS. The project meets the NES overall mission to understand the dynamics of the aging process, improving the health, well-being, and independence of aging adults; and supporting the research enterprise. Specifically, NES research aims to Identify prospectively, novel risk factors and mechanisms of brain pathology and translating epidemiologic findings into experimental or clinical trial studies. Purpose and Objectives: A recent advancement towards understanding the pathobiology of AD is the identification the role of the epigenome, an intermediary between genetic and environmental interactions that can contribute to the risk of complex disease.� The epigenome modulates cell- and tissue-specific gene expression, and is also affected by nongenetic risk factors, smoking being a well-established modulator of the epigenome. Ultimately, the epigenome can change gene and protein expression, and vulnerability to disease. Integrating �omics� datasets is crucial for more complete understanding of the aging brain. In this project we will interrogate cross-sectional and longitudinal changes (AGES-RS) of methylation. Our initial research will focus on understanding the methylation changes that occur prior to and concurrent with dementia onset, whether these changes are associated with a person�s dementia risk profile, including medical history and life style behaviors. The sample to be included in this study will also have available whole genome sequencing data. Project requirements: Independently and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the Government as needed to perform the�following: Identify the sample for inclusion in the methylation sample. To the extent possible, persons in the whole genome sequencing (WGS) project should be prioritized for inclusion in this study. If the WGS does not meet the sample size target, a random sample from AGES II should be selected. The final sample should conform to a case-cohort study design whereby a random sample of the cohort is selected, that may include cases, and a purposeful sample of cases meeting case definition criteria. The effective number of cases for the analysis is the purposefully selected cases plus the random sample cases. The effective number of controls is the random sample minus cases. The DNA should be extracted from AGES II samples manually from whole blood by the salting out method. This method should be consistent with the procedure used to extract DNA from AGES I for the original genome wide association studies. Anticipated period of performance: 12 month period of performance Capability statement /information sought. Respondents must provide, as part of their responses, a capability statement including respondents�: (a) current in house capability and capacity to perform the work; (b) prior completed projects of similar nature; (c) corporate experience and management capability; and (d) evidence that they can legally and in a timely manner, select from the AGES-RS database the correct sample of participants. The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2� x 11� paper size, with 1� top, bottom, left and right margins, and with single or double spacing. The information submitted must be in an outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein.� A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit.� The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents� technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses to this notice must be submitted electronically to the Contract Specialist and Contracting Officer.� Facsimile responses are NOT accepted. The response must be submitted to Diedra Prophet at e-mail address Diedra.Prophet@nih.gov and Karen Mahon at e-mail address Karen.Mahon@nih.gov. The response must be received on or before April 7, 2020, 2:00 pm Eastern Time. �Disclaimer and Important Notes:� This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization�s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
- Web Link
-
SAM.gov Permalink
(https://beta.sam.gov/opp/5eb21132390e454ea4d0eb852e7c9cfb/view)
- Record
- SN05597928-F 20200325/200323230152 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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