SOLICITATION NOTICE
68 -- Enamine Glycomimetic Compound Library
- Notice Date
- 1/13/2020 1:04:46 PM
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 325413
— In-Vitro Diagnostic Substance Manufacturing
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIAID BETHESDA MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- RFQ-NIAID-2001907
- Response Due
- 1/22/2020 12:00:00 PM
- Archive Date
- 02/06/2020
- Point of Contact
- Skye Duffner, Phone: 4068026092, Laura Grey, Phone: 4063759812
- E-Mail Address
-
skye.duffner@nih.gov, laura.grey@nih.gov
(skye.duffner@nih.gov, laura.grey@nih.gov)
- Small Business Set-Aside
- SBA Total Small Business Set-Aside (FAR 19.5)
- Description
- This notice is a combined synopsis/solicitation for commercial items using Simplified Acquisition Procedures. This acquisition will be made in accordance with the format in Federal Acquisition Regulation (FAR) Subpart 12.6 �Streamlined Procedures for Evaluation and solicitation for commercial Items,� as applicable, and as supplemented with additional information included in this notice. This announcement constitutes the only solicitation (a written solicitation will not be issued) and quotes are being requested. The Solicitation number is RFQ-NIAID-2001907 and the solicitation is issued as a Request for Quotes (RFQ). This acquisition will be processed under FAR Part 13 Simplified Acquisition Procedures (SAP). The solicitation documents and incorporated provisions and clauses are those in effect through Federal Acquisition Circular (FAC) FAC 2020-02 and effective 12/23/2019.� The North American Industry Classification System (NAICS) code for this procurement is 325413,, IN-VITRO DIAGNOSTIC SUBSTANCE MANUFACTURING, with a small business size standard of 1250 employees. This requirement IS SET-ASIDE for small business. Background and laboratory needs: The Tuberculosis Research Section (TBS) of the Laboratory of Clinical Immunology and Microbiology (LCIM) Focuses on the development of novel chemotherapeutics and immunotherapeutics for the treatment of tuberculosis and related diseases; because much of the inherent drug resistance of Mycobacterium tuberculosis is due to their highly impermeable cell wall, important targets for new drug development lie in the enzymatic pathways responsible for cell wall biosynthesis and assembly and conducts studies to understand the pathways responsible for the synthesis and modification of mycolic acids, the major component of mycobacterial cell walls, using tools from both biochemistry and molecular genetics to foster a deeper understanding of the interactions between the various molecular components of the cell wall and create genetically engineered strains which are defective in cell wall synthesis and have utility as new improved vaccine strains; targets chemotherapeutic enzymes involved in the modification of such molecules through the construction of directed combinatorial libraries of known inhibitors of similar chemical reactions and by construction of libraries of analogs of known antituberculars. Glycomimetic are compounds that have structures similar to carbohydrates and have modified biological activities.� Our laboratory is seeking to acquire a diverse molecule library of this class of compounds to screen against M. tuberculosis to look for novel compounds with anti-tuberculosis activity. The ordered compounds need to be provided at 0.2 ul and 5mM. We need a large diversity of library compounds (>2000). Fluorescent M. tuberculosis will be incubated with these compounds and fluorescence will be read off after a few days of incubation.� We will determine the minimal inhibitory concentration with the plate reader�s data and determine if there are compounds in the library with anti-tuberculosis activity. The compounds need to be made assay ready 384-well plates. *This is a Brand-Name requirement for: QTY 1 Enamine, Glycomimetic library, 2718 compounds provided at 0.2ul at 5mM in 384-well plates *Please include your DUNS number *Include response to FAR 52.204-4 attachment and return with quote Place of Delivery: NIH/NIAID, 9000 Rockville Pike, Bldg 33, Bethesda, MD 20892 FOB: Destination Submission shall be received not later than 01/22/2020, 3:00 p.m. Eastern Standard Time The government intends to award a firm fixed price purchase order to the responsible contractor as a result of this RFQ that will include the terms and conditions set forth herein.� The award will be based on the following; price, capability to meet the requirements, delivery and the best value to the government. The following FAR provisions apply to this acquisition: 52.204-24 Representation Regarding Certain Telecommunications and Video Surveillance Services or Equipment (Aug 2019) FAR 52.212-1 Instructions to Offerors Commercial Items (Oct 2018) FAR 52.212-3 Offerors Representations and Certifications - Commercial Items (Oct 2018) Offerors must complete annual representations and certifications on-line at http://www.sam.gov/ in accordance with FAR 52.212-3 Offerors Representations and Certifications- Commercial Items (Please ensure 52.209-2 -- Prohibition on Contracting with Inverted Domestic Corporations--Representation. (Nov 2015) is updated in your SAM record) FAR 52.203-18 Prohibition on Contracting with Entities that Require Certain Internal Confidentiality Agreements � Representation (Jan 2017) The following FAR contract clauses apply to this acquisition: FAR 52-212-4 Contract Terms and Conditions Commercial Items (Oct 2018) FAR 52-212-5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders Commercial Items (Oct 2019) *The applicable subparagraphs of FAR52.212-5 are included in the attachment to this posting. FAR 52.203-19 Prohibition on Contracting with Entities that Require Certain Internal Confidentiality Agreements (Jan 2017) FAR 52.204-25 Prohibition on Contracting for Certain Telecommunications and Video Surveillance Services or Equipment (Aug 2019) FAR 52.232-40 Providing Accelerated Payments to Small Business Subcontractors (Dec 2013) FAR 52.204-19 Incorporation by Reference of Representations and Certifications (Dec 2014) HHSAR 352.222-70, Contractor Cooperation in Equal Employment Opportunity Investigations (Dec 2015) By submission of an offer, the offeror acknowledges the requirement that a prospective awardee shall be registered in the System for Award Management (SAM) database prior to award, during performance, and through final payment of any contract, basic agreement, basic ordering agreement, or blanket purchasing agreement resulting from this solicitation (www.sam.gov). Copies of the above-referenced provisions and clauses are available from http://www.acquisition.gov & http: //www.hhs.gov/regulation/index.html or, upon request, either by telephone or fax. Offers may be mailed, e-mailed or faxed to Ms. Skye Duffner, (E-Mail/ skye.duffner@nih.gov 406-802-6092). Late submissions shall be treated in accordance with the solicitation provision at FAR 52.212-1(f) (Oct 2018) All responsible sources may submit an offer that will be considered by this Agency.� Any questions or concerns regarding this solicitation should be forwarded in writing via e-mail to Ms. Skye Duffner at skye.duffner@nih.gov.
- Web Link
-
SAM.gov Permalink
(https://beta.sam.gov/opp/c0c17fbc6aa84cd0abff34dfc4e1af4c/view)
- Place of Performance
- Address: Bethesda, MD 20892, USA
- Zip Code: 20892
- Country: USA
- Zip Code: 20892
- Record
- SN05533453-F 20200115/200113230302 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's SAM Daily Index Page |