SOLICITATION NOTICE
R -- lab work and research
- Notice Date
- 11/20/2019 9:41:43 AM
- Notice Type
- Presolicitation
- NAICS
- 541690
— Other Scientific and Technical Consulting Services
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NICHD BETHESDA MD 20817 USA
- ZIP Code
- 20817
- Solicitation Number
- NICHD-20-006
- Response Due
- 12/4/2019 6:00:00 AM
- Archive Date
- 12/19/2019
- Point of Contact
- Amber Harris
- E-Mail Address
-
amber.harris@nih.gov
(amber.harris@nih.gov)
- Description
- INTRODUCTIONTHIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME).The National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Office of Acquisitions (OA) on behalf of the on behalf of the National Institute of Digestive, Diabetes & Kidney Diseases intends to award a purchase order without providing for full and open competition (Including brand-name) to EDWAN LLC for lab work and research for the NIDDK Biomedical and Metabolic Imaging Branch.NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODEThe intended procurement is classified under NAICS code 541690 with a Size Standard of $15.00.REGULATORY AUTHORITYThe resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2005-99.This acquisition is conducted under the procedures as prescribed in FAR subpart 13—Simplified Acquisition Procedures at an amount not exceeding the simplified acquisition threshold ($250,000).STATUTORY AUTHORITYThis acquisition is conducted under the authority of 41 U.S.C. 253(c) under provisions of the statutory authority of FAR Subpart 6.302- FAR 6.302-1—Only one responsible source and no other supplies or services will satisfy agency requirements 41 U.S.C. 253(c)(1). PERIOD OF PERFORMANCEOne Year upon Purchase Order AwardPlace of PerformanceNational Institutes of HealthNational Institute of Digestive, Diabetes & Kidney Diseases10 Center DriveBethesda, MD 20892 DESCRIPTION OF REQUIREMENT Instrument Patients with rare genetic mutations such as hyper immunoglobulin E (Job's) syndrome (immune system and coronary arteries), Turner's syndrome (genetics and vascular disease), lipodystrophy (metabolic dysfunction and cardiovascular disease), or HIV infection (inflammation and coronary disease), share many of the metabolic and immunological dysregulations encountered in multi-organ disease subjects inclusive of atherogenesis. T-cell dysfunction mirrors that seen in obesity affecting leptin metabolism. Finally, it is well established that such subjects acquire accelerated atherosclerosis. Therefore, a goal has been to isolate and understand the effects of these defects and the early events that signal atherosclerosis.Taking advantage of the effects of deregulation of metabolism, inflammation and immunity that play a key role in multi-organ disease progression of atherosclerosis in obesity and metabolic syndrome requires an in-depth understanding of the molecular basis of inflammatory diseases and studying their associated pro-inflammatory cytokines. Specifically, understanding the initiating pathways of the immune system, such as the Toll-Like Receptors (TLRs) and the inflammasome, to determine effective therapies involved in the dysregulation of these inflammatory signals as a treatment approach to ameliorate atherosclerosis and obesity, diabetes and hereditary autoinflammatorydiseases.Novel role for mitochondrial STAT3 has been implicated in autoinflammatory diseases with an underlying component of mitochondrial dysfunction, such as Type 2 diabetes and obesity among many other diseases. Therefore, a deeper understanding of the interplay between STAT3 and mitochondria creates a great advantage to developing therapeutic approaches to treat inflammatory diseases. Research endeavors will employ a combination of flow cytometry, cell imaging, proteomic and bioinformatic approaches to further dissect mechanisms involved in mitochondrial regulation of inflammatory diseases.The National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Biomedical and Metabolic Imaging Branch has a requirement to obtain services of a scientist with extensive expertise in innate immunology and hereditary autoinflammatory diseases with demonstrated understanding of, and ability to apply principles, concepts, practices and standards associated with patient sample testing in a laboratory setting. CLOSING STATEMENTThis synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties’ bona-fide capabilities for fulfilling the requirement and include: descriptive literature, delivery timeframe, warranties and/or other information that demonstrates that the offer meets all the foregoing requirements, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.”A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.All responses to this notice shall be submitted electronically by 9:00 am Eastern Standard Time, on Wednesday, December 4, 2019 to the Contract Specialist, Amber Harris, at amber.harris@nih.gov .Assessment of CapabilityLowest Price Technically Acceptable
- Web Link
-
SAM.gov Permalink
(https://beta.sam.gov/opp/4e33cbd7d0e5440d89f4c53a0536d7e8/view)
- Place of Performance
- Address: 7125, MD 20892, USA
- Zip Code: 20892
- Country: USA
- Zip Code: 20892
- Record
- SN05499416-F 20191122/191122043504 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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