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FBO DAILY - FEDBIZOPPS ISSUE OF JANUARY 26, 2019 FBO #6273
SPECIAL NOTICE

A -- Introduction of Point Mutation

Notice Date

1/24/2019
 

Notice Type

Synopsis
 

NAICS

541714 — Research and Development in Biotechnology (except Nanobiotechnology)
 

Contracting Office

6011 Executive Blvd 5th Floor Rockville MD 20852-3804
 

ZIP Code

20852-3804
 

Solicitation Number

NIHOLAO-OD3-NOI-5230648
 

Response Due

2/7/2019
 

Point of Contact

John Alozie, Contract Specialist, Phone 3014968413
 

E-Mail Address

john.alozie@nih.gov
 

Small Business Set-Aside

N/A
 

Description

NOTICE OF INTENT TO AWARD A SOLE SOURCE CONTRACT The National Institutes of Health (NIH) intends to negotiate a contract on a sole source basis with The Jackson Laboratory, Bar Harbor, ME. The purpose of the contract is to generate and deliver a knock-in mouse line carrying a unique point mutation in exon 5 of the Zbtb20 gene (NM_001164342) to the National Institute on Deafness and Other Communication Disorders (NIDCD). This mutation will change the G at cDNA position 2155 to an A (c.2155G>A), which will change the amino acid at position 719 of the encoded protein from valine to isoleucine. The modification will be made by CRISPR-Cas technology in C57BL/6J strain background and done in two phases. The first phase will include project design, consultation, and NIDCD approval, and generation of mutant mice by CRISPR technology, followed by genotyping to identify animals with the desired genotype. This phase is expected to take 14-16 weeks to complete. The second phase will involve breeding of appropriate founder animals to obtain N1 mice and is expected to take 14-16 weeks. In this phase, N1 animals will be genotyped to confirm those carrying the desired mutation, and founders will be shipped to the NIDCD at NIDCD's expense. NOTE: THIS NOTICE WAS NOT POSTED TO FEDBIZOPPS ON THE DATE INDICATED IN THE NOTICE ITSELF (24-JAN-2019); HOWEVER, IT DID APPEAR IN THE FEDBIZOPPS FTP FEED ON THIS DATE. PLEASE CONTACT 877-472-3779 or fbo.support@gsa.gov REGARDING THIS ISSUE.
 

Web Link

Link To Document
(https://www.fbo.gov/spg/HHS/NIH/OoA/NIHOLAO-OD3-NOI-5230648/listing.html)
 

Place of Performance

Address: Division of Intramural Research, NIDCD National Institutes of Health Porter Neuroscience Research Center 35A Convent Drive Bethesda, MD

Zip Code: 20892

Country: US
 

Record

SN05201954-F 20190126/190124230024 (fbodaily.com)
 

Source

FedBizOpps Link to This Notice
(may not be valid after Archive Date)

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