SOURCES SOUGHT
66 -- Automated Cell Culture System
- Notice Date
- 8/7/2018
- Notice Type
- Sources Sought
- NAICS
- 423490
— Other Professional Equipment and Supplies Merchant Wholesalers
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, NCATS, National Institute on Drug Abuse, National Center for Advancing Translational Science (NCATS), 6001 Executive Boulevard, Bethesda, Maryland, 20892, United States
- ZIP Code
- 20892
- Solicitation Number
- NIHDA201800430
- Archive Date
- 8/29/2018
- Point of Contact
- Jessica Adams, , Jeffrey Schmidt,
- E-Mail Address
-
jessica.adams@nih.gov, jeffrey.schmidt@nih.gov
(jessica.adams@nih.gov, jeffrey.schmidt@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Federal Business Opportunities (FBO) SOURCES SOUGHT NOTICE 1. Solicitation Number: NIHDA201800430 2. Title: Automated Cell Culture System 3. Classification Code: 66 4. NAICS Code: 423490 5. Description: This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Background: The Stem Cell Translations Laboratory (SCTL) and the 3D BioPrinting Lab within the Division of PreClinical Innovation (DPI) of the National Center for Advancing Translational Sciences (NCATS) seek to purchase a Sartorius CompacT SelecT Cell Culture System. These labs are in need of a complex automated cell culture system that will consolidate stem cell assay development, assay miniaturization applicability and adaptation to evaluate qHTS feasibility, and validation of promising new assay technologies that had previously been done piecewise by different project teams who divided project workflow between data production and these experimental evaluations. The Stem Cell group will unburden separate project teams from these tasks, while maintaining full system compatibility with the automated robotic qHTS facility, such that validated assay methods and promising assay technologies can be immediately implemented in large scale drug discovery campaigns with confidence that protocols and methods work in the high-density formats and apparatus used by the qHTS facility. This request is required for these Laboratories as part of the overall mission to develop and deploy new technology and assays for the screening of disease targets using stem cells. Given the nature of the work with a vast amount of different stem cell lines, the Stem Cell group requires some automated device that can assist in the production and maintenance of stem cell lines on an industrial scale. The TAP CompacT Cellbase System was designed to fulfill exactly that purpose. Purpose and Objectives: The National Center for Advancing Translational Sciences (NCATS) Division of Preclinical Innovation (DPI) requires one Automated Cell Culture System on a brand name or equal basis. This equipment shall be used to support novel assay development and validation screening. The SelecT automated cell culture system was developed >5 years ago, has over 40 installations world-wide, and has proven to be able to enable the production of multiple cell-lines and assay-ready plates. The SelecT system can maintain and expand adherent cells in T-175 flasks ensuring that there is no cross contamination even when many cell lines (up to 182) are cultured in parallel; the instrument can be programmed to do media exchanges and so that cells can be harvested, counted and seeded without operator intervention to help optimize screening productivity. It has the capability of plating cells in into 96, 384 and 1536-well plates, or just harvest cells for ready use. Furthermore, the instrument has the capability to measure growth rates so that it can be programmed to harvest cells at previously specified cell confluency. The instrument is also compatible with 10- layer HYPERflasks to increase cell production. Project requirements: Specifically, the NCATS DPI requires the following, or its equal: 1. One (1) TAP Biosystems CompacT SelecT APM 2. Installation of Requirement 1 at the NCATS facility For reference, the system that meets the needs of this requirement must include the following Sartorius Part Numbers,or their equal: ETO-AC-00008 Core Module ETO-AC-00008 Advanced Plating Module ETO-AC-00008 TAP Extended APM Plate Hotel (10 each) ETO-AC-00008 Compact Startup Kit ETO-AC-00008 Processing of Nunc Triple Flasks ETO-AC-00008 Processing of Corning HyperFlasks ETO-AC-00008 Low Volume Reagent Dispensing ETO-AC-00008 Email Alerts ETO-AC-00008 User Defined Flask Types ETO-AC-00008 Maintenance Spares kit N/A System delivery, installation, trainining, operator spares, service and support The Cell Culture System must meet the following requirements, or its equal: 1. The CompacT CellBase must include: Flask incubator 130 T-75 or T-175 Flasks 6-axis Anthropomorphic Robot Arm Cell Counter Pumps for 10 media lines SelPlan scheduling and capacity planning software The Advanced Plating Module must include: Processing area collection pot (600ml) Plate incubator - 140 to 280 plate capacity depending on configuration Plate Bar Code Reader Hotel Bar Code Reader SelFeeder dispenser/aspirator 6, 24, 96, 384 well plate dispensing 24, 96 insert-well plate dispensing 6, 24, 96, 384 well plate media exchange 24, 96 insert-well plate media exchange We require 10 plate hotels-can be a combination of hotel types: TAP Extended APM Plate Hotel, 1x 28-slot hotel for 96/384 well plates TAP Extended APM Plate Hotel, 1x 19-slot hotel for 6/24/insert well plates 2. CompacT Start Up Kit 3. Processing of Nunc Triple Flasks 4. Processing of Corning HYPERFlask 5. Low Volume Reagent Dispensing 6. E-mail Alerts 7. User Defined Flask Types 8. Maintenance Spares Kit Specifically, the NCATS DPI requires the following, or its equal:  One (1) TAP Biosystems CompacT SelecT SC APM  Installation of Requirement 1 at the NCATS facility The brand name or equal system must meet the following requirements, or its equal: 1. The system must be capable of culturing multiple cell lines with cell line specific protocols. 2. It must be able to operate unattended, enabling more effective use of valuable resources 3. The system must be able to culture delicate or complex cell lines such as stem cells and primary cells. 4. The system must be capable of maintaining stock cell lines for multiple projects. 5. The system must facilitate the output of cells to an external collection vessel allowing multiple flasks to be to be harvested and pooled without restricting the volume of cell suspension that can be collected 6. The system must be equipped with a cooled reagent storage system (6°C / 43°F) to enable low volume dispensing (100 - 1,000μL) for up to 6 reagents such as growth factors and transfection mixes to flasks 7. The system must have the ability to process Corning HYPERFlasks, providing a 10-fold increase in cell production capability 8. The system must be able to send system updates via email. 9. The system must automatically back up valuable information to remote media 10. The system must allow users to generate custom formatted reports 11. The system must be able to generate assay-ready plates for cell-based screening and assay development. Must be capable of processing 6, 24, 96 and 384-well standard plates and also 24 and 96-well insert plates 12. The system must be equipped with a barcode reader on the plating module to track plates during operation. 13. The system must enable direct imaging of cells in flasks, confluence measurement and enhanced QA of cells. Installation, training and delivery shall be performed by the contractor. Must include operator spares and first year Comprehensive Service and Support contract. Quantity: One (1) Anticipated period of performance: Delivery date will be nine (9) to twelve (12) months ARO Capability statement /information sought. Responses shall include a capabilities statement and the following information: • respondents' opinions about the difficulty and/or feasibility of the potential requirement or proposed acquisition, possible solutions and approaches that may currently exist in the marketplace, and information regarding innovative ideas or concepts; • information regarding respondents': (a) staff expertise, including their availability, experience, and formal and other training; (b) current in-house capability and capacity to perform the work; (c) prior completed projects of similar nature; (d) corporate experience and management capability; and (e) examples of prior completed Government contracts, references, and other related information; • general information regarding the respondent's estimate or rough order of magnitude of the effort or time that may be required for completion of the work. (NOTE: This type of information may only be requested as part of an RFI. However, care must be exercised in requesting such information. Information requested must be: (a) necessary; (b) broad in scope; and (c) used for planning purposes only. Detailed estimates must not be requested.); The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc., pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2" x 11" paper size, with 1" top, bottom, left and right margins, and with single or double spacing. The information submitted must be must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents' technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses to this notice must be submitted electronically to the Contract Specialist and Contracting Officer. Facsimile responses are NOT accepted. The response must be submitted to Jessica Adams, Contract Specialist at e-mail address jessica.adams@nih.gov. The response must be received on or before August 14, 2018, 1:00pm, Eastern Time. Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)."
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/notices/00121b27a5f4da63a061dff5993ca16a)
- Place of Performance
- Address: National Center for the Advancement of Translational Sciences, 9800 Medical Center Drive, Bldg. C, Rockville, Maryland, 20850, United States
- Zip Code: 20850
- Zip Code: 20850
- Record
- SN05024047-W 20180809/180807231235-00121b27a5f4da63a061dff5993ca16a (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |