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FBO DAILY - FEDBIZOPPS ISSUE OF AUGUST 01, 2018 FBO #6095
SOURCES SOUGHT

R -- Computational Analysis of the Membrane Protein BetP using Molecular Simulation and Structural Refinement - Statement of Work - Technical Evaluation Criteria

Notice Date

7/30/2018
 

Notice Type

Sources Sought
 

NAICS

541715 — Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
 

Contracting Office

Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211, MSC 9559, Bethesda, Maryland, 20892-9559, United States
 

ZIP Code

20892-9559
 

Solicitation Number

NIHDA201800395
 

Archive Date

8/22/2018
 

Point of Contact

Stephanie D. Dewitt, Phone: 3014432848
 

E-Mail Address

stephanie.dewitt@nih.gov
(stephanie.dewitt@nih.gov)
 

Small Business Set-Aside

N/A
 

Description

Technical Evaluation Criteria Statement of Work The research program of the Computational Structural Biology Unit, (NINDS/NIH) aims to advance our understanding of the functional mechanisms of membrane proteins related to neuronal transporter proteins, in part through computer-simulation approaches. This research requires a significant, sustained effort to carry out and interrogate the results of molecular simulations for transporters so as to examine the structural dynamics of these molecular systems. Studies over the past 8 years in the Computational Structural Biology Unit have so far resulted in Terabytes of simulation data for BetP in a wide range of conditions that hold within them a wealth of untapped information. The specific aims of this project are: (a) to carry out a systematic analysis of the available molecular simulation data for BetP and thereby to identify common or unusual dynamics of the protein and its interplay with its environment, as well as regions of the protein for which the underlying structural data is ambiguous; (b) to interrogate the underlying structural data in the light of those simulations and carry out refinement of structural models using that data; and finally (c) to utilize the newly-refined structures as starting points for additional molecular simulations, and to carry out additional analysis of those simulations. Novel findings will be written and published as articles in a scientific journal. The aims and deliverables of this project therefore require an individual with world-class experience not only in carrying out and analyzing molecular simulations, but also in the refinement of structural models using X-ray crystallographic and cryo-EM data using the software PHENIX and COOT. In addition, the contractor must have a detailed knowledge of the biological context of the project, namely the properties of BetP and the interplay of its function and regulation with the lipid molecules in its membrane environment, as demonstrated by authorship on published work in the biomedical literature. See Statement of Work for more details.
 

Web Link

FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-01/NIHDA201800395/listing.html)
 

Place of Performance

Address: 35 Convent Drive, Building 35A, Room GF123, Bethesda, Maryland, 20892, United States

Zip Code: 20892
 

Record

SN05012582-W 20180801/180730230811-0c842cff1831a0960b65b5af4a37dce0 (fbodaily.com)
 

Source

FedBizOpps Link to This Notice
(may not be valid after Archive Date)

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