SOURCES SOUGHT
66 -- Mass Spectrometer for the expansion of mass spectrometry capabilities at NCATS
- Notice Date
- 5/1/2018
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211, MSC 9559, Bethesda, Maryland, 20892-9559, United States
- ZIP Code
- 20892-9559
- Solicitation Number
- NIHDA201800191
- Archive Date
- 5/26/2018
- Point of Contact
- Hunter A Tjugum, Phone: 3018275304
- E-Mail Address
-
hunter.tjugum@nih.gov
(hunter.tjugum@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- INTRODUCTION This is a "Sources Sought" notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. The information requested will assist the Government in determining the appropriate acquisition method, including whether a small business social-economic set-aside, competitive or non-competitive method is possible, and to determine the availability of all qualified companies technically capable of meeting the Government's requirement. NORTH AMERICAN CLASSIFICATION SYSTEM (NAICS) CODE The NAICS code applicable to this requirement is 334516 Analytical Laboratory Instrument Manufacturing with size standard 1000 employees. Background: The National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) was officially established in fiscal year 2012 to transform the translational science process so that new treatments and cures for disease can be delivered to patients faster. NCATS, one of 27 Institutes and Centers (ICs) at NIH, strives to develop innovations to reduce, remove or bypass costly and time-consuming bottlenecks in the translational research pipeline in an effort to speed the delivery of new drugs, diagnostics and medical devices to patients. Through collaborations with industry, academia, patient advocacy and other nonprofit groups and in cooperation with other NIH ICs and government agencies, NCATS provides: Pre-clinical drug development expertise and access to resources; assistance generating data needed for regulatory approval; and a variety of mechanisms to streamline partnerships and collaborations. NCATS collaborates with investigators to study and develop compounds and molecules to further translational research. Purpose and Objectives This Sources Sought notice seeks to determine eligible sources capable of achieving the essential features of this potential requirement in accordance with the specifications described in this notice. The Division of Preclinical Innovation (DPI) within NCATS strives to create and test innovative methods to improve and accelerate the drug development process and find new treatments for patients faster. DPI discovers new uses for approved drugs to provide the quickest possible transition from bench to bedside through early- and late- stage Drug repurposing. DPI develops better model systems for drug and toxicity testing and identifies and rigorously validates the molecular targets underlying disease progression. Using state-of-the-art resources to enable the ongoing operation of all NCATS translational research activities, DPI's cross-cutting core technologies enable the ongoing operation of all the Center's research activities in the fields of automation, compound management, analytical chemistry and informatics, among others. DPI has a potential requirement for a Mass Spectrometer to accommodate the expanding scientific needs of numerous programs within NCATS. In addition to enhancing existing mass spectrometry experimental capabilities, a state-of-the-art mass spectrometer will enable analysis techniques not currently available within the Center. Mass Spectrometry is an extremely powerful analytical tool that chemists and biologists use in the identification and quantitation of various chemical entities ranging in size from small molecules to antibodies. Access to a next generation MS instrument that possesses the highest level of experimental capabilities is imperative to propel DPI research forward in the successful pursuit of the NCATS mission. Project Requirements Contractors submitting a response to this Sources Sought notice shall possess the ability to achieve the essential government features specified in this notice. Offerors to this Sources Sought notice shall document evidence of being able to provide the subject requirement in accordance with the following salient characteristics of the subject potential requirement: Combines quadrupole, linear ion trap, and mass analyzers and features CID, HCD, ETD and EThcD fragmentation techniques, available at any stage of MSn analysis, with subsequent mass analysis in either ion trap or mass analyzer. Inlet source housing with x- and y-direction probe positioning and a fixed on-axis view port. All gas and voltage connections hard connected automatically, generating fluoranthene anions for electron transfer dissociation (ETD) and the internal calibrant ions for real-time mass calibration of any spectrum. Independent dual barrel syringe pump and injector/divert valve with mounting bracket controlled via the data station for maximum flexibility. Vacuum system containing a split-flow turbomolecular pump, which controls the vacuum in multiple regions for improved vacuuming resulting in improved ion transfer to the mass analyzer High capacity transfer tube and an electrodynamic ion funnel to capture and efficiently focus ions in a tight beam with active beam guide to reduce noise by preventing neutrals and high-velocity clusters from entering the mass filter. Segmented quadrupole mass filter consisting of segmented 4mm field radius quadrupole mass analyzer with a hyperbolic surface providing excellent peak shape and transmission with a minimum resolution. Mass Analyzer with an m/z range of 50-6000, resolving power of up to 500,000 FWHM and isotopic fidelity of up to 240,000 FWHM at m/z 200. Dual-pressure linear ion trap used for MSn precursor ion isolation, collision-induced dissociation (CID) and electron-transfer dissociation (ETD) with ions detected at maximum scan rate of 20 Hz using dual-dynode detector with high linear dynamic range for improved quantitation and a large surface area for increased lifespan and robustness. Independent dual barrel syringe pump and injector/divert valve with mounting bracket, which are both controlled via the data station for maximum flexibility. A Computer System and Processor with Memory, Graphics Monitor, Video, Hard Drive, DVD, Keyboard, Mouse and Operating System with software licenses and Computer Configuration shall be included and specified by Offeror. System accessories, installation and any application performance testing by trained field service engineers to assure components and system are functioning properly and that the installation specifications are met. Covered by the manufacturers basic warranty in accordance with standard commercial warranty practice, including inside delivery after receipt of an order and installation and training. Delivery: Offerors should indicate an estimated delivery time in full after receipt of an order and any other training or factory warranty schedules in accordance with standard commercial practice, as applicable. Inspection and acceptance will be performed at a Government facililty located at 9800 Medical Center Drive, Rockville, MD 20850. Capability statements sought Interested parties are expected to review this notice to familiarize itself with the requirements of this product or service. Failure to do so will be at your firm's own risk. Respondents must provide, as part of their response: (a) product, catalog, model, and/or part number(s); (b) product description; (c) best estimated delivery date after receipt of order; (d) all relevant information and documentation that the item(s) offered meets the salient physical, functional, or performance characteristics as specified in this announcement. Respondents that believe that they are authorized resellers of the equipment described in this announcement may provide, in addition to the aforementioned information, as part of their response: quantity; estimated price or cost; shipping, handling, and/or installation charges. The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc.) pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2" x 11" paper size, with 1" top, bottom, left and right margins, and with single or double spacing. The response is limited to fifteen (15) pages. The 15-page limit does not include the cover page, executive summary, or references, if requested. The information submitted must be in an outline format that addresses each of the elements of the product requirement. A cover page and an executive summary may be included but is not required. The response must include the respondents' technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. Respondents must reference the announcement number NIHDA201800191 on all correspondence related to this Sources Sought notice. The response must be submitted to Mr. Tjugum electronically, at hunter.tjugum@nih.gov and be received prior to the closing date specified in this announcement. CONCLUDING STATEMENTS Disclaimer and Important Notes. This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-01/NIHDA201800191/listing.html)
- Record
- SN04906159-W 20180503/180501230714-dcc2267469be66939d1aec209ceb968c (fbodaily.com)
- Source
-
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