SOURCES SOUGHT
66 -- Lab Equipment
- Notice Date
- 8/1/2017
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 6001 Executive Boulevard, Room 3165, Bethesda, Maryland, 20892, United States
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-SBSS-2017-631
- Archive Date
- 8/26/2017
- Point of Contact
- Andrea McGee, Phone: 301480-2449
- E-Mail Address
-
amcgee@nida.nih.gov
(amcgee@nida.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- 1.Solicitation Number: HHS-NIH-NIDA-SSSA-SBSS-2017-631 2.Title: Lab Equipment 3.NAICS Code: 334516 4.Description: Multimode Microplate Reader (brand name or equal) This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Background: The NIDA program requires a Multimode Microplate Reader Purpose and Objectives: The purpose of this acquisition is to build a throughput drug screening system uniquely customized for the lines of research in receptor pharmacology and drug discovery conducted in the Computational Chemistry and Molecular Biophysics Unit. Using a resonance energy transfer principle, molecular proximity between proteins of interest such as dopamine receptors and their signaling effectors will be detected to determine potencies and efficacies of particular chemical ligands. With the sole source features described below, the requested plate reader will be a central piece for the experimental side of our work as it will be used for drug screening as well as elucidation of molecular mechanisms behind pharmacology of key receptor targets in drug abuse. In addition, this set-up will be used as shared equipment within the Molecular Targets and Medications Discovery Branch as it has relevant applications in their lines of research (e.g. fluorescence and luminescence quantitative analysis). Features/Requirements: Multiple Measurement Principles Needed: -Fluorescence Intensity, Fluorescence Polarization (FP), Luminescence, Fluorescence Resonance Energy Transfer(FRET) and Bioluminescence resonance energy transfer (BRET). -Able to be upgraded to include: Time-Resolved Fluorescence, HTRF® or Time-Resolved fluorescence resonance energy transfer (TR-FRET), and optional Laser-based AlphaScreen® / AlphaLISA®/AlphaPlex®. Simultaneous Dual Emission Detection in all measurement modes -Both emission wavelengths are collected at the same time from top or bottom of plate. Greatly enhances speed, throughput, and accuracy - especially for FRET, TR-FRET, BRET, FP, and AlphaPlex assays. -Four PMTs optimized and matched for various measurement modes -PMTs are automatically selected when needed with no user intervention -Unique - No other reader has this ability in all detection modes from the top and bottom Multiple Excitation Sources: -Standard high intensity Xenon flashlamp for excitation -Optional AlphaScreen solid state red laser -Optional pulsed nitrogen UV laser at 337nm for TRF and TR-FRET such as HTRF (lanthanide based), LanthaScreen and DELFIA Optional Ultra-Fast UV/Vis spectrometer that allows for full-spectrum absorbance measurement to be taken in less than 1 second per well at 1,2,5 and 10nm resolution. Direct Optic Bottom Reading - Unmatched bottom reading for cell-based assays is achieved through innovative engineering using a series of software controlled lenses and mirrors while allowing for automatic software controlled switching between top and bottom reading. No liquid light guides like other instruments. Assay modules with ALL filters and dichroics contained in one component - no swapping of filters, wheels, dichroics, mirrors, or other pieces necessary -Uses same filters/dichroic for top and bottom read - no physical movement Optional on-board integrated reagent injectors for assays that acquire the ability to monitor a signal before, during, and after the addition of a reagent to a well. Fast read times for FI, FRET, and FP - 14s for a 384 well plate, and 27s for a 1536 well plate (1flash) Accurate Z height focus - 100-micron resolution for fantastic sensitivity Reads 6-3456 well plates - user definable plate formats -Measuring 3456-well plates in all modes is a unique feature to the PHERAstar. Easily interfaced with robotic systems through DDE or ActiveX interface License-free Software included at no cost, can be used on as many machines as you like, no licensing arrangements FDA 21 CFR Part 11 Software Compliance included at no additional charge Includes Training and Installation Anticipated period of performance: 6 weeks after receipt of order Capability statement /information sought. Contractors that believe they possess the ability to provide the requirement should submit documentation of their ability to meet each of the project requirements to the Contract Specialist. The response should directly and specifically state in the, capabilities statement, which project requirements you can supply. Contractors must also provide their Company Name, DUNS Number, Physical Address, Point of Contact, and Size and Type of Business (e.g., 8(a), HubZone, etc.) pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2" x 11" paper size, with 1" top, bottom, left and right margins, and with single or double spacing. The information submitted must be must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents' technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses (capability statements) sent in response to this Small Business Sources Sought Notice must be submitted electronically (via e-mail) to the Contract Specialist. Facsimile responses are NOT accepted. The response must be submitted to Andrea McGee, Contract Specialist at e-mail address amcgee@mail.nih.gov The response must be received on or before August 11, 2017 at 12:00PM, eastern time. "Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)."
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-2/HHS-NIH-NIDA-SSSA-SBSS-2017-631/listing.html)
- Place of Performance
- Address: 333 Cassell Drive, Baltimore, Maryland, 21224, United States
- Zip Code: 21224
- Zip Code: 21224
- Record
- SN04607309-W 20170803/170801232524-884da334e82dd8e93fa13ad14b57961f (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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