SOLICITATION NOTICE
B -- Metabolomic Analysis of Serum Proteins
- Notice Date
- 8/26/2016
- Notice Type
- Presolicitation
- NAICS
- 611430
— Professional and Management Development Training
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- HHS-NIH-NHLBI-CSB-(HG)-2016-293-DM
- Archive Date
- 9/16/2016
- Point of Contact
- Dorothy Maxwell, Phone: 301-435-0352
- E-Mail Address
-
maxwelld@mail.nih.gov
(maxwelld@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- INTRODUCTION: THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR A PROPOSAL. A SOLICITATION DOCUMENT WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. The National Institutes of Health, National Heart, Lung, and Blood Institute (NHLBI) Office of Acquisition (OA) the National Human Genome Research Institute (NHGRI), intends to negotiate and award a purchase order on a non-competitive sole source basis to the University of California, Davis, 1850 Research Park Drive, Suite 300, Davis, California 95618-6134 to provide the following: Procurement: 1. Plasma: Data acquisition for primary metabolites: • by GCTOF MS (600 + 60 QC) plasma, Quantity Six Hundred Sixty (660); • Sample preparation, primary data processing for GC-TOF MS, Quantity: 185 hours; • Labor rate 2, Data curation, reporting, Quantity: 53 Hours; 2. Plasma: Data acquisition for complex lipids: • by CSH-QTOF MS (600 + 60 QC), Quantity Six Hundred Sixty (660); • Labor rate 1: Sample preparation, primary data processing for LC-QTOF MS by MS-DIAL and LipidBlast, Quantity: 185 Hours; • Labor rate 2, data curation, reporting; Quantity: 53 Hours; 3. Urine: Data acquisition for primary metabolites: • by GCTOF MS (600 + 60 QC) Urine, Quantity Six Hundred Sixty (660); • Labor rate 1, sample preparation, primary data processing, Quantity: 185 Hours; and • Labor rate 2, data curation, reporting, Quantity: 53 Hours. Background: The National Institute of Health (NIH) mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. The National Human Genome Research Institute (NHGRI), mission has expanded to encompass a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. NHGRI supports the development of resources and technology that will accelerate genome research and its application to human health. A critical part of the NHGRI mission continues to be the study of the ethical, legal and social implications (ELSI) of genome research. NHGRI also supports the training of investigators and the dissemination of genome information to the public and to health professionals. The National Human Genome Research Institute (NHGRI), The NHGRI/DIR Cardiovascular Disease Section (CDS) and the NHGRI/DIR Social Epidemiology Research Unit conducts a broad program of clinical and translational research seeking a greater understanding of the genomic basis of human cardiovascular disease. A major component of the research centers understands epigenetic modifications contributing to cardiovascular disease phenotypes such as resistant hypertension and coronary calcification. The NHGRI/DIR Cardiovascular Disease Section (CDS), Dr. Gibbons Laboratory conducts a broad program of clinical and translational research seeking a greater understanding of the genomic basis of human cardiovascular disease. A major component of Dr. Gibbons Laboratory clinical research centers on understanding transcriptome modifications contributing to cardiovascular disease phenotypes. CDS requires the services of a vendor providing the capability for assaying proteins and other analytes from small amounts of urine and plasma isolated from human samples. The goals of CDS include identifying changes in protein abundance and activity that contribute to cardiovascular disease endpoints such as resistant hypertension. UC Davis supports the goals of the CDS. Purpose and Objectives: The objective of this clinical research study is to take an integrative systems biology approach to define functional pathways that link ancestry-related DNA variation and the metabolome. The metabolomics analysis will measure proteins and molecules in the plasma and urine of samples across the CVDS studies to understand the differences between controls and disease states. A major component of our research centers on understanding metabolite changes contributing to cardiovascular disease phenotypes such as resistant hypertension and coronary calcification. UC Davis Genome Center will accept samples at the available urine volume (1ml) and treated with Norgen preservative, this is a project at a large scale with analogous samples. a. Proteins and there chemical interactions are important class of biological molecules which perform crucial functions in gene regulation and intracellular signaling for metabolomic homeostasis through mechanisms such as protein and phosphorylation, cleaving and binding to DNA, RNA and between proteins. Recently, it has become possible to profile the comprehensive set of metabolites through two proprietary methods Primary Metabolism and Complex Lipid designed by UC Davis, West Coast Metabolomics Center: 1. Primary metabolism profiling by gas chromatography /time of flight mass spectrometry. There are approximately 200 metabolites that can be identified in addition to 200-300 compounds of unknown chemical structure. 2. A complex lipid analysis utilizing ultra-high pressure liquid chromatography (UHPLC) on a Waters CSH column, interfaced to a QTOF mass spectrometer. These data are collected in both positive and negative ion mode, and analyzed using MassHunter (Agilent). Approximately 400 lipids can be identified from plasma, with additional unknowns. The method is highly stable and has been validated on large datasets (>8,000 samples) collected over long time periods (> 1 year). b. The Gibbons lab is currently archiving in the cryorepository human urine and serum samples from cases and controls for cardiovascular disease phenotypes. Combining points (a) and (b) above, Dr. Gibbons Laboratory and research investigators intend to investigate metabolomic changes associated with this phenotypes in urine and serum utilizing the two methods in 1 and 2 above. Regulatory Authority: The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2005-89-1, August 15, 2016. This acquisition is conducted under the authority of the Federal Acquisition Regulations (FAR) Subpart 13 Simplified Acquisition Procedures (SAP). Statutory Authority : This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures, Subpart 13.106-1(b)(1), Soliciting from a single source is not expected to exceed the simplified acquisition threshold. Contracts awarded using FAR Part 13--Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6-Competition Requirements. Closing Statement : The acquisition is being conducted under FAR Part 13, simplified acquisition procedures, therefore the requirements of FAR Part 6 B Competitive Requirements are not applicable (FAR Part 6.001. Industry Classification (NAICS) Code is 611430, Professional and Management Development Training and the small business size standard number is $11.0M. This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received no later than 7:30 a.m. Eastern Standard Time (EST), September 1, 2016; and must reference synopsis number HHS-NIH-NHLBI-CSB-(HG)-2016-293-DM, may be submitted to the National, Heart, Lung and Blood Institute, COAC Services Branch, Office of Acquisitions, Office of Management, 6701 Rockledge Drive, Suite 6149, Bethesda, Maryland 20892-7902, Attention: Dorothy Maxwell, Contracting Officer. Response may be submitted electronically to maxwelld@mail.nih.gov. Faxes will not be accepted. Responses will only be accepted if dated and signed by an authorized company representative. "All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency."
- Web Link
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FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/HHS-NIH-NHLBI-CSB-(HG)-2016-293-DM/listing.html)
- Place of Performance
- Address: NIH and Contractor's Location, United States
- Record
- SN04243375-W 20160828/160826235121-173fd89df15493596c87c22fef133d33 (fbodaily.com)
- Source
-
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