SOURCES SOUGHT
66 -- Parr Bench Top Reactor System
- Notice Date
- 7/6/2016
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 3155, MSC 9593, Bethesda, Maryland, 20892, United States
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-SBSS-2016-411
- Archive Date
- 8/7/2016
- Point of Contact
- Stacey M Polk,
- E-Mail Address
-
spolk@nida.nih.gov
(spolk@nida.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Background: The purpose of the NIH Therapeutics for Rare and Neglected Disease program (TRND) is to develop new candidate drugs for individuals with rare and neglected diseases. TRND activities will build upon the NIH Roadmap to accomplish its goals including the successes of NCATS. Our group facilitates drug discovery from the basic research lab to the pre-clinical stage. Picking up where our Probe Development Group work leaves off, TRND will concentrate its efforts on the pre-clinical stage of drug development, where researchers develop clinical candidate in preparation for human testing. In doing so, TRND will help bridge the wide gaps in time and resources that often exist between basic research and clinical testing of new drugs. It is expected that in most cases, TRND's clinical candidates will be licensed to biopharmaceutical companies for further development, thus allowing TRND to focus on the scientifically challenging pre-clinical stages of the drug development, and "de-risking" the projects sufficiently to make them adoptable by private sector companies. Synthetic organic chemistry can be broken down into three main processes. First - the combination of chemical reagents in a fashion that predictive reactions occur and novel chemical matter is created. These reactions are done in step-wise fashion ultimately producing compounds of biochemical interest and use. The second aspect of synthetic chemistry is the purification of the products you want. This is an essential component, as unwanted byproducts poison reactions and complicate biological appreciation. The third aspect is the characterization of these constructs to assure that a scientist has made what he/she predicted would be made. Each of these steps requires its own unique infrastructure, equipment and skills. Purpose and Objectives: The mission for the chemistry team is the optimization chemistry on "clinical candidates". The chemistry team must be capable of the fast and efficient synthesis and purification of small molecules. Project requirements: The following brand name items are required: Brand Name: Parr 1. 4563-T-M(HC)-HC-VS.12-3000-115-4848-no cooling-2 extra valves; Series 4560 Bench Top Reactor System: 600 mL vessel with removable head and cylinder constructed of Alloy C-276. Magnetic drive and internal wetted parts (in direct contact w/ the liquid process) constructed of Alloy C-276. External valves and fittings constructed of T316 SS* With the following specifications: A) MAWP Rating: 3000 psi at up to maximum temperature of 350°C B) PTFE Flat Gasket and Split Ring Closure C) Head to Include: 1) Magnetic Drive, 16 in-lbs torque, Alloy C-276 with stir shaft and turbine impeller 2) Rupture Disc of Alloy C-276, rated to 3000 psi 3) Pressure Gage, 0-3000 psi and Gas Release Valve 4) Double Valve Assembly with Liquid Sampling and Gas Inlet Valves over Dip Tube 5) With Thermowell and J-Type Thermocouple 6) Use cooling ports to add 2 additional needle valves for gas inlet connections D) Cylinder, 600 mL with ID of 2.5" and IL of 8.0" E) Mantle Heater 115V, 780W, Quick connect F) Variable speed motor, 1/8 hp G) 4848 Reactor Controller with the following specifications: 1) PID, temperature programmability with ramp and soak 2) Manual speed adjustment knob, 0-600 rpm 2. 4561-conversion parts in Alloy C-276 for a 4563 Alloy C-276 vessel assembly with the following specifications: A) 452HCCH 300 mL cylinder, Alloy C-276 B) A2230HC18EB, 300 mL quick connect mantle heater, 115 V, 510W C) A1453HCCH, thermowell D) 217VBCH, TW connection nut E) 218VBCH, TW connection ferrule set F) 832HC4CH, dip tube G) 822HC15CH, shaft H) No cooling loop I) Use impeller from other reactor J) Support bracket on standard mag drive not required for 300 mL volume K) Use head from other reactor L) Assembly required Anticipated period of performance: Delivery within three weeks ARO Capability statement /information sought. Contractors that believe they possess the ability to provide the requirement should submit documentation of their ability to meet each of the project requirements to the Contract Specialist. The response should directly and specifically state in the, capabilities statement, which project requirements you can supply. Contractors must also provide their Company Name, DUNS Number, Physical Address, Point of Contact, and Size and Type of Business (e.g., 8(a), HubZone, etc.) pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. The information submitted must be in an outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. The response must include the respondents' technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses (capability statements) sent in response to this Sources Sought Notice must be submitted electronically (via e-mail) to the Contract Specialist. Facsimile responses are NOT accepted. The response must be received on or before the notice response due date. Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)."
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-01/HHS-NIH-NIDA-SSSA-SBSS-2016-411/listing.html)
- Place of Performance
- Address: National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland, 20850, United States
- Zip Code: 20850
- Zip Code: 20850
- Record
- SN04172899-W 20160708/160706235158-746e66cb30f2e91ed807d5860a89d13c (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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