SPECIAL NOTICE
R -- Data Analysis Tools
- Notice Date
- 3/14/2016
- Notice Type
- Special Notice
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Commerce, National Institute of Standards and Technology (NIST), Acquisition Management Division, 100 Bureau Drive, Building 301, Room B130, Gaithersburg, Maryland, 20899-1410, United States
- ZIP Code
- 20899-1410
- Solicitation Number
- MOD14SE0401
- Archive Date
- 4/8/2016
- Point of Contact
- Carol A. Wood, Phone: 301-975-8172, Carol A. Wood, Phone: 301-975-8172
- E-Mail Address
-
carol.wood@nist.gov, carol.wood@nist.gov
(carol.wood@nist.gov, carol.wood@nist.gov)
- Small Business Set-Aside
- N/A
- Description
- The Office of Acquisition and Agreements Management (OAAM), Acquisition Management Division (AMD) of the National Institute of Standards and Technology (NIST), on behalf of the Material Measurement Laboratory (MML), Chemical Sciences Division (CSD), intends to negotiate on a sole source basis with Leonard Industries Robotics Engineering and Design, of Alexandria, VA, for a modification to an existing contract. In September of 2014, NIST/AMD competitively awarded contract number SB1341-14-SE-0401 to Leonard Industrial Robotics Engineering and Design (LIRED) to implement computer codes to provide the necessary computational infrastructure to generate efficient data analytics tools for the integrated processing of mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy data for metabolomics and petroleomics as applied to health and environment. The contract was for a one-year base period with one one-year option period. Work under the base period addressed metabolomics. Work under the option period addressed petroleomics. Option period I was exercised in September of 2015. The contract required the government to supply the contractor with a sufficiently large and robust collection of quality metabolomics and petroleomics data to develop and test the new analytic tools and to serve as the body of data to be analyzed. NIST has been unable to establish sufficient connections to internal and external sources of quality petroleomics data to meet this requirement. Thus, the government determined, after the option period had been exercised, that it could not complete its obligations with respect to the development of petroleomics tools and analysis with LIRED as required for the option period. Concurrently, the government's mission priorities and objectives determined that lipidomics would be the direction of wisest progression in the development of integrated measurements and data across multiple "omics" disciplines based on available data, tractability and relevance. The analysis algorithm and workflow established by LIRED for metabolomics was determined to be the basis upon which to build the same analysis capability in lipidomics. This approach is consistent with the Government's project timelines for inter-laboratory comparisons of lipidomics using developed tools. The Government intends to modify the scope of the contract to change the requirement such that LIRED shall generate efficient data analytic tools for the integrated of mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy data for lipidomics, in lieu of petroleomics. It is required that LIRED complete the required work for lipidomics. This determination is based upon the following: The MML/CSD is presently launching an FY16 inter-laboratory comparison of candidate materials with national and international stakeholders in metabolomics and lipidomics. The development of appropriate and consistent data analytics tools and associated metrics is critical to the quality assessment of inter-laboratory data that will distinguish among different samples, processing conditions and laboratories. Community access to these Reference Materials and Data (RMDs) and the developed data analytics tools are critical to provide convergence of the capability needed for measurement harmonization of the emerging fields of metabolomics and lipidomics. NIST's need to develop unique data analytics tools for the analysis of raw and processed spectral lipidomics data, and to support the processing and analysis of this data using the developed tools is required to be completed by the end of fiscal year 2016. The contractor must provide both scientific software development and experienced data processing and analysis of MS and NMR data. The contract requires the development of specialized data analysis tools within 60 days of contract award. Processing and analysis of MS and NMR data, plus refinements to data analysis tools and workflow, are required throughout the contract period. The resulting computational infrastructure must be compatible with existing metabolomics data analysis algorithms and workflows to facilitate a comprehensive suite of Reference Materials and Data across these two areas of research. In addition to the work conducted with LIRED on metabolomics in FY15, CSD has already invested the full time efforts of a guest researcher and 1.5 full-time employees into developing complementary data analytics tools for the analysis of raw and processed spectral metabolomics and lipidomics inter-laboratory comparison data. The government's ultimate RMD will consist of multiple data analysis tools and workflows derived from internal and external sources, with the tools and analysis being but a part of the whole. LIRED developed data analysis tools and workflows for metabolomics is the first of this intended suite of "omics" analysis tools. The success of the metabolomics effort is the result of one year of effort. The majority of the software development was at the beginning of the contract period, and experienced processing and analysis of NMR and MS data along with workflow refinements were provided throughout the contract period. The same methodology must be utilized for the development of lipidomics data analytic tools so that the resulting RMD suites share a common basis across multiple "omics". While NIST maintains data rights under the contract, the requirement for the resulting RMD suites to share a common basis across multiple "omics" extends beyond providing another Contractor with deliverables produced under the existing contract. The primary beneficiaries of these RMDs in the biochemistry community are clinical researchers, healthcare diagnostic test providers, industry, and federal laboratories that assist public health (NIH, CDC, FDA). Consistent methodologies reduce training and familiarization barriers to acceptance and application in the different areas of research, promoting the wide use of reliable modeling tools that integrate measurements and quality data to advance both knowledge and technology. Differing methodologies must be vetted by the government for quality of the scientific information generated from the corresponding data analysis at the cost of months of effort with an uncertain end. A fragmented analysis suite would seriously limit the impact of the project due to the required additional burdens on the intended customer of training and familiarization when different datasets are involved. These burdens directly conflict with the requirement to develop a common, consistent set of tools and data that enables this community to ultimately perform true and reproducible "omics" measurements. Considering the requirement for data analytics tools to be completed in Fiscal Year 2016, the need to maintain a common and consistent set of tools and data to provide to the user community, and based upon the information herein, incorporating a change from petroleomics to lipidomics into the contract with LIRED, represents the most advantageous method of fulfilling the Government's needs. This notice of intent is not a request for competitive quotations; however, responses received by March 24, 2016, will be considered by the Government. A determination by the Government not to proceed with the proposed modification, based upon responses to this notice, is solely within the discretion of the Government. Information received will normally be considered solely for the purpose of determining whether to re-compete this requirement.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/DOC/NIST/AcAsD/MOD14SE0401/listing.html)
- Place of Performance
- Address: NIST, 100 Bureau Drive, Gaithersburg, Maryland, 20899, United States
- Zip Code: 20899
- Zip Code: 20899
- Record
- SN04048968-W 20160316/160314234346-96d8b2f344ccf106d41656dd43e13149 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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