SOURCES SOUGHT
68 -- GeneArt® Lentiviral CIRSPR Arrayed Kinase Library and GeneArt® Lentiviral Arrayed Cas9 Library
- Notice Date
- 9/1/2015
- Notice Type
- Sources Sought
- NAICS
- 325414
— Biological Product (except Diagnostic) Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211 - MSC 9559, Bethesda, Maryland, 20892, United States
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-SBSS-2015-820
- Archive Date
- 9/23/2015
- Point of Contact
- Samantha A. Kelly, Phone: 3014028855
- E-Mail Address
-
samantha.kelly2@nih.gov
(samantha.kelly2@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- SOURCES SOUGHT NOTICE 1.Solicitation Number:HHS-NIH-NIDA-SSSA-SBSS-2015-820 2.Title: GeneArt® Lentiviral CIRSPR Arrayed Kinase Library and GeneArt® Lentiviral Arrayed Cas9 Library 3.NAICS Code: 325414- Biological Product Manufacturing 4.Description: This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Background: The National Center for Advancing Translational Sciences (NCATS) is a part of the National Institutes of Health (NIH), which mission it is to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions. CRISPR-based reagents are used for the gene specific knockout of genes in cells. They are needed to facilitate our RNAi screening program. This program is conducting genome-wide siRNA screens in collaboration with NIH intramural investigators. This work includes RNAi assay development, screening, and initial follow up. As such, discovering probe molecules that could serve as starting points for therapeutics in rare cancers is of great interest within NCATS. NCATS has several projects that address many aspects of oncology mechanisms and approaches to discovering novel, effective small molecules. Therefore, the NCATS is in need of a CRISPR collection that will be used to establish a screening system without the use of lentiviral vectors or plasmids to corroborate and complement siRNA screen data. Purpose and Objectives: The purpose of this requirement is to procure the GeneArt® Lentiviral CRISPR Arrayed Kinase Library and GeneArt® Lentiviral Arrayed Cas9 Library on a brand name or equal basis. Features/Requirements: The GeneArt® Lentiviral CIRSPR Arrayed Kinase Library (or brand name equal) and GeneArt® Lentiviral Arrayed Cas9 Library (or brand name equal) will be used to confirm active gene hits identified from primary siRNA screens using the same assays. This is vital to help increase confidence in actives. The GeneArt® Lentiviral CIRSPR Arrayed Kinase Library (or brand name equal) and GeneArt® Lentiviral Arrayed Cas9 Library (or brand name equal) must meet the following requirements: 1.Contractor must provide an arrayed lentiviral guide particles with guide per well that will help with arrayed careening. 2.Contractor must provide an arrayed CIRSPR without the use of lentiviral vectors or plasmids to corroborate and complement siRNA screen data. 3.Contractor must provide an arrayed format as synthetic guides. 4.Contractor shall develop and screen the assay and follow up with NCATS on the procedures and results. The following specifications are required: 1.GeneArt® Lentiviral Arrayed Kinase Library (or brand-name equal) •Contractor must provide up to 200 uL of each GeneArt® Lentiviral Arrayed Kinase Particles (or brand-name equal). •Contractor must provide the respective plate maps and clone information. •Contractor must provide a lentivirus spot titer via antibiotic selection and GFP percentages on HT1080 cell lines in a 96-well format, or p24 measurement by ELISA. 2.GeneArt® Lentiviral Arrayed Cas9 Library (or brand-name equal) •Contractor must provide the GeneArt® Lentiviral Arrayed Cas9 Particles (or brand name equal). •Contractor must provide the respective plate maps and clone information. •Contractor must provide a lentivirus titer via antibiotic selection, GFP percentages on HT1080 cell lines in a 96-well format, or p24 measurement by ELISA. Anticipated period of performance: Delivery is anticipated within 30 days after Contractor's receipt of the purchase order. Capability statement /information sought. Contractors that believe they possess the ability to provide the requirement should submit documentation of their ability to meet each of the project requirements to the Contract Specialist. The response should directly and specifically state in the, capabilities statement, which project requirements you can supply. Contractors must also provide their Company Name, DUNS Number, Physical Address, Point of Contact, and Size and Type of Business (e.g., 8(a), HubZone, etc.) pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2" x 11" paper size, with 1" top, bottom, left and right margins, and with single or double spacing. The information submitted must be must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein. A cover page and an executive summary may be included but is not required. The response is limited to ten (10) page limit. The 10-page limit does not include the cover page, executive summary, or references, if requested. The response must include the respondents' technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses. All responses (capability statements) sent in response to this Small Business Sources Sought Notice must be submitted electronically (via e-mail) to the Contract Specialist. Facsimile responses are NOT accepted. The response must be submitted to Samantha Kelly, Contract Specialist at e-mail address Samantha.Kelly2@nih.gov. The response must be received on or before September 8, 2015 at 8:00AM, eastern time. "Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)."
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-01/HHS-NIH-NIDA-SSSA-SBSS-2015-820/listing.html)
- Record
- SN03866223-W 20150903/150902000152-e6cabad068b536a7308147fd226ddf70 (fbodaily.com)
- Source
-
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