SOLICITATION NOTICE
66 -- Bruker Nano Bioscope Resolve SPM System--Premium Package
- Notice Date
- 8/24/2015
- Notice Type
- Presolicitation
- NAICS
- 333314
— Optical Instrument and Lens Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- HHS-NIH-NHLBI-CSB-(EB)-2015-226-DLM
- Archive Date
- 9/15/2015
- Point of Contact
- Dorothy Maxwell, Phone: 301-435-0352
- E-Mail Address
-
maxwelld@mail.nih.gov
(maxwelld@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- INTRODUCTION: THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR A PROPOSAL. A SOLICITATION DOCUMENT WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. The National Heart, Lung, and Blood Institute (NHLBI) Office of Acquisition (OA) intends to negotiate and award a purchase order on a non-competitive sole source basis to Bruker Nano, 112 Robin Hill Road, Santa Barbara, California to provide the following for the National Institute of Health (NIH), National Institute of Biomedical Imaging and Bioengineering (NIBIB). BRAND NAME: BRUKER NANO INC. Product: Contract line items : 1. Resolve-SYS-Resolve SPM System, Configured System-Premium Package, Item Number: 0010, Quantity: One Each; Including Trade-In: Bioscope Bio-Z/BS2-121Z, bioscope scanner base, DMLS/DMLS355 bioscope scanner head and Nanoscope IIIa NS3a/2701 Controller; 2. ITCS3-Three Days Installation and Training for New Systems, Item Number: 0020, Quantity: One Each; and 3. Freight Charges. Background: The National Institute of Health (NIH) is the nation's leading medical research agency and the primary Federal agency seeking fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. The mission of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) is to improve health by leading the development and accelerating the application of biomedical technologies. The Institute is committed to integrating the physical and engineering sciences with the life sciences to advance basic research and medical care. This is achieved through: research and development of new biomedical imaging and bioengineering techniques and devices to fundamentally improve the detection, treatment, and prevention of disease; enhancing existing imaging and bioengineering modalities; supporting related research in the physical and mathematical sciences; encouraging research and development in multidisciplinary areas; supporting studies to assess the effectiveness and outcomes of new biologics, materials, processes, devices, and procedures; developing technologies for early disease detection and assessment of health status; and developing advanced imaging and engineering techniques for conducting biomedical research at multiple scales. The Nanoinstrumentation and Force Spectroscopy Section (NFSS) (http://www.nibib.nih.gov/research/labs-at-nibib/laboratory-cellular-imaging-and-macromolecular-biophysics-lcimb-0 ), Laboratory of Cellular Imaging and Macromolecular Biophysics, NIBIB, develops novel and innovative approaches to the investigation of both clinical and basic biophysical research problems. NFSS scientists have expertise in key areas such as sophisticated instrumentation, and development of one-of-a-kind experimental platforms, particular atomic force microscopy, force spectroscopy, and multimodal instruments and their insightful applications in biology and medicine. NFSS scientists collaborate closely within NIBIB, across NIH and the world. The requested purchase will upgrade our NIBIB BioAFM facility as shared with the Scanning Probe Microscope Unit of the Trans-NIH Shared Resource on Biomedical Engineering and Physical Science (BEPS) at NIBIB. The proposed Bioscope Resolve AFM package are critical components to combine with our existing components and AFM systems to investigate cancer cells and to observe fast nanoscale macromolecular dynamic process of great medical importance. To achieving the scientific objectives the procurement of Bruker Nano Resolve SPM Microscope System upgrade package is needed. Purpose and Objectives : Bruker Nano Inc. AFM platform upgrade is a critical tool for continuing this biomedical research program. The procurement will benefit NIBIB's scientific program for many years to come. The immediate projects include: • Multimodal AFM of Nanoprobes and Nanomedicine on targeted therapy of cancer cells in collaboration with NIBIB scientists, we are characterizing many nanoconstructs for applications ranging from cellular imaging to in vivo photothermal therapy (PTT) to nanodrug delivery (NDD). We are investigate small but critical differences between various cancer cells either containing driver mutations or epigenetic changes such as multi-drug resistances to be overcame in clinical translation of new nanomedicines. • NIBIB is working on tissue engineering projects to better understand collagen gel and similar biomaterial that can modulate cellular migration and development important to whole spectrum of biology and medicine. NIBIB's scientific progress requires the most advanced multimodal AFM platforms that can combine optical identification of the components in these nanoconstructs with their AFM images under fluid and in air with highest resolution, stability, and cellular observations. This package would allow scientific researchers to rebuild a more flexible and open AFM-platform for multimodal instruments in the coming years from an existing system that is outdated by about 3 generations in AFM components. Justification: This acquisition is an upgrade toward next generation Atomic Force Microscopy that can image single macromolecules at higher resolution and speed and more complete and premium features that allows investigations from live cells to single molecules. Furthermore, the new premium package from this upgrade will share components and user experience with existing systems from the same vendor to expand our core capability and sample investigation throughput greatly. Such sharing will enhanced our staff and collaborator efficiency and create additional cost savings during the project period. These AFM has particular features that all contributed greatly to our science. The new Bioscope Resolve AFM is the next generation in development by the same vendor to the Multimode-AFM and Bioscope-Catalyst system above, but updates a previous generation (classical IIIa) Bioscope AFM that has served at NIH for over ten years and are about 20 time slower and many times less precise. Period of Performance: Delivered Upon Award Regulatory Authority : This acquisition is conducted under the authority of the Federal Acquisition Regulations (FAR) Subpart 13.106-1(b) Soliciting from a single source, only one responsible source and no other supplies or services will satisfy agency requirements. Additional Information : Industry Classification (NAICS) Code is 334516, Analytical Laboratory Instrument Manufacturing and the Small Business Size Standard is 500 Employees. The acquisition is being conducted under FAR Part 13, simplified acquisition procedures, therefore the requirements of FAR Part 6 B Competitive Requirements are not applicable (FAR Part 6.001). The resultant Contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 05-83 (August 5, 2015). This requirement is under the Simplified Acquisition Threshold of $150,000.00. This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received August 31, 2015 and must reference synopsis number HHS-NIH-NHLBI-CSB-(EB)-2015-226-DLM, may be submitted to the National, Heart, Lung and Blood Institute, Office of Acquisition, COAC Services Branch, 6701 Rockledge Drive, Suite 6149, Bethesda, Maryland 20892-7902, Attention: Dorothy Maxwell. Response may be submitted electronically to maxwelld@mail.nih.gov. Faxes will not be accepted. Responses will only be accepted if dated and signed by an authorized company representative. "All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency."
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