SOLICITATION NOTICE
66 -- Infrared Imaging System for NINDS Neuronal Cytoskeletal Protein Regulation Section
- Notice Date
- 8/13/2015
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-CSS-15-715
- Archive Date
- 9/9/2015
- Point of Contact
- Lauren M. Phelps, Phone: 3015942490
- E-Mail Address
-
lauren.phelps@nih.gov
(lauren.phelps@nih.gov)
- Small Business Set-Aside
- Total Small Business
- Description
- Infrared Imaging System for NINDS Neuronal Cytoskeletal Protein Regulation Section Competitive Combined Synopsis/Solicitation HHS-NIH-NIDA-SSSA-CSS-15-715 INTRODUCTION This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. The solicitation number is HHS-NIH-NIDA-SSSA-CSS-15-715 and the solicitation is issued as a request for quotation (RFQ). NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE The intended procurement is classified under NAICS code 334516 with a Size Standard of 500 Employees. SET-ASIDE STATUS This acquisition is 100% set-aside for small businesses. ACQUISITION AUTHORITY This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures and FAR Part 12-Acquisition of Commercial Items, and is NOT expected to exceed the simplified acquisition threshold. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2005-83, dated August 5, 2015. The resultant contract will include all applicable provisions and clauses in effect through this date. DESCRIPTION OF REQUIREMENT Background The National Institute of Neurological Disorders and Stroke (NINDS) is a part of the NIH, and conducts research into the causes, treatment, and prevention of neurological disorders and stroke. The NINDS mission is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. A critical part of the NINDS mission is to study the effect of disease-causing mutations on the structure and function of the nervous system and muscle cell function. NINDS uses infrared imaging to detect proteins and quantitate the changes in proteins after treatment.The analysis of these mutant proteins involves using several different models including cell lysates, whole cells, tissue from human and animals, and in vivo studies in small animals. Presently the NINDS has been using this method to examine the cellular dynamics of various compounds to effectively change the toxicity of a mutant protein. Purpose The purpose of this acquisition is purchase of one (1) infrared imaging system for use in research projects that identify and analyze changes in proteins that contribute to neurological and neuromuscular disease. The purchase shall incorporate trade-in of an existing Li-Cor, Inc. Scanner Gel System (Model No. 920101, Serial No. 688). Project Requirements The NINDS Neurogenetics Branch requires one (1) infrared imaging system which meets the following requirements: 1. The system must offer simultaneous, two-channel detection for multiplex sample analysis and/on normalization. The channels shall be 700 nm and 800 nm. 2. For each channel, the system must include a dedicated and optimized laser and detection system. 3. The system must include two infrared, solid-state laser diodes emitting at 685 nm +5 nm and 785 nm +5nm, respectively. These infrared lasers must be the means of excitation of fluorescent labels. 4. The instrument's detection system must be based on single point detection by cooled Avalanche Photodiodes (APDs). 5. The instrument's laser lifetime must be warranted to exceed 40,000 hours of operation before failure. 6. The instrument must offered detection of fluorescent dyes within the ranges (710 nm - 730 nm) to (810 nm - 830 nm) for the 700 nm and 800 nm channels, respectively. No excitation/ detection thresholds below 700 nm will be accepted. 7. The instrument must provide automatic image capture capability that offers a dynamic range of greater than 6 logs in a single capture. 8. The instrument must provide linear dynamic range of the detection system for at least 5 orders of magnitude. 9. The instrument must include a laser/microscope that is integrated into a precision scanning mechanism capable of scanning at resolutions of 21 - 337 μm. 10. The system must utilize a sealed, flatbed-scanning surface to accommodate varying sample media (membranes, multi-well plates, gels, small animals, slides, etc.). 11. The system must offer two-color quantitative membrane- based Western blot analysis with signals being simultaneously detected at 700 nm and 800 nm. 12. The system must offer simultaneous 2-channel detection of infrared-labeled or NIR-stained nucleic acids using either agarose or PAGE gels. 13. The system must offer two-color quantitative detection of In-Gel Western assays for the immediate detection of proteins prior to blotting. 14. The system must offered quantitative detection of target molecules (typically proteins) in cells grown in 6- to 384-well plates. Quantitative analysis must be possible for all target molecules.Normalization of the target molecule by the cell number must be possible by simultaneous and quantitative detection of a second target protein or quantitative detection of nucleic acids. 15. The system must offer near infrared in vivo detection of fluorescently probed targets in small animals like mouse or rat. The system must be capable of providing a common platform for in vitro and in vivo experiments. 16. The system must offer quantitative detection of Coomassie stained protein gels 17. The system must have software that is compatible with both Apple and Windows software. 18. The system must be one that can be serviced and repaired at the NIH site, should a future need arise. The NIH shall not consider equipment that would have to be sent back to the manufacturer should maintenance be required. The required system shall be purchased in conjunction with a trade-in of an existing Li-Cor, Inc. Scanner Gel System (Model No. 920101, Serial No. 688). Offerors must be able to provide a quotation which includes trade-in of this existing equipment. Additionally, the contractor shall provide F.O.B Destination shipping/delivery, shall install the equipment at the NIH facility, and shall provide four (4) hours of training on use of the instrument for eight (8) people. Period of Performance The Contractor shall deliver and install the required equipment within sixty (60) days after receipt of order. The equipment shall be delivered between the hours of 8:00 AM to 5:00 PM, Bethesda, MD local prevailing time, Monday through Friday. Contract Type The Government intends to issue a firm fixed price purchase order for this requirement. EVALUATION CRITERIA FAR clause 52.212-2, Evaluation - Commercial Items applies to this acquisition and the specific evaluation criteria to be included in paragraph (a) of that provision are as follows: The Government will award a purchase order resulting from this solicitation on the basis of best value, technical factors and price considered. Technical factors together shall be considered more important than price. The technical evaluation factors are as follows, in order of importance: Mandatory Criteria: Trade-In The Offeror MUST include trade-in of the NINDS owned equipment in its quotation. Factor 1: Technical Approach The Offeror shall detail in its technical proposal how it shall meet each of the project requirements. This shall include the specifications and capabilities of the offered equipment in relation to the above detailed requirements. The Government shall particularly evaluate the proposed equipment for meet or exceed the requirements for quantitative detection capabilities, in vivo detection capabilities, and two-color analysis capabilities. Factor 2: Delivery, Installation, and Training The Offer shall detail in its technical proposal how it shall meet the delivery, installation, and training requirements. The Government shall particularly evaluate ability to meet or exceed delivery and installation schedule requirements. Quotations must include a delivery lead time. RESPONSE FORMAT Responses to this solicitation must include clear and convincing evidence of the offeror's capability of fulfilling the requirement as it relates to the technical evaluation criteria. The offeror must submit a technical response and a separate price quotation. The technical response should be prepared in reference to the evaluation criteria identified in this solicitation and may be up to ten single-sided pages. The price quotation must include the requirements listed above as well as associated pricing. Contractors must provide their Company Name, Dun & Bradstreet Number (DUNS), Taxpayer Identification Number (TIN), Business Size, Physical Address, and Point of Contact Information in their responses. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." APPLICABLE CLAUSES AND PROVISIONS INCORPORATED BY REFERENCE The following FAR clauses and provisions shall apply to this solicitation: 1. All Offerors MUST be actively registered in the System for Award Management (SAM) www.sam.gov. 2. The provision at FAR clause 52.212-1, Instructions to Offerors - Commercial Items (April 2014), applies to this acquisition. 3. A completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications - Commercial Items (March 2015), is required with any offer submitted. This requirement may be met by completion of the provision in the System for Award Management. 4. FAR clauses 52.212-4, Contract Terms and Conditions - Commercial Items (May 2015) and 52.212-5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items (May 2015) apply to this acquisition. 5. The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. In addition, the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All Offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." NOTE Responses to this solicitation must include sufficient information to establish the interested parties' bona-fide capabilities of providing the product or service. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered in the award decision. CLOSING STATEMENT All responses must be received by the closing date of this announcement and must reference solicitation number HHS-NIH-NIDA-SSSA-CSS-15-715. Responses shall be submitted electronically via email to Lauren Phelps, Contract Specialist, at lauren.phelps@nih.gov.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-2/HHS-NIH-NIDA-SSSA-CSS-15-715/listing.html)
- Place of Performance
- Address: Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN03838308-W 20150815/150814000307-ce7d394e2f5a9ce128e4313624352785 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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