SOLICITATION NOTICE
70 -- Establish a way for the Monarch Initiative Portal to include de-identified
- Notice Date
- 8/6/2015
- Notice Type
- Presolicitation
- NAICS
- 611310
— Colleges, Universities, and Professional Schools
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- HHS-NIH-NHLBI-CSB-(HG)-2015-202-DLM
- Archive Date
- 8/28/2015
- Point of Contact
- Dorothy Maxwell, Phone: 301-435-0352
- E-Mail Address
-
maxwelld@mail.nih.gov
(maxwelld@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- INTRODUCTION: THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR A PROPOSAL. A SOLICITATION DOCUMENT WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. IT SECURITY PROVISIONS AND 508 COMPLIANCE LANGUAGE IS ALREADY OBTAINED FROM PREVIOUS CONTRACT. FEDERAL ACQUISITION REGULATION(48 CFR Part 52) - PRIVACY ACT RELATED CLAUSES WILL BE APPLICBLE. The National Heart, Lung, and Blood Institute (NHLBI) Office of Acquisition (OA) intends to negotiate and award a purchase order on a noncompetitive sole source basis to Oregon Health & Sciences University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239 is to establish a way for the Monarch Initiative Portal to include de-identified UDP patient data along with the model organism data in order to assist in soliciting collaborations with outside investigators for the National Institute of Health (NIH), National Human Genome Research Institute (NHGRI). Follow-On Requirement Procurement: Aim 1: Create public-facing web pages with de-identified genotype and phenotype information for UDP cases. The pages will be visible in part of the Monarch Initiative web portal, and will be reachable via existing basic and advanced search mechanisms (for example, find all patients with neurological and immune system phenotypes). The page will integrate relevant information from other sources. Aim2: Create a tool that can be used by researchers and clinicians that can operate on patient data (for example, data extracted from the UDPICS database). The tool will not be web based, and is intended to be executed either within the researcher's desktop environment Background: The sole source determination is based on the fact that the National Institute of Health (NIH) mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. The National Human Genome Research Institute (NHGRI), mission has expanded to encompass a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. The National Human Genome Research Institute (NHGRI), Undiagnosed Disease Program (UDP) is a program designed to address the needs of persons with debilitating medical conditions for which no diagnosis has been found despite an extensive workup. The goals of the UDP include finding accurate diagnoses and discovering new diseases that provide insight into human physiology and genetics. The UDP was established to evaluate participants who have undiagnosed medical conditions. UDP participants have generally received extensive diagnostic workups before traveling to the NIH and often have numerous and/or complex medical problems. The UDP program makes use of a diverse set of diagnostic and research techniques both to attempt to find a diagnosis and to generate research projects to advance medical knowledge. The Oregon Health & Sciences University Ontology Development Group headed by Dr. Melissa Haendel in the Department of Medical Informatics has previously developed a novel algorithm that is used to map similar phenotypes across species (OWLSim) and tools for recording human phenotypes in human phenotype ontology terms (Phenotips). These tools and algorithms have been incorporated into the UDP LIMS pipeline to systematically define and describe patient clinical phenotypes into universal terms. Purpose and Objectives: The objective is to continue with Oregon Health & Science University to establish a way for the Monarch Initiative Portal to include de-identified UDP patient data along with the model organism data in order to assist in soliciting collaborations with outside investigators. Provide a resource that incorporates UDP patient de-identified data to link to model organisms to explore genomic data in both humans and model organisms. Further develop the current system that operates behind the NIH firewall to show the relationship of the patient and how the phenotype is connected to phenotypic attributes, signaling pathways, and biochemical pathways. The base system has been implemented in the UDP LIMS 24/7 system. Period of Performance: 12 Months Upon Award Justification: This technology supports the research needs of the UDP by allowing a portal interface to compare phenotypic data with model organism data in order to foster collaboration on UDP research projects. Requirements for this acquisition are as follows: • Contractor shall create and design public web pages that contain de-identified genotypic and phenotypic UDP patient information: o Shall be part of the Monarch Initiative web portal. o Shall be reachable through existing basic and advance search mechanisms o Shall integrate relevant information from other sources (orthologous information, Exomiser results, etc.) o Shall develop a custom website to capture feedback or questions as determined by the NIH UDP. o Shall work with Federal ethics and privacy staff to assure adequate privacy protections are in place. • Contractor shall create a non-web-based tool for UDP clinicians and researchers to view and manage patient data behind the NIH UDP firewall that will: a. Generate reports on clusters of potentially similar UDP cases; b. Generate reports on similar known and new diseases; and c. Generate reports on similar matching models • The requirements of this UDP tool must contain the following features: o Must be an extension of the Monarch Initiative OwlSim Phenotype similarity tool; o Must employ standard clustering techniques using OwlSim output' o Must provide visualization of clustered information either through 3rd party libraries or integration environments such as Cytoscape; o Must work with the NIH UDP to test the result displays, including network diagrams o Must integrate this tool into UDPics; and o Must accommodate an external data source to search outside data generated by the UDN with updates from the UDP gateway. Regulatory Authority: This acquisition is conducted under the authority of the Federal Acquisition Regulations (FAR) Subpart 13.106-1(b) Soliciting from a single source. Additional Information: Industry Classification (NAICS) Code is 622110, General Medical and Surgical Hospitals with size standard in dollars $38.5M Per Annum. The acquisition is being conducted under FAR Part 13, simplified acquisition procedures, therefore the requirements of FAR Part 6 B Competitive Requirements are not applicable (FAR Part 6.001). The resultant Contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 05-83 (July 2, 2015). This requirement is under the SAT of $150,000.00. This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received no later than 7:30 a.m. Eastern Standard Time (EST), August 13, 2015; and must reference synopsis number HHS-NIH-NHLBI-CSB-(HG)-2015-202-DLM, may be submitted to the National, Heart, Lung and Blood Institute, COAC Services Branch, Office of Acquisitions, Office of Management, 6701 Rockledge Drive, Suite 6149, Bethesda, Maryland 20892-7902, Attention: Dorothy Maxwell. Response may be submitted electronically to maxwelld@mail.nih.gov. Faxes will not be accepted. Responses will only be accepted if dated and signed by an authorized company representative. "All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency."
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