SOLICITATION NOTICE
Q -- Laboratory Testing Services to Analyze the Herbicide Glyphosate in Residential Dust Samples from the California Childhood Leukemia Case-Control Study to Evaluate Risk of Childhood Leukemia
- Notice Date
- 8/4/2015
- Notice Type
- Presolicitation
- NAICS
- 621511
— Medical Laboratories
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E128, Rockville, Maryland, 20852, United States
- ZIP Code
- 20852
- Solicitation Number
- N02CP52650-76
- Archive Date
- 8/19/2015
- Point of Contact
- Catherine Muir, Phone: (240) 276-5434
- E-Mail Address
-
muirca@mail.nih.gov
(muirca@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Contracting Office Address: Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E144, Bethesda, MD 20892, UNITED STATES Description: National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (DCEG), Occupational and Environmental Epidemiology Branch (OEEB), plans to procure on a sole source basis the services for herbicide glyphosate analyses testing in residential dust samples from Battelle Memorial Institute, 505 King Avenue, Columbus, OH 43201. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(2) and is exempt from the requirements of FAR Part 6. The North American Industry Classification System code is 621511 and the business size standard is $32.5M. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price, Base Period, and One (1) twelve (12) month Term Option Period type contract. The period of performance of the Base Period is twelve (12) months from date of award, and the One (1) Term Option Period will be no more than twelve (12) months. It has been determined there are no opportunities to acquire green products or services for this procurement. The Division of Cancer Epidemiology and Genetics (DCEG) is a research program of the National Cancer Institute (NCI), one of the National Institutes of Health (NIH). The Division is the world's most comprehensive cancer epidemiology research group. Its renowned epidemiologists, geneticists, and biostatisticians conduct population and multidisciplinary research to discover the genetic and environmental determinants of cancer and new approaches to cancer prevention. The Division's research impacts public health policy in the United States and around the world. The Occupational and Environmental Epidemiology Branch (OEEB), DCEG, NCI, NIH conducts studies in the United States and abroad to identify and evaluate environmental and workplace exposures that may be associated with cancer risk. In 2015, the International Agency for Research on Cancer (IARC) classified glyphosate as a probable human carcinogen based on epidemiology studies of occupational exposures and B-cell cancers as well as animal and human data on chromosome damage and other health effects. Self-reported herbicide use around the home and garden during the pregnancy and the child's early life has been associated with increased risk of childhood leukemia in most studies. Glyphosate is among the top two active ingredients found in lawn and garden weed treatment products. In prior analyses of herbicides and childhood leukemia in a case-control study in California (the California Childhood Leukemia Study, (CCLS)), 2,4-D (the most commonly used herbicide) and other home/garden herbicides frequently detected in households were not associated with leukemia risk. The proposed study will evaluate the relationship between concentrations of glyphosate in homes of cases and controls and risk of childhood leukemia, specifically the most common form acute lymphoblastic leukemia (ALL). The study has several important features, including substantial regional variation in agricultural and home/garden use of herbicides; therefore, we predict a large range in concentrations in homes. Results from this study will advance the OEEB's understanding of the association between herbicide use and childhood leukemia risk. Contractor shall perform the following tasks: • In the Base Period, the Contractor shall measure the herbicide glyphosate in each 0.5 gram sieved dust sample using an isotopic dilution method. Dust samples (vials with >=0.5 gram of sieved dust) will be shipped on ice by overnight courier from the NCI Repository to the Contractor's laboratory for analyses. There will be one (1) shipment of 445 samples (400 field samples, 45 extra dust samples for quality control analyses) in the Base Year of the contract. • Samples will be extracted in batches of nine (9) CCLS samples and each batch shall also include a duplicate sample, a spiked duplicate sample, and a solvent method blank. • Each sample will be spiked with isotopically labeled glyphosate prior to extraction and analyzed using Gas Chromatography Mass Spectrometry. The method for extraction and analysis shall have been demonstrated to be valid and reproducible with a limit of detection of 0.7 ng glyphosate per gram of dust (or lower) and good glyphosate recovery rates (e.g. 80-125%). • After contract award, the first phase of this work shall begin after the shipment of samples has been received by the Contractor's laboratory. Approximately ten (10) batches shall be analyzed in the first two (2) months of the contract. The remaining thirty-five (35) batches will be analyzed from November 2015 through April 2016. • In the Option Year, work shall begin after the shipment of samples (89 samples--(eighty (80) field samples, nine (9) extra dust samples for quality control analyses) has been received by the Contractor's laboratory. The Contractor shall measure the herbicide glyphosate in each 0.5 gram sieved dust sample using an isotopic dilution method. Dust samples (vials with >=0.5 gram of sieved dust) will be shipped on ice by overnight courier from the NCI Repository to the Contractor's laboratory for analyses. There will be one (1) shipment of 89 samples (80 field samples, 9 extra dust samples for quality control analyses) in the Option Year. • Reporting and Deliverables: 1. Base Year: • The measurements and quality control sample results from the first ten (10) batches of samples shall be delivered to the attention of the NCI Contracting Officer's Representative (COR) for inspection by late October 2015. • The remaining thirty-five (35) batches will be analyzed from November 2015 through April 2016 with final data delivery to the attention of the NCI COR by late April 2016. • The sample measurement data and quality control results shall be delivered electronically as an Excel file. • An electronic, and written report shall be prepared, which describes the analytic method used including details of the extraction method and GC/MS conditions, a summary of the quality control sample results including percent recoveries of spikes and coefficients of variation for replicate samples, and any problems encountered in the sample analyses. The report describing the analysis in the Base Year shall be received by late July 2016. 2. Option Year: • The measurements and quality control sample results from the first ten (10) batches of samples shall be delivered to the attention of the NCI COR for inspection by late October 2016. • The remaining batches will be analyzed from November 2016 through April 2017 with final data delivery to the attention of the NCI COR by late April 2017. • The sample measurement data and quality control results shall be delivered electronically as an Excel file. • An electronic, and written report shall be prepared, which describes the analytic method used including details of the extraction method and GC/MS conditions, a summary of the quality control sample results including percent recoveries of spikes and coefficients of variation for replicate samples, and any problems encountered in the sample analyses. The report describing the analysis in the Base Year shall be received by early July 2017. This laboratory testing service is provided by Battelle Memorial Institute. The proposed source is the only known laboratory that can perform all the technical requirements needed in the Statement of Work. The proposed source has demonstrated extensive and unique experience in the measurement of glyphosate in house dust samples from large epidemiologic studies that is not available from any other known source. They have actively developed and tested the methodology to measure glyphosate in house dust samples as part of their research program. These tests are required to support on-going studies that are part of a comprehensive, multidisciplinary, intramural research program within the DCEG that focus on providing insight into cancer etiology, chemical carcinogenesis, and mechanisms of action to identify and evaluate environmental and workplace exposures that may be associated with cancer risk. The OEEB's studies are on-going, and the performance characteristics and quality of the needed services are required for maintaining the integrity of these on-going studies. A change would be disruptive to the ability to analyze the cumulative results. This notice is not a request for competitive quotation. However, if any interested party, especially small businesses, believes it can meet the above requirement, it may submit a capability statement, proposal, or quotation, which shall be considered by the agency. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow the NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 9:00AM EDT, on August 18, 2015. All responses and questions must be in writing and faxed (240) 276-5401 or emailed to Catherine Muir, Contracting Officer via electronic mail at muirca@mail.nih.gov. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, Contractors must be registered and have valid, current Entity Record, including current Representations and Certifications, in the System for Award Management (SAM) through SAM.gov. Reference: N02CP52650-76 on all correspondence.
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