SOURCES SOUGHT
59 -- Electonic Field and Stimulation Kit
- Notice Date
- 4/20/2015
- Notice Type
- Sources Sought
- NAICS
- 423690
— Other Electronic Parts and Equipment Merchant Wholesalers
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-SBSS-15-283
- Archive Date
- 5/15/2015
- Point of Contact
- Andrea McGee, Phone: 3014358718
- E-Mail Address
-
amcgee@nida.nih.gov
(amcgee@nida.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- SOLICITATION NUMBER: HHS-NIH-NIDA-SSSA-SBSS-15-283 TITLE: Electonic Field and Stimulation Kit INTRODUCTION This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Purpose and Objectives: The purpose of this requirement is the purchase of Electronic Field Stimulation (EFS) Kit for the existing Hamamatsu FDSS/uCELL Imaging Plate Reader is being requested by the TRND group in order to measure the activities of voltage-gated ion channels in neurons and cardiomyocytes differentiated from induced pluripotent stem cells. Project Background: The mission of The National Center for Advancing Translational Sciences (NCATS) is to apply the tools of small molecule screening and discovery to the development of chemical probe research tools, for use in the study of protein and cell functions, and biological processes relevant to physiology and disease. This request will enable the NCATS and TRND group to increase the capability to utilize their existing Hamamatsu FDSS/uCell Imaging plate Reader, which measure fluorescence signals kinetically. Currently, the existing plate reader only measures the cellular ion channel activities in response to agonist/activator stimulation. The ion channel activation by electronic stimulation cannot be measured with the existing instrument. The newly available Electronic Field Stimulation (EFS) Kit, a device with 96-electronic probes, is an accessory device to the existing FDSS/uCELL Imaging Plate Reader which allows the recording of the ion channel response to electronic stimulation. With this new accessory device, we will be able to measure the activities of voltage-gated ion channels in neurons and cardiomyocytes differentiated from induced pluripotent stem cells. This currently cannot be done with our existing instrumentation. Cell surface voltage-gated ion channels are important biomarkers for excitable cells including neuronal cells, cardiomyocytes, muscle cells, and secretory cells. Measurements of functions of cell surface ion channels such as calcium channel, potassium channels and sodium channels are extensively used for characterization of neuronal and muscle cells as well as the detection of disease phenotypes. Our group is working on the differentiation of neuronal cells and cardiomyocytes from patient-derived induced pluripotent cells that are used as disease models for drug development. We need an instrument that can be used to measure ion channel functions in the differentiated neuronal cells and cardiomyocytes for characterize the differentiated cells and for compound screen. This new Electronic Field Stimulation accessory kit, with 96-electrode, sends electric signals to cells instead of chemicals to achieve desirable stimulation to cells. It is useful for performing high throughput iPS cardiomyocytes and primary neuronal assays. Project Requirements: Specifically, the NCATS TRND requires the following: 1. Accessory device with 96 electrodes in an array of 8x12, fitting a 96 well plate 2. Device and software should work seamlessly with Hamamatsu FDSS/uCELL instrument 3. Electronic stimulations generated from the device should have the following specifications: a. Frequency 0.1-50 Hz b. Pulse width of 1 to 100ms c. Number of pulse: 1-1000 d. Voltage of 1.0 to 20v 4. Each column of 8 electrodes should be individually controlled Anticipated period of performance: 60 days ARO CAPABILITY STATEMENT Contractors that believe they possess the ability to provide the required equipment should submit documentation of their ability to meet each of the project requirements to the Contract Specialist. Contractors should also provide their Company Name, DUNS number, Physical Address, and Point of Contact Information. Interested organizations are required to identify their type of business, applicable North American Industry Classification System Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number. All capability statements sent in response to this Small Business Sources Sought Notice must be submitted electronically (via email) to Andrea McGee, Contract Specialist @ andrea.mcgee@nih.gov. on or before April 30, 4:00 p.m. eastern time. The response must in in Microsoft Word, Adobe PDF format using 11-point or 12-point font, 8-1/2" x 11" paper size, with 1" top, bottom, left and right margins, and with single or double spacing. Disclaimer and Important Notes. This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-2/HHS-NIH-NIDA-SSSA-SBSS-15-283/listing.html)
- Place of Performance
- Address: 9800 Medical Center Drive, Rockville, Maryland, 20850, United States
- Zip Code: 20850
- Zip Code: 20850
- Record
- SN03704926-W 20150422/150420235527-d4957ff03e13dd29766004c00ca31581 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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