SOURCES SOUGHT
66 -- Upgrading the photo-detectors on multi-photon microscopes for high-sensitivity in vivo imaging
- Notice Date
- 7/10/2014
- Notice Type
- Sources Sought
- NAICS
- 333314
— Optical Instrument and Lens Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-SSSA-SS382
- Archive Date
- 8/8/2014
- Point of Contact
- Andrea McGee, Phone: 3014358718
- E-Mail Address
-
amcgee@nida.nih.gov
(amcgee@nida.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- INTRODUCTION This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement. This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Purpose and Objectives: The purpose of this acquisition is to provide the new GaAsP photodector module to replace the old detectors on our existing FV1000 multiphoton microscope, and provide the related system upgrade. This work is intended to improve the signal detection and image quality of multi-photon microscopy for high-sensitivity imaging of brain neural activity in vivo. Project Background: Olympus FV1000 multiphoton microscope system is a crucial instrument for biomedical research. It offers a range of critical features for high-speed multicolor fluorescence imaging at submicron resolution in deep brain regions of live animals. We currently have an FV1000 microscope in the lab, and we need to upgrade this system with the newer version of photodetectors to improve our image quality for high-speed and high-sensitivity detection of neural activity in living brain. Our research program requires highly sensitive photo detection in multiple channels for in vivo brain imaging. Both high quantum efficiency and low noise are needed. In addition, the high sensitivity detector needs to be properly protected from excessive light to extend its lifetime. And the switch between conventional and high-sensitivity detectors needs to be smoothly iexecuted. The Olympus FV10MP-BXD-GAP detector module is equipped with 2 conventional multi-alkali PMTs for the routine browsing of samples, and 2 GaAsP PMTs for the highly sensitive analysis of a specific ROI. Switching between the two types of detector is easy and fast, providing a hassle-free workflow. To further lengthen the lifetime of the GaAsP PMT, the system prevents any unnecessary exposure to ambient light such as room lighting or excessive fluorescence. Exceptional sensitivity is achieved by coating the photoelectric surface of the detector with Gallium Arsenide Phosphide (GaAsP), which offers superior quantum efficiency compared to conventional PMTs. In addition, noise is kept to an absolute minimum via the use of Peltier cooling, boosting signal-to-noise ratio. The detector unit also includes standard PMTs, allowing these to be used for identifying regions of interest (ROI) which can then be scanned using the GaAsP PMTs, maximising their lifetime. An Olympus FV1000 multiphoton microscope system currently exists in the lab. The new detector must be integrated with the existing microscope hardware and software control systems. The new photodetector module will directly replace the old detector on the existing Olympus FV1000 multiphoton microscope system. The new photodetector module will be integrated into the existing microscope hardware and software control systems by the manufacturer's design. Required Delivery Date: 2 weeks ARO CAPABILITY STATEMENT Contractors that believe they possess the ability to provide the required equipment should submit documentation of their ability to meet each of the project requirements to the Contract Specialist. Contractors should also provide their Company Name, DUNS number, Physical Address, and Point of Contact Information. Interested organizations are required to identify their type of business, applicable North American Industry Classification System Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number. All capability statements sent in response to this Sources Sought Notice must be submitted electronically (via email) to Andrea McGee, Contract Specialist @ andrea.mcgee@nih.gov. on or before July 24, 2014, 4:00 p.m. eastern time. Facsimile responses will be accepted at 301-480-1358. The response must in in Microsoft Word, Adobe PDF format using 11-point or 12-point font, 8-1/2" x 11" paper size, with 1" top, bottom, left and right margins, and with single or double spacing. Disclaimer and Important Notes. This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-2/HHS-NIH-NIDA-SSSA-SS382/listing.html)
- Place of Performance
- Address: 9000 Rockville Pike, Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN03420930-W 20140712/140710235332-abd081100ea1a4504ef3fb45b6a1fb97 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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