SOURCES SOUGHT
68 -- TRH AGONIST
- Notice Date
- 6/5/2014
- Notice Type
- Sources Sought
- NAICS
- 541711
— Research and Development in Biotechnology
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, Nat'l Institute of Diabetes, Digestive, & Kidney Diseases, 2 Democracy Plaza, Suite 700W, 6707 Democracy Blvd., MSC 5455, Bethesda, Maryland, 20892-5455
- ZIP Code
- 20892-5455
- Solicitation Number
- NIHLM2014174
- Archive Date
- 7/1/2014
- Point of Contact
- V. Lynn Griffin, Fax: 301-480-8501, MAXWELL KIMPSON,
- E-Mail Address
-
griffinv@mail.nih.gov, Max.Kimpson@nih.gov
(griffinv@mail.nih.gov, Max.Kimpson@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This Small Business Sources Sought Notice is for information and planning purposes only and shall not be construed as a solicitation or as an obligation or commitment by the Government. This notice is intended strictly for Market Research. The National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases is conducting a market survey to determine the availability and technical capability of qualified small business, veteran-owned small business, service-disabled veteran-owned small business or HUBZone small businesses capable of providing TRH agonist. NIDDK/NIH has requested this procurement to develop a molecular ("homology") model of the thyrotropin-releasing hormone (TRH) receptor, use the model to rationally design "drug-like" ligands that bind to and activate the TRH receptor and then to chemically synthesize the ligands. This will be an iterative process in which a batch of ligands will be designed and synthesized then tested in a NIDDK laboratory and then based on the results of the tests another round of design, synthesis and testing will be pursued, etc. The purpose will be to develop a high affinity and potency agonist for the TRH receptor that may be a lead drug to treat humans with central nervous system disorders and cancer-related fatigue. There is no prior work in this area. It is noteworthy that a number of pharmaceutical companies have synthesized thousands of analogs of TRH but although they are active in vitro they are virtually ineffective when tested in animal models because of their rapid degradation in blood and their inability to penetrate the blood-brain barrier. A drug-like TRH receptor agonist may have a much longer halfllfe In blood and ability to penetrate the blood-brain barrier. NIDDK has requested Hit-to Lead optimization of compound 18 for TRH agonist activity. The process will involve, molecular modeling, purchase of desired compounds and synthesis of new compounds to Improve TRH agonist activity. Contractor shall establish an SAR and exploration of novel intellectual property (IP) positions. Contractor shall work closely with NIDDK scientists and will include results of their biological tests in designing new sets of compounds. Project Timeline: This Is an Integrated project and shall require 6 months. Deliverables: a. Molecular modeling study b. Design of new compounds c. Procurement of about 25 commercially available compounds d. Synthesis of about 20 new compounds with > 95% purity in 20 mg quantity e. Intellectual Property (IP) search f. Project report The intended procurement will be classified under North American Industrial Classification (NAICS) code 541711with a size standard of 500. Offerors who are capable of providing at a minimum, fifty-one percent (51%) of the required/actual services of this solicitation. All respondents are requested to identify their firm's size and type of business. Interested firms responding to this market survey must provide (a) capability statement demonstrating their experience, skills and capability to fulfill the Government's requirements for the above. The capability statement shall be in sufficient enough detail, but not to exceed 15 pages, so that the Government can determine the experience and capability of your firm to provide the requirements above. Your capability statement, not to exceed 15 pages, should include references. Capability statement must be received at the address identified in this synopsis no later than 11:00 A.M. local time at designated location) on June 16, 2014. Responses by FAX or E-MAIL WILL NOT BE ACCEPTED. This synopsis is for information and planning purposes and is not to be construed as a commitment by the Government, nor will the Government pay for information solicited. Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provided feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate response to a solicitation. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)." Any questions regarding this announcement must be sent via email to griffinv@mail.nih.gov and must include solicitation NIHLM2014174 in the subject line of email. PLEASE NOTE: In order to receive an award, contractor must be registered and have valid certification in the System for Award Management (SAM) [formerly CCR].
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDDKD/NIHLM2014174/listing.html)
- Record
- SN03386902-W 20140607/140605235334-b8fb3a71a4b81871570d6324eca22433 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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