SOURCES SOUGHT
66 -- Sources Sought for Sequencing Platform
- Notice Date
- 6/4/2014
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Allergy & Infectious Diseases/AMOB, 10401 Fernwood Drive, Suite 2NE70, MSC 4811, Bethesda, Maryland, 20817
- ZIP Code
- 20817
- Solicitation Number
- NIAIDSS14T1676396
- Archive Date
- 6/24/2014
- Point of Contact
- Jessica Portillo, Phone: 3014025760
- E-Mail Address
-
jessica.portillo@nih.gov
(jessica.portillo@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- National Institutes of Health is seeking to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code of 334516 with a size standard of 500 employees for the proposed acquisition of a Zephyr NGS Workstation plus 1 year warranty, a Sciclone NGSx Workstation plus 1 year warranty, an Air Compressor, an iBLOX Universal Table, Unit A; Pipet Tip-15, Art, box 10-96 Sterile, Zephyr NGS consumables Kit A, and Assy-kit of Sciclone NGS Consumables to perform next-generation sequencing sample preparation protocols on large numbers of nucleic acid samples from human subjects and animals. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. Background: The Vaccine Research Center at the National Institutes of Health conducts research that facilitates the development of effective AIDS vaccines. Activities in the Center include basic research to establish mechanisms of inducing long-lasting protective immunity against HIV and other pathogens that present special challenges to vaccine development, the conception, design, and preparation of vaccine candidates for HIV and related viruses, and laboratory analysis, animal testing, and clinical trials of such candidates. The VRC conducts a comprehensive program of research on the NIH intramural campus and work with scientists in academic, clinical, and industrial laboratories through a program of national and international collaborations. The VRC will actively seek industrial partners for the development, efficacy testing, and marketing of vaccines and focus the development of new methodologies and training opportunities that will benefit all HIV vaccine researchers. The potential scientific advances, methodologies, and resources will also provide the basis for research on vaccines for other diseases. Laboratory based projects/clinical support: The VRC lab's work in HIV infection in part involves analysis of the clonal composition of CD8 T cells that respond to HIV and the interaction with HIV quasispecies. Escape from adaptive T cell immunity through viral epitope mutation is considered to be a major obstacle to the development of vaccines that aim to elicit cellular immunity. The VRC investigates the molecular determinants of this phenomenon at the level of the T cell receptor-epitope contact interface, and defines structural motifs that govern the pace and pattern of epitope escape. The practical consequences of the findings suggest that vaccine strategies should elicit responding T cells that are qualitatively superior, in terms of clonotypic composition, to those elicited in natural infection. Contractor Requirements •Segregation of pre-PCR and post-PCR library preparation steps. I.e., two different robots physically separated to prevent cross-contamination. •96-well pipetting heads for processing of up to 96 samples, completely in parallel/simultaneously. (Essential feature needed) •For the pre-PCR robot, large (>20-plate) deck space with extra reserve plates to provide enough clean pipet tips so that multiple different steps requiring different reagents may all be performed with walk-away automation. I.e., a person is not required to stand by the robot as it works and replenish clean tip boxes. •Availability from the company of pre-written and validated protocols for "mRNA seq" library construction and other key protocols performed by our research group. Any potential offers should respond with their capability statement by June 9, 2014. Capability statements must reference similar work that has been performed by the offeror and the dollar value of that work. Potential offers must indicate business size in their capability statement. This is a market survey, not a request for proposals. All submissions and questions must be directed in writing, to Jessica Portillo at jessica.portillo@nih.gov.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/AMOB/NIAIDSS14T1676396/listing.html)
- Place of Performance
- Address: Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN03385083-W 20140606/140604234833-9f5e04add58df0c7f9218d2c57f798eb (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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