SOURCES SOUGHT
66 -- Irys Imaging Instrument
- Notice Date
- 5/5/2014
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- HHS-NIH-NHLBI-CSB-(HG)-SBSS-2014-113-DLM
- Archive Date
- 5/27/2014
- Point of Contact
- Dorothy Maxwell, Phone: 301-435-0352
- E-Mail Address
-
maxwelld@mail.nih.gov
(maxwelld@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice." IRYS Imaging Instrument, (Specified Brand Name: BioNano Genomics) NO REFURBISHED OR USED SYSTEMS ARE ACCEPTABLE. A. BACKGROUND : The National Institutes of Health (NIH) mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. The National Human Genome Research Institute (NHGRI) led the National Institutes of Health's (NIH) contribution to the International Human Genome Project, which had as its primary goal the sequencing of the human genome. This project was successfully completed in April 2003. Now, the NHGRI's mission has expanded to encompass a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. NHGRI supports the development of resources and technology that will accelerate genome research and its application to human health. A critical part of the NHGRI mission continues to be the study of the ethical, legal and social implications (ELSI) of genome research. NHGRI also supports the training of investigators and the dissemination of genome information to the public and to health professionals. The National Human Genome Research Institute NHGRI), NIH Intramural Sequencing Center (NISC) is a high-throughput sequencing center supporting all institutes within the NIH. NISC has served the NIH community for over 15 years as a source for high-quality large-scale sequencing and analysis. As next generation sequencing applications expand, so does the demand for NISC services. NISC has worked with a number of investigators seeking to obtain the complete de novo assembled sequence of a number novel genomes such as microbial strains, malarial strains, and ancient sea creatures such as the ctenophore. NISC have also explored several methods of identifying copy number changes and deletions in human genomes, with only limited success. Neither array data nor whole exome data has provided a satisfactory accuracy rate. NISC works with a number of investigators studying various forms of cancer. One of the hallmarks of cancer genomes is significant structural rearrangements in the genome. Data published so far required massive effort and expense to derive this information. NISC does not have the resources for such experiments. The Irys System would provide a quick and inexpensive tool for investigating such questions. B. PURPOSE AND OBJECTIVES : The NIH Intramural Sequencing Center (NISC) is a centralized research facility for performing high-throughput, large-scale DNA sequencing and sequence analysis. Contractor Requirements: • Must be able to generate a human genomic map in less than one week; • Must be able to generate a human genomic map for less than $5,000; • Must be able to generate genomic maps for microbial and fungal genomes; • Data from the instrument must provide copy number variants, translocations, haplotype info, strain identification; and • Instrument must support two color detection. Inspection and Acceptance Requirements: • Upon arrival of equipment to destination, the package must be undamaged. • In the installation of the equipment, all parts including computer must be functional and running properly. C. SCOPE OF WORK : The Irys System provides genome maps from massively parallel single-molecule visualization of extremely long DNA without amplification providing long-range contiguity critical for de novo sequence scaffolding and analysis of structural variation in complex genomes. These maps provide dense genome-wide anchor points for ordering and orienting sequencing contigs or scaffolds to greatly increase completion and accuracy of de novo assemblies. Structural variants and repeats are directly measured within long "reads" for comprehensive genome analysis. Retaining long-range contiguity is critical for de novo sequence scaffolding and analysis of structural variation in complex genomes. In comparison to many of the current short read technologies, Irys genome maps have several unique features that benefit genomic research. By unraveling and confining chromosomal-length nucleic acids, valuable information regarding placement and order of the genome is not lost, which enables comprehensive detection of variants including rearrangements, inversions, and copy- number variations, as well as accurate gap sizing. Genomic DNA is not amplified, shearing is minimized, and molecules are measured in their native form in solution. In addition, the Irys System is an open platform designed to be leveraged for other forms of genetic analysis. With an error rate of less than 1% and label site positional accuracy of < 150bp (stdev), data provided by the Irys is extremely high quality and useful in furthering the research of any organism under study. High throughput data generation (50-100Gb per run) necessary for large-genome research is accomplished through high-density nanochannel array with multi-cycle loading and imaging. Applications supported by The Irys System include, but are not limited to: • Sequence assembly: Achieve more complete de novo assemblies; • Structural variation analysis/CNV: Visualize insertions, deletions, inversions, balanced translocations, duplications, rearrangements; • NGS anchoring: Orient contigs and size gaps to improve existing sequencing assembly; • Haplotyping: Use long-range information and single-molecule readout to phase variants in heterozygous regions of diploid genomes; and Strain ID: Long labeled molecules contain high uniqueness for unambiguous mapping to genomes for sensitive detection of species or strain D. PROCUREMENT : 1. Irys automated single-molecule imaging instrument for use with irysChip and irysPrep consumables to analyze extremely long DNA molecules based on unique, proprietary nanoChannel array technology, Product: irys (US), Produce Code: IN-011-01, Quantity: One (1) Each. E. ANTICIPATED PERIOD OF PERFORMANCE : 3-4 Months Upon Receipt of Contract Award F. CAPABILITY STATEMENT/INFORMATION SOUGHT: Interested parties are expected to review this notice to familiarize itself with the requirements of this project. Failure to do so will be at your firm's own risk. The following information shall be included in the capability statement: 1. A general overview of the respondents' opinions about the difficulty and /or feasibility of the potential requirement, and any information regarding innovative ideas or concepts. 2. Information in sufficient details of the respondents' (a) staff expertise, including their availability, experience, and formal and other training; (b) current in-house capability and capacity to perform the work; (c) prior completed projects of similar nature; (d) corporate experience and management capability; and (e) examples of prior completed Government contracts, references, and other related information. 3. The respondents' DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HUBZone, etc) pursuant to the North American Industry Classification System (NAICS) code: 334516 Analytical Laboratory Instrument Manufacturing, small business size standard is 500 Employees. 4. Any other information that may be helpful in developing or finalizing the requirements of the potential acquisition. 5. The capability statement shall not exceed 10 single-sided pages (including all attachments, resumes, charts, etc.) presented in single-space and using a 12-point font size minimum, in either Microsoft Word or Adobe Portable Document Format (PDF), with 8-1/2 by 11 inch paper size, and 1 inch top, bottom, left and right margins. 6. All proprietary information should be marked as such. Statements should also include an indication of current certified small business status; this indication should be clearly marked on the first page of your capability statement (preferably placed under the eligible small business concern's name and address). Responses will be reviewed only by NIH personnel and will be held in a confidential manner. CLOSING STATEMENT: The capability statement should be submitted electronically (via email) to Dorothy Maxwell, Contract Specialist, at maxwelld@mail.nih.gov, on May 12, 2014, 8:00 A.M., EASTERN TIME and must reference synopsis number HHS-NIH-NHLBI-CSB-(HG)-SBSS-2014-113-DLM. All responses must be received by the specified due date and time in order to be considered. This Sources Sought Notice (SS) is for information and planning purposes only and shall not be construed as a solicitation or as an obligation on the part of the National Heart, Lung, and Blood Institute (NHLBI). The NHLBI does not intend to award a contract on the basis of responses nor otherwise pay for the preparation of any information submitted. As a result of this notice, the NHLBI may issue a Request for Quote (RFQ). THERE IS NO SOLICITATION AVAILABLE AT THIS TIME. However, should such a requirement materialize, no basis for claims against NHLBI shall arise as a result of a response to this notice or the NHLBI's use of such information as either part of our evaluation process or in developing specifications for any subsequent requirement. "Disclaimer and Important Notes. This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)."
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/HHS-NIH-NHLBI-CSB-(HG)-SBSS-2014-113-DLM/listing.html)
- Place of Performance
- Address: NIH/5635 Fishers Lane, Rockville, Maryland, United States
- Record
- SN03357601-W 20140507/140505234847-2baa2f598899e6bfe3132c4094dcf2c0 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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