SOLICITATION NOTICE
A -- Framingham Heart Study
- Notice Date
- 4/15/2014
- Notice Type
- Presolicitation
- NAICS
- 541712
— Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NHLBI-HV-15-01
- Point of Contact
- Erin Dwyer, Phone: 3014350346, Elizabeth Zoller, Phone: 301-435-0374
- E-Mail Address
-
Erin.dwyer@nih.gov, zollere@mail.nih.gov
(Erin.dwyer@nih.gov, zollere@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- The Division of Cardiovascular Sciences of the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), is seeking a center for a five year renewal of the program entitled "Framingham Heart Study". The purpose of this announcement is to provide a Presolicitation Notice for the release of Solicitation NHLBI-HV-15-01. THIS IS A SYNOPSIS. THIS IS NOT A SOLICITATION. The Framingham Heart Study is a long-term multigenerational study that aims to identify genetic and environmental factors influencing the development of cardiovascular and other diseases. Examination of over 5,000 residents of Framingham, Massachusetts was initiated in 1948 (this cohort is hereafter referred to as the "Original" participants). About two decades later, the offspring of the Original participants were recruited into the study (hereafter referred to as "Offspring" and including the new offspring spouses). This was followed about three decades later by the third generation of original Framingham participants (hereafter referred to as "Generation 3"). In 2009, two minority cohorts (Omni Groups 1 and 2), which had been initiated by study investigators and funded by NIH grants, were integrated into the Framingham contract. The designs and timing of the Omni Groups 1 and 2 examinations match those of the Offspring and Generation 3 cohorts, respectively. Except for the Original cohort, each cohort has recently undergone repeat examinations every 6 years. The overall objective of this renewal is to continue the Framingham Heart Study as a scientific resource for the research community to expand knowledge about the determinants of health and diseases in heart, lung, blood, and sleep disorders. In particular, this contract will support: 1) follow-up of study participants (anticipated total sample size ~ 8,120) for clinical events, and 2) the core study operations, including maintaining the study's rich repository of data and biospecimens for use in ancillary studies (i.e., studies that are funded outside of the contract with NHLBI). A limited clinical examination of the Generation 3 and Omni Group 2 cohorts is planned in the statement of work as a separate component in this contract. The NHLBI will determine later whether to award this specific component. For instance, it may decide not to fund a clinical examination if no ancillary study grant application is successfully funded by an NIH Institute or Center. If the NHLBI does decide to award the exam, the Contractor shall be expected to work closely with ancillary study investigators and to coordinate exam components from multiple funding sources and the ancillary-study principal investigators. The important overall technical requirements associated with the Framingham Heart Study include the following: • Provide appropriate senior personnel with expertise in epidemiology, statistics, and longitudinal studies management. • Conduct events follow-up for morbidity and mortality of Original, Offspring, Generation 3, Omni Group 1, and Omni Group 2 participants (the anticipated total number of participants expected to be alive in 2015 and thus followed up is ~ 8,120). • Maintain the study's biospecimen repository. • Establish and maintain study databases, including updating the databases with data from newly ascertained events and ancillary studies both for internal use and for posting on dbGaP (http://www.ncbi.nlm.nih.gov/gap) and BioLINCC (https://biolincc.nhlbi.nih.gov). • Conduct a re-examination of the Generation 3 and Omni Group 2 cohorts. [Note: This is a separate Task Area for which NHLBI will determine later whether to award] • Coordinate and participate collaboratively in study committees to provide a transparent committee process, open access to study materials, clear policies for access to data and materials, and an approval process for projects that is fair and balanced. • Establish and direct appropriate quality assurance programs. • Perform administrative duties to support productive collaboration among both study investigators and collaborating investigators. • Prepare and submit a request for Office of Management and Budget clearance. • Arrange for and manage annual meetings of an NHLBI-appointed Observational Studies Monitoring Board as directed by the NHLBI Project Office. • Participate actively in statistical analyses for quality assurance and, as funding allows, for scientific publications and presentations. • Provide two-year epidemiology training to two contract-supported research fellows. • If required by NHLBI, perform activities related to study closeout. • Work cooperatively with all study investigators and staff, including NHLBI intramural Framingham investigators, the NHLBI Project Office, and any subcontractors, in all relevant aspects of the study. This is not a Request for Proposal (RFP) and the Government is not committed to award a contract pursuant to this announcement. This advertisement does not commit the Government to award a contract. The RFP will be available on the FedBizOpps Web page at http://www.fedbizopps.gov. Prospective offerors are responsible for downloading the RFP and all attachments. The offeror is responsible for monitoring the FedBizOpps Web page for the release of the solicitation and any amendments. The RFP will be available from the FedBizOpps on or about May 5, 2014.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/NHLBI-HV-15-01/listing.html)
- Place of Performance
- Address: Framingham, Massachusetts, United States
- Record
- SN03339240-W 20140417/140415235045-99fc0b69ae5ae090cfe3ee0f92be62d1 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |