SOURCES SOUGHT
66 -- PacBio RS II System
- Notice Date
- 3/19/2014
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- HHS-NIH-NHLBI-CSB-(HG)-SBSS-2014-095-DLM
- Archive Date
- 4/12/2014
- Point of Contact
- Dorothy Maxwell, Phone: 301-435-0352
- E-Mail Address
-
maxwelld@mail.nih.gov
(maxwelld@mail.nih.gov)
- Small Business Set-Aside
- Total Small Business
- Description
- This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice." PacBio RSII System, (Specified Brand Name: Pacific Biosciences) NO REFURBISHED OR USED SYSTEMS ARE ACCEPTABLE. A. BACKGROUND: The National Institutes of Health (NIH) mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. The National Human Genome Research Institute (NHGRI) led the National Institutes of Health's (NIH) contribution to the International Human Genome Project, which had as its primary goal the sequencing of the human genome. This project was successfully completed in April 2003. Now, the NHGRI's mission has expanded to encompass a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. NHGRI supports the development of resources and technology that will accelerate genome research and its application to human health. A critical part of the NHGRI mission continues to be the study of the ethical, legal and social implications (ELSI) of genome research. NHGRI also supports the training of investigators and the dissemination of genome information to the public and to health professionals. The National Human Genome Research Institute NHGRI), NIH Intramural Sequencing Center (NISC) is a high-throughput sequencing center supporting all institutes within the NIH. NISC has served the NIH community for over 15 years as a source for high-quality large-scale sequencing and analysis. As next generation sequencing applications expand, so does the demand for NISC services. NISC currently has one (1) HiSeq 25000, three (3) MiSeq Systems, and four (4) HiSeq 2000 Systems which are proven platforms for genetic analysis and functional genomics. However these instruments provide a maximum read length of 300 bases. Complex genomes cannot be de novo assembled into one piece with reads of this length. Typically even small microbial genomes are in 50-300 pieces even with 100x coverage. Also there are ALWAYS missing pieces to the genome. The PacBio RS II produces read lengths in excess of 10,000 bases. The sample preparation for sequencing does not require amplification, so there is no risk of artifact introduction. The PacBio RS II sequencing technology has the added advantage of identifying modified bases which among other things can indicate the activity of genes in the tissue from which the DNA was derived. The accompanying computer provides real-time processing to reduce the data to a manageable size for downstream analysis. B. PURPOSE AND OBJECTIVES: The PacBio RS II allows researchers to obtain extremely long sequence reads that open up many new possibilities in the field of genomics. The simple library method involves no amplification and can be performed in 1day in most cases. These features allow NISC to support microbial genome, virus genome, RNA isoform, methylation studies and more that have never been possible before. C. PROCUREMENT: 1. PacBio RSII System including instrument, Blade Center, PacBio Software Suite and Installation Kit with 12-Month Standard Service Contract, Part Number: 100-210-100, Quantity: One (1) Each. 2. Trade-In Genome Sequencer FLX 454. 3. UPS, 200/208-240 VAC, 1 Phase 60 HZ, -PB Instrument Grade UPS, Part Number: 100-217-000, Quantity: One (1) Each. 4. On-Site System Training (3 Days), Part Number: 100-125-100, Quantity: One (1) Each. D. SCOPE OF WORK: Contractor Requirements : • The Contractor shall provide uncrating and set up of the instrument. • The Contractor shall validate that the instrument is operating fully and will provide full training for library construction, instrument operation, and bioinformatics post-run processing and assembly. Inspection and Acceptance Requirements : • The Contractor shall deliver instrument, computer and accessories in good working condition. The Government will verify satisfactory performance of the instrument. E. ANTICIPATED PERIOD OF PERFORMANCE: Delivery within 4-6 weeks upon award F. CAPABILITY STATEMENT/INFORMATION SOUGHT: Interested parties are expected to review this notice to familiarize itself with the requirements of this project. Failure to do so will be at your firm's own risk. The following information shall be included in the capability statement: 1. A general overview of the respondents' opinions about the difficulty and /or feasibility of the potential requirement, and any information regarding innovative ideas or concepts. 2. Information in sufficient details of the respondents' (a) staff expertise, including their availability, experience, and formal and other training; (b) current in-house capability and capacity to perform the work; (c) prior completed projects of similar nature; (d) corporate experience and management capability; and (e) examples of prior completed Government contracts, references, and other related information. 3. The respondents' DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HUBZone, etc) pursuant to the North American Industry Classification System (NAICS) code: 334516 Analytical Laboratory Instrument Manufacturing, small business size standard is 500 Employees. 4. Any other information that may be helpful in developing or finalizing the requirements of the potential acquisition. 5. The capability statement shall not exceed 10 single-sided pages (including all attachments, resumes, charts, etc.) presented in single-space and using a 12-point font size minimum, in either Microsoft Word or Adobe Portable Document Format (PDF), with 8-1/2 by 11 inch paper size, and 1 inch top, bottom, left and right margins. 6. All proprietary information should be marked as such. Statements should also include an indication of current certified small business status; this indication should be clearly marked on the first page of your capability statement (preferably placed under the eligible small business concern's name and address). Responses will be reviewed only by NIH personnel and will be held in a confidential manner. G. CLOSING STATEMENT: The capability statement should be submitted electronically (via email) to Dorothy Maxwell, Contract Specialist, at maxwelld@mail.nih.gov, on March 28, 2014, 7:30 AM, EASTERN TIME and must reference synopsis number HHS-NIH-NHLBI-CSB-(HG)-SBSS-2014-095-DLM. All responses must be received by the specified due date and time in order to be considered. This Sources Sought Notice (SS) is for information and planning purposes only and shall not be construed as a solicitation or as an obligation on the part of the National Heart, Lung, and Blood Institute (NHLBI). The NHLBI does not intend to award a contract on the basis of responses nor otherwise pay for the preparation of any information submitted. As a result of this notice, the NHLBI may issue a Request for Quote (RFQ). THERE IS NO SOLICITATION AVAILABLE AT THIS TIME. However, should such a requirement materialize, no basis for claims against NHLBI shall arise as a result of a response to this notice or the NHLBI's use of such information as either part of our evaluation process or in developing specifications for any subsequent requirement. "Disclaimer and Important Notes. This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)."
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/HHS-NIH-NHLBI-CSB-(HG)-SBSS-2014-095-DLM/listing.html)
- Place of Performance
- Address: NIH/Building 50, Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN03314583-W 20140321/140319234842-cb041dc39da5293d28c2bbd4407024d1 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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