SOLICITATION NOTICE
66 -- 400 MHz Nuclear Magnetic Resonance (NMR) Instrument for WRAIR.
- Notice Date
- 2/12/2014
- Notice Type
- Combined Synopsis/Solicitation
- Contracting Office
- US Army Medical Research Acquisition Activity, ATTN: MCMR-AAA, 820 Chandler Street, Frederick, MD 21702-5014
- ZIP Code
- 21702-5014
- Solicitation Number
- W81XWH-14-T-0101-0001
- Response Due
- 3/14/2014
- Archive Date
- 4/13/2014
- Point of Contact
- Sharew Hailu, 301-619-9201
- E-Mail Address
-
US Army Medical Research Acquisition Activity
(sharew.hailu.civ@mail.mil)
- Small Business Set-Aside
- N/A
- Description
- This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. This effort is in support of the WRAIR Experimental Therapeutics Branch (ET) infectious disease programs. The synthetic chemistry labs require the delivery, installation, and training on one 400 MHz Nuclear Magnetic Resonance (NMR) instrument. The NMR instrument is critical to characterize and determine purity of potential small-molecule antimalarial agents generated from the synthetic efforts of antimalarial lead optimization projects within the Department of Drug Development. Background: The supplies covered in this document include one 400 MHz Nuclear Magnetic Resonance instrument. The system is offered as a package to include the necessary hardware, software, installation, and training to enable proper use and maintenance of the equipment. Failure to purchase/install this instrument will dramatically impact ET's mission as older equipment nears the end of life-cycle management. The objectives of these programs are: (1)Provide a scientific instrument that can elucidate the structures of small organic molecules generated from synthetic efforts for drug discovery. (2)Provide a scientific instrument that can unambiguously identify and analyze the purity of the molecules generated from synthetic efforts for drug discovery. Scope of Work -The contractor shall provide the delivery, installation, and training on a 400 MHz Nuclear Magnetic Resonance instrument. -The contractor will ensure that the instrument is tested and functional upon installation. -The contractor will make sure that no parts of the equipment are missing, undelivered or damaged and that the instrument as a whole is delivered, complete and functional. -The contractor will ensure that all appropriate users are trained on the 400 MHz Nuclear Magnetic Resonance instrument. -The contractor will ensure the maintenance section is trained on general and preventive maintenance on the 400 MHz Nuclear Magnetic Resonance instrument. -Contractor will ensure that all tasks related to the scope of work are completed and confirmed by the WRAIR Medical Maintenance and Division POC/COR. The Contractor/vendor will meet the minimum essential characteristics specified below for the 400 MHz Nuclear Magnetic Resonance instrument. -Contractor will safely shut down and remove existing 300 MHz Nuclear Magnetic Resonance instrument to include Superconducting Magnet System, Consol, and expandable items associated with the instrument. -Contractor will be prepared to safely shut down and remove existing 600 MHz Nuclear Magnetic Resonance instrument to include Superconducting Magnet System, Consol, and expandable items associated with the instrument. -Contractor will notify COR of all necessary requirements and safety precautions if prior shut down protocol is necessary for the removal of the existing 300 and/or 600 MHz Nuclear Magnetic Resonance instruments. -Contractor will notify COR of all dates and times need for transfer of the existing and new Nuclear Magnetic Resonance instruments for allocation of loading dock times. Minimum Essential Characteristics: 400 MHz Nuclear Magnetic Resonance instrument to include: Compact ASCEND Superconducting Magnet System with 5.4 cm bore, (operation field at 11.744 Tesla) including helium and nitrogen level sensors and magnet stand. Advanced magnet design for very significant reduction of the stray field and incorporates active reridgeration with air-cooled compressor, which which makes the magnet liquid nitrogen free. It will require vendor's annual Car-free maintenance program. Incorporates advanced External Disturbance Suppression (EDS) for dramatic reduction of magnetic field perturbations from sources such as subways and electric trains. Smart Magnet System shim and 2G DigiLock control, including Digital Frequency Generation, Digital Quadrature Receiver, computer-controlled lock regulation system and ultra-stable, low current noise Shim Control Boards (SCBs). Orthogonal Shim System with 20 low current and low heat dissipation gradient shims. Sample Transport upper shim stack. Enables high flow rates for VT gas and includes integral sensors for communication with the Smart Magnet System. A Helium transfer line. A stainless steel RF cabinet with HD Nano-Bay, 19 quote mark rack mounted cabinet with rf shielding and full front access to all sub-assemblies and cabling. Expandable to three channels, as needed. CryoProbe ready. Enhanced 2G Digital Quadrature Detection Receiver (RXAD/2) with integrated high performance ADCs. Provide high dynamic range, high digital resolution and large bandwith digital filtering. BLA2BB dual broadband amplifier, including two broadband amplifiers providing up to 150 Watts X-frequency (6-163 MHz) and 50 Watts 19F or 1H frequency for both observe and homo/heteronuclear decoupling in both CW and high power pulse operations; all operations under computer control. Timing Controller provides exact timing and full flexibility in data acquisition with 12.5 nsec timing resolution. Enhanced RF generation including Signal Generation Unit (SGU/3) for 2 channels, for generation of phase, amplitude, and frequency using Direct Digital Synthesis (DDS) covering a frequency range from 6 to 600MHz. Provides less than 0.01o phase settability and less than 0.005 Hz frequency resolution. Digital up conversion at 960MHz. Includes high performance wave form memory for programming of experimental sequences including ultra-fast pulse programming, pulse shaping and composite pulse decoupling executable synchronously or asynchronously. Gradient Controller for simultaneous control of up to three magnetic field gradients with real time generation of gradient shapes. Digital Receiver Unit (DRU) with integrated high performance digital filters and Digital Quadrature Detection (DQD) that virtually eliminates quad images and spikes and 60 Hz interference in experiments for large sweep widths. Integrated preamplifier, including: 1H preamplifier with 2D capability for lock and observe and BB preamplifier. Windows workstation with the following configuration Intel Dual Core 2.53GHz Processor 16 GB memory 24 inch Flat Panel monitor 1 TB Hard Drive 16X max DVD RW/CD-RW drive 2 X LAN 10/100/1000 ethernet adapters 104+ Keyboard Scrolling Mouse, mouse pad Microsoft Windows OS One year manufacturer's warranty on PC Acronis Disk Imaging Software Software package to include acquisition and processing of 1D, 2D, 3D and 4D NMR data, including PLOT, ICON NMR, NMR Guide and NMR-SIM. Includes media, on-line hypertext manual and single license. Multinuclear broadband Fluorine Observe (BBFO) probe (5 mm sample diameter) with digital tuning covering the range from 15N to 31P and 19F with 1H decoupling. GRASP II version, including actively shielded Z-gradient coil for use with GRASP II, GRASP II/A or GRASP III accessory. VT range -150 to +150 oC. Automatic Tuning and Matching (ATM) Accessory permits computer control of nucleus selection as well as tuning and matching from sample to sample for optimum automation.. GRASP II GRAdient SPectroscopy accessory for the NMR series. Includes single channel ultra-stable GAB/2 power supply with digital pre-emphasis adjustment and single channel gradient amplifier (10 Amp, 50 Gauss/cm). Requires a probe with built-in gradient coil. Deuterium gradient shimming including Deuterium amplifier. NMR will be located on the second floor and should contain a vibration reduction system, if necessary. Complete system installation, including magnet, by qualified personnel. Advanced Smart Variable Temperature control unit, with digital control module. Connects to thermocouple and heater incorporated into probes. All functions under full computer control. Temperature accuracy 0.2 C (with 1.0 C room temperature stability), but 0.01 C within the temperature range of +15 to +35 C. Maximum temperature 200 C. Low temperature accessory for Variable Temperature control unit, including 26 liter N2 Dewar, heat exchanger and insulated PUR transfer line, for operation down to -80 C. Complete set of system documentation. Deliverables/Schedule (POA&M) 1.1 The contractor will be required to produce and deliver the following: 1. Contractor will provide training material in the form of user manuals and power point slides of the training to the WRAIR POC/COR. 2. Contractor will deliver the 400 MHz NMR instrument, install and train the respective users in the division of Experimental Therapeutics to meet the minimum essential requirements listed in the scope of work. 3. Contractor will ensure the 400 MHz NMR instrument is working and properly shimmed upon installation completion. 4. Contractor will properly and safely shut down and remove 300 MHz NMR along with the NMR's components, prior to installation of new 400 MHz NMR. 5. Contractor will be prepared to properly and safely shut down and remove 600 MHz NMR along with the NMR's components. 6. Contractor will train Medical Maintenance on the preventative and essential overall system maintenance. 7. Contractor will coordinate with COR to ensure loading dock is free and has access to remove 300 MHz NMR and be replaced with 400 MHz NMR. 8. Contractor will coordinate any essential actions and/or information regarding the shut down of the existing NMR, Helium or Nitrogen removal or fill for existing NMR or incoming NMR, timeline of both 300 MHz NMR removal and 400 MHz NMR instillation, and any equipment necessary for the installation and removal of the NMR's. Contractor will need to define weight requirements for support of the NMR systems to ensure service elevators can handle the load. Contractor will need to define room size requirement, to include distance between consol and magnet, and necessary electrical requirement. 1.2 Place of Delivery All deliverables under this contract consisting of reports, data and other documents shall be delivered to the WRAIR technical point of contact in the Division of ET WRAIR lab 2E13, 503 Robert Grant Ave., Silver Spring, MD 20910. Place of Performance: The primary place of performance will be at the Walter Reed Army Institute of Research.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/USA/USAMRAA/DAMD17/W81XWH-14-T-0101-0001/listing.html)
- Place of Performance
- Address: US Army Medical Research Acquisition Activity ATTN: MCMR-AAA, 820 Chandler Street Frederick MD
- Zip Code: 21702-5014
- Zip Code: 21702-5014
- Record
- SN03287686-W 20140214/140212234710-603b96466f19a2a7ff842fb5386ffd72 (fbodaily.com)
- Source
-
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