SOLICITATION NOTICE
70 -- Integration of Ayrris Large Appliance and LIMS 24/7 - 508 Language - IT Security
- Notice Date
- 12/17/2013
- Notice Type
- Presolicitation
- NAICS
- 541511
— Custom Computer Programming Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NIH-HHS-NHLBI-CSB-(HG)-2014-039-DLM
- Archive Date
- 1/4/2014
- Point of Contact
- Dorothy Maxwell, Phone: 301-435-0352
- E-Mail Address
-
maxwelld@mail.nih.gov
(maxwelld@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- IT Security Provisions 508 Compliance Language INTRODUCTION : The National Institute of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) Office of Acquisition (OA) on behalf of the National Human Genome Research Institute, (NHGRI), intends to negotiate and award a purchase order on a noncompetitive sole source basis to Appistry Inc., 1141 South 7th Street, Suite 300, St. Louis, MO 63104 to procure the following: BRAND NAME : (APPISTRY, LARGE APPLIANCE (SOFTWARE) SEE ATTACHMENT A: IT SECURITY PROVISIONS AND ATTACHMENT B: 508 COMPLIANCE LANGUAGE. Procurement: 1. Ayrris Large Appliance (software only) Annual contract; 2. Twelve months managed hosting of Ayrris on up to 512 Nodes; 3. UDP Pipeline Development and Integration of Pipeline with RURO LIMS 24/7 with Conversion to BioWolf. BACKGROUND : The National Institutes of Health (NIH) is the nation's leading medical research agency and the primary Federal agency conducting and supporting medical discoveries that improve people's health and save lives. The National Human Genome Research Institute (NHGRI), National Institutes of Health Undiagnosed Disease Program (UDP) is a trans-National Institute of Health (NIH) initiative that focuses on the most puzzling medical cases referred to the NIH Clinical Center in Bethesda, MD. It was organized by the National Human Genome Research Institute (NHGRI), the NIH Office of Rare Diseases Research (ORDR) and the NIH Clinical Center. Many medical specialties from other NIH research centers and institutes contribute the expertise needed to conduct the program, including endocrinology, immunology, oncology, dermatology, dentistry, cardiology and genetics, among the dozens of participating senior attending physicians. A longstanding medical condition that eludes diagnosis by a referring physician can be considered undiagnosed and may be of interest to this clinical research program. identified new and rare diseases. Genomic DNA is isolated from all admitted Undiagnosed Diseases patients and family members. Depending on the phenotype of the patient, these DNA samples are sent for exome sequencing as the first step to obtain variant information that may determine the mechanism of the patients' disease. It is necessary for the Undiagnosed Diseases Laboratory to then perform extensive analyses on the large amount of exome sequencing and variant data that is generated in a timely manner to facilitate genetic studies when combined with SNP analysis. This information will then be used to perform research experiments to discern the genetic and molecular basis of the unique disease of the patient. Critical to accomplishing this goal is the use of the diploid alignment methodology developed in the NIH UDP. Objectives: The current use of alignment of NGS short reads to a monoploid canonical reference is successful for the majority of a random individual's genome that has adequate entropy given current sequence lengths and error rates. However, in the absence of other corroborating evidence, the NIH UDP needs a complete survey of the entire genome before committing the resources to validate candidate variant(s). To generate a more complete alignment, the diploid-alignment pipeline uses SNP chips, leveraged with imputation based on 1K genome haplotypes, to modify the canonical reference into two different parental references that are subsequently used to align short reads of an offspring. Time complexity is increased by 3.5X over standard monoploid alignment thereby requiring HPC resources and expertise to provide results in reasonable timeframes. Period of Performance : Twelve (12) months from the date of award. JUSTIFICATION: A. Scope of Work: NHGRI will establish a collaboration to develop the next generation sequence alignment and genotyping tools that will be available to the research community, including NIH. NHGRI will provide the Contractor the genetic data (SNP chip data and Illumina lane fines (sequence data) from up to sixty (60) patients from the Undiagnosed Diseases Program (UDP. The information is collected with patient consent obtained under Clinical Protocol Number: 76-HG-0238. No personally identifiable information or code to such personally identifiable information will be provided. The Contractor will integrate Ayrris into NIH CIT Biowulf which will allow all NIH UDP genomic data to remain within the NIH instead of being transferred to an outside data center, which would eliminate the time to transfer data to and from Bethesda and will enable other NIH Biowulf users to leverage the Ayrris computing environment when the Diploid-Alignment is not running. B. Project: The Contractor will use the data to implement and refine the processes developed by the NIH UDP for diploid alignment and subsequent genotyping and annotation of next generation sequence data derived from UDP patients. Information will be provided to the Contractor by secure mail, by encrypted ftp or on an encrypted hard drive. Specifically, the Imation Defender external USB hard drives that provide secure hardware encryption in a tamper-resistant metal closure and use hardware-based encryption of FIPS 140-2 Level 3 validated (Certification #1269) will be utilized; this meets federal regulatory requirements for encryption of sensitive, but unclassified data. The Contractor agrees to store the information in a suitably secure and confidential manner that restricts access by any individual not involved in the Research Project. Upon completion of the Research Project the Contract will forward the results and conclusions obtained during the Research Project to NIH/UDP and upon request, destroy or return to NIH/UDP all copies of the information that are in the Contractor's possession. This information may not be used in Human Subject Research. C. Other considerations : 1. Ability to use Appistry Inc. Large Appliance. 2. Compliance with HIPAA, Safe Harbor and CLIA Regulations. 3. Ability to integrate the system in partnership with RuRo Inc., LIMS 24/7 System. 4. Must show proof of HIPAA Compliant Encrypted Infrastructure for Storing and Analyzing Protected Health Information (PHI). 5. Ability to process more than 1000 exomes in accordance to UDP diploid alignment and genotyping pipeline within 6-months. REGULATORY AUTHORITY: This acquisition is conducted under the authority of 41 U.S.C. 253(c) as set forth in FAR Part 6.302-1, only one responsible source and no other supplies or services will satisfy agency requirements. ADDITIONAL INFORMATION : Industry Classification (NAICS) Code is 541511, Custom Programming Services, small business size standard is $25.5M.. The acquisition is being conducted under FAR Part 13, simplified acquisition procedures, therefore the requirements of FAR Part 6 B Competitive Requirements are not applicable (FAR Part 6.001). The resultant Contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 05-71 (November 25, 2013). This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by December 20, 2013 and must reference synopsis number HHS-NIH- NHLBI-CSB-(HG)-2014-039-DLM, may be submitted to the National, Heart, Lung and Blood Institute, Office of Acquisition, COAC Services Branch, 6701 Rockledge Drive, Suite 6149, Bethesda, Maryland 20892-7902, Attention: Dorothy Maxwell. Response may be submitted electronically to maxwelld@mail.nih.gov. Faxes will not be accepted. Responses will only be accepted if dated and signed by an authorized company representative. "All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency."
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/NIH-HHS-NHLBI-CSB-(HG)-2014-039-DLM/listing.html)
- Place of Performance
- Address: Vendor's Location and NIH Bethesda Maryland, United States
- Record
- SN03253632-W 20131219/131217235539-354fd762d4efa4b9813bf000e181019c (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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