SOURCES SOUGHT
70 -- Integration of Ayrris Large Appliance and LIMS 24/7 - IT Security - 508 Compliance
- Notice Date
- 12/4/2013
- Notice Type
- Sources Sought
- NAICS
- 541511
— Custom Computer Programming Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- HHS-NIH-NHLBI-CSB-(HG)-SBSS-2014-018-DLM
- Archive Date
- 12/25/2013
- Point of Contact
- Dorothy Maxwell, Phone: 301-435-0352
- E-Mail Address
-
maxwelld@mail.nih.gov
(maxwelld@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- 508 Accessibility Standards IT Security Provisions This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice." BRAND NAME: (APPISTRY, LARGE APPLIANCE (SOFTWARE) AND HOSTING OF 512 NODES) SEE ATTACHMENT A: IT SECURITY PROVISIONS AND ATTACHMENT B: 508 COMPLIANCE LANGUAGE. A. Background: The National Institute of Health (NIH) is the nation's leading medical research agency and the primary Federal agency conducting, supporting and making medical discoveries that improve people's health and save lives. The National Institutes of Health Undiagnosed Disease Program (UDP) is a trans-National Institute of Health (NIH) initiative that focuses on the most puzzling medical cases referred to the NIH Clinical Center in Bethesda, Md. It was organized by the National Human Genome Research Institute (NHGRI), the NIH Office of Rare Diseases Research (ORDR) and the NIH Clinical Center. Many medical specialties from other NIH research centers and institutes contribute the expertise needed to conduct the program, including endocrinology, immunology, oncology, dermatology, dentistry, cardiology and genetics, among the dozens of participating senior attending physicians. A longstanding medical condition that eludes diagnosis by a referring physician can be considered undiagnosed and may be of interest to this clinical research program. Genomic DNA is isolated from all admitted Undiagnosed Diseases patients and family members. Depending on the phenotype of the patient, these DNA samples are sent for exome sequencing as the first step to obtain variant information that may determine the mechanism of the patients' disease. It is necessary for the Undiagnosed Diseases Laboratory to then perform extensive analyses on the large amount of exome sequencing and variant data that is generated in a timely manner to facilitate genetic studies when combined with SNP analysis. This information will then be used to perform research experiments to discern the genetic and molecular basis of the unique disease of the patient. Critical to accomplishing this goal is the use of the diploid alignment methodology developed in the NIH UDP. B. Purpose and Objectives: The current use of alignment of NGS short reads to a monoploid canonical reference is successful for the majority of a random individual's genome that has adequate entropy given current sequence lengths and error rates. However, in the absence of other corroborating evidence, the NIH UDP needs a complete survey of the entire genome before committing the resources to validate candidate variant(s). To generate a more complete alignment, the diploid-alignment pipeline uses SNP chips, leveraged with imputation based on 1K genome haplotypes, to modify the canonical reference into two different parental references that are subsequently used to align short reads of an offspring. Time complexity is increased by 3.5X over standard monoploid alignment thereby requiring HPC resources and expertise to provide results in reasonable timeframes. C. Scope of Work: NHGRI will establish a collaboration to develop the next generation sequence alignment and genotyping tools that will be available to the research community, including NIH. NHGRI will provide the Contractor the genetic data (SNP chip data and Illumina lane fines (sequence data) from up to sixty (60) patients from the Undiagnosed Diseases Program (UDP. The information is collected with patient consent obtained under Clinical Protocol Number: 76-HG-0238. No personally identifiable information or code to such personally identifiable information will be provided. The Contractor will integrate Ayrris into NIH CIT Biowulf which will allow all NIH UDP genomic data to remain within the NIH instead of being transferred to an outside data center, which would eliminate the time to transfer data to and from Bethesda and will enable other NIH Biowulf users to leverage the Ayrris computing environment when the Diploid-Alignment is not running. D. Project: The Contractor will use the data to implement and refine the processes developed by the NIH UDP for diploid alignment and subsequent genotyping and annotation of next generation sequence data derived from UDP patients. Information will be provided to the Contractor by secure mail, by encrypted ftp or on an encrypted hard drive. Specifically, the Imation Defender external USB hard drives that provide secure hardware encryption in a tamper-resistant metal closure and use hardware-based encryption of FIPS 140-2 Level 3 validated (Certification #1269) will be utilized; this meets federal regulatory requirements for encryption of sensitive, but unclassified data. The Contractor agrees to store the information in a suitably secure and confidential manner that restricts access by any individual not involved in the Research Project. Upon completion of the Research Project the Contract will forward the results and conclusions obtained during the Research Project to NIH/UDP and upon request, destroy or return to NIH/UDP all copies of the information that are in the Contractor's possession. This information may not be used in Human Subject Research. E. Other considerations: 1. Ability to use Appistry Inc. Large Appliance. 2. Compliance with HIPAA, Safe Harbor and CLIA Regulations. 3. Ability to integrate the system in partnership with RuRo Inc., LIMS 24/7 System. 4. Must show proof of HIPAA Compliant Encrypted Infrastructure for Storing and Analyzing Protected Health Information (PHI). 5. Ability to process more than 1000 exomes in accordance to UDP diploid alignment and genotyping pipeline within 6-months. F. Anticipated Period of Performance: Twelve (12) months from the date of award. G. Capability Statement /Information: Interested parties are expected to review this notice to familiarize itself with the requirements of this project. Failure to do so will be at your firm's own risk. The following information shall be included in the capability statement: 1. A general overview of the respondents' opinions about the difficulty and /or feasibility of the potential requirement, and any information regarding innovative ideas or concepts. 2. Information in sufficient details of the respondents' (a) staff expertise, including their availability, experience, and formal and other training; (b) current in-house capability and capacity to perform the work; (c) prior completed projects of similar nature; (d) corporate experience and management capability; and (e) examples of prior completed Government contracts, references, and other related information. 3. The respondents' DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HUBZone, etc) pursuant to the North American Industry Classification System (NAICS) code: 541511 Custom Programming Services, small business size standard is $25.5M. 4. Any other information that may be helpful in developing or finalizing the requirements of the potential acquisition. 5. The capability statement shall not exceed 20 single-sided pages (including all attachments, resumes, charts, etc.) presented in single-space and using a 12-point font size minimum, in either Microsoft Word or Adobe Portable Document Format (PDF), with 8-1/2 by 11 inch paper size, and 1 inch top, bottom, left and right margins. 6. All proprietary information should be marked as such. Statements should also include an indication of current certified small business status; this indication should be clearly marked on the first page of your capability statement (preferably placed under the eligible small business concern's name and address). Responses will be reviewed only by NIH personnel and will be held in a confidential manner. H. Closing Statement: The capability statement should be submitted electronically (via email) to Dorothy Maxwell, Contract Specialist, at maxwelld@mail.nih.gov, Sources Sought Soliciation Number: HHS-NIH-NHLBI-CSB-(HG)-SBSS-2014-018-DLM on December 10, 2013, 7:30 AM, EST. All responses must be received by the specified due date and time in order to be considered. This Sources Sought Notice (SS) is for information and planning purposes only and shall not be construed as a solicitation or as an obligation on the part of the National Heart, Lung, and Blood Institute (NHLBI). The NHLBI does not intend to award a contract on the basis of responses nor otherwise pay for the preparation of any information submitted. As a result of this notice, the NHLBI may issue a Request for Quote (RFQ). THERE IS NO SOLICITATION AVAILABLE AT THIS TIME. However, should such a requirement materialize, no basis for claims against NHLBI shall arise as a result of a response to this notice or the NHLBI's use of such information as either part of our evaluation process or in developing specifications for any subsequent requirement. "Disclaimer and Important Notes. This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)."
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/HHS-NIH-NHLBI-CSB-(HG)-SBSS-2014-018-DLM/listing.html)
- Place of Performance
- Address: NIH and Contractor's Location, United States
- Record
- SN03245543-W 20131206/131204234441-8968d2bb5bb665bdea2a1b2945d006c0 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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